Uqcrb MGI Mouse Gene Detail - MGI:1914780 - ubiquinol-cytochrome c reductase binding protein

Symbol

Uqcrb
Name

ubiquinol-cytochrome c reductase binding protein
Synonyms

2210415M14Rik, MGC:35665, QP-C

Feature Type

protein coding gene
IDs

MGI:1914780
NCBI Gene: 67530
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr13:67048681-67053442 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 34.54 cM, cytoband B3
Mapping Data

1 experiment

SNPs within 2kb

153 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914780	protein coding gene	Chr13:67048640-67053442 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020691	protein coding gene	Chr13:67005357-67010117 (-)
A/J	MGP_AJ_G0020645	protein coding gene	Chr13:64559589-64564364 (-)
AKR/J	MGP_AKRJ_G0020622	protein coding gene	Chr13:66692782-66697542 (-)
BALB/cJ	MGP_BALBcJ_G0020643	protein coding gene	Chr13:65046009-65051945 (-)
C3H/HeJ	MGP_C3HHeJ_G0020438	protein coding gene	Chr13:66321638-66326657 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021079	protein coding gene	Chr13:69348553-69353319 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018653	protein coding gene	Chr13:62239032-62244080 (-)
CAST/EiJ	MGP_CASTEiJ_G0019955	protein coding gene	Chr13:65522721-65529066 (-)
CBA/J	MGP_CBAJ_G0020398	protein coding gene	Chr13:71792412-71798327 (-)
DBA/2J	MGP_DBA2J_G0020523	protein coding gene	Chr13:64446744-64451516 (-)
FVB/NJ	MGP_FVBNJ_G0020502	protein coding gene	Chr13:63479235-63484024 (-)
LP/J	MGP_LPJ_G0020597	protein coding gene	Chr13:67245675-67250462 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020531	protein coding gene	Chr13:70664898-70673048 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021121	protein coding gene	Chr13:65973514-65979037 (-)
PWK/PhJ	MGP_PWKPhJ_G0019709	protein coding gene	Chr13:63439534-63444402 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019534	protein coding gene	Chr13:63004591-63009303 (-)
WSB/EiJ	MGP_WSBEiJ_G0020015	protein coding gene	Chr13:66452483-66457254 (-)

Human Ortholog

UQCRB, ubiquinol-cytochrome c reductase binding protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UQCRB, ubiquinol-cytochrome c reductase binding protein
Synonyms

MC3DN3, QCR7, QP-C, QPC, UQBC, UQBP, UQCR6, UQPC
Links

HGNC:12582

NCBI Gene ID: 7381

neXtProt AC: NX_P14927

UniProt: P14927
Chr Location

8q22.1; chr8:96222947-96235546 (-) GRCh38

MGI Vertebrate Homology

Uqcrb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UQCRB
Protein SuperFamily

Bc1_14K
Gene Tree

Uqcrb

Diseases

2 with human UQCRB associations

				Human Disease	Mouse Models
				inherited metabolic disorder IDs inherited metabolic disorder DOID:655 MESH:D008661 NCI:C34816 UMLS_CUI:C0025521
				mitochondrial complex III deficiency nuclear type 3 IDs mitochondrial complex III deficiency nuclear type 3 DOID:0080112 OMIM:615158

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

6
Targeted

4
Genomic Mutations

1 involving Uqcrb
Incidental Mutations

APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

885
Tissues

106
cDNA Data

163
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN uqcrb

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All Sequences

40
RefSeq

2
UniProt

2
CCDS

CCDS26610.1

Ensembl

ENSMUSG00000021520 (Evidence)
NCBI Gene

67530

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021520	Ensembl Gene Model \| MGI Sequence Detail	4762	C57BL/6J	± kb
transcript	ENSMUST00000021993	Ensembl \| MGI Sequence Detail	535	Not Applicable
polypeptide	ENSMUSP00000021993	Ensembl \| MGI Sequence Detail	111	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017123 cytochrome b-c1 complex subunit 7

(term hierarchy)
PDB

7O37, 7O3C, 7O3E, 7O3H, 8PW5, 8PW6, 8PW7
InterPro Domains

IPR003197 Cytochrome b-c1 complex subunit 7

IPR036544 Cytochrome b-c1 complex subunit 7 superfamily
GlyGen

Q9D855 1 site, 1 O-linked glycan (1 site)

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All nucleic 163

cDNA 163

Microarray probesets 5

Summaries

All 51

Developmental Gene Expression 5

Gene Ontology 10

Phenotypes 15
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:353791 Xu L, et al., Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells. Cell Stem Cell. 2024 Aug 16;

TSS for Uqcrb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123084	Chr13:67053386-67053434 (-)	32 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24