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Ppfibp1 Gene Detail
Summary
  • Symbol
    Ppfibp1
  • Name
    PTPRF interacting protein, binding protein 1 (liprin beta 1)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914783
    NCBI Gene: 67533
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:146789985-146933523 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 77.70 cM, cytoband G3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1851 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914783
 protein coding gene Chr6:146788107-146933523 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031493
 protein coding gene Chr6:151926113-152069805 (+)
A/J MGP_AJ_G0031468
 protein coding gene Chr6:145898800-146037363 (+)
AKR/J MGP_AKRJ_G0031396
 protein coding gene Chr6:150237552-150382200 (+)
BALB/cJ MGP_BALBcJ_G0031476
 protein coding gene Chr6:145657439-145797246 (+)
C3H/HeJ MGP_C3HHeJ_G0031197
 protein coding gene Chr6:150287156-150425719 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031937
 protein coding gene Chr6:155966459-156112822 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029061
 protein coding gene Chr6:144638584-144775369 (+)
CAST/EiJ MGP_CASTEiJ_G0030566
 protein coding gene Chr6:149925881-150069926 (+)
CBA/J MGP_CBAJ_G0031157
 protein coding gene Chr6:161928599-162076822 (+)
DBA/2J MGP_DBA2J_G0031313
 protein coding gene Chr6:144676508-144818793 (+)
FVB/NJ MGP_FVBNJ_G0031265
 protein coding gene Chr6:143420074-143557966 (+)
LP/J MGP_LPJ_G0031399
 protein coding gene Chr6:152006993-152149173 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031305
 protein coding gene Chr6:165648427-165796423 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031970
 protein coding gene Chr6:150061251-150201303 (+)
PWK/PhJ MGP_PWKPhJ_G0030292
 protein coding gene Chr6:143200695-143341107 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030116
 protein coding gene Chr6:148213495-148355545 (+)
WSB/EiJ MGP_WSBEiJ_G0030659
 protein coding gene Chr6:150679154-150823962 (+)



Homology
more
  • Human Ortholog
    PPFIBP1, PPFIA binding protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPFIBP1, PPFIA binding protein 1
  • Synonyms
    hSGT2, hSgt2p, L2, NEDSMBA, SGT2
  • Links
    NCBI Gene ID: 8496
    neXtProt AC: NX_Q86W92
    UniProt: Q86W92

  • Chr Location
    12p11.23-p11.22; chr12:27523431-27695564 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    36
  • cDNA Data
    135
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000016487 Ensembl Gene Model | MGI Sequence Detail 143539 C57BL/6J ±  kb
transcript ENSMUST00000111623 Ensembl | MGI Sequence Detail 4782 Not Applicable  
polypeptide ENSMUSP00000107250 Ensembl | MGI Sequence Detail 980 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 139
    Genomic 2
    cDNA 136
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2141668, MGI:2141674
References
more
  • Summaries
    All 40
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:241102 Leone DP, et al., Compensatory Actions of Ldb Adaptor Proteins During Corticospinal Motor Neuron Differentiation. Cereb Cortex. 2017 Feb 01;27(2):1686-1699
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory