Macroh2a3 Pseudogene Detail

Summary

• Symbol
  Macroh2a3
• Name
  macroH2A.3 histone
• Synonyms
  4933432H23Rik, H2afy3

• Feature Type
  pseudogene
• IDs
  MGI:1914802
  NCBI Gene: 67552
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr15:62090070-62091181 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 26.42 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  143 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914802	pseudogene	Chr15:62089390-62091300 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0011191	pseudogene	Chr15:61578110-61579221 (-)
A/J	MGP_AJ_G0011181	pseudogene	Chr15:59162548-59163659 (-)
AKR/J	MGP_AKRJ_G0011141	pseudogene	Chr15:60814602-60815713 (-)
BALB/cJ	MGP_BALBcJ_G0011148	pseudogene	Chr15:59357732-59358843 (-)
C3H/HeJ	MGP_C3HHeJ_G0011048	pseudogene	Chr15:60946969-60948080 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0011446	pseudogene	Chr15:63898093-63899204 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0010028	pseudogene	Chr15:56239323-56240441 (-)
CAST/EiJ	MGP_CASTEiJ_G0010873	pseudogene	Chr15:61600633-61603691 (-)
CBA/J	MGP_CBAJ_G0011029	pseudogene	Chr15:66150808-66151919 (-)
DBA/2J	MGP_DBA2J_G0011076	pseudogene	Chr15:59035398-59036509 (-)
FVB/NJ	MGP_FVBNJ_G0011076	pseudogene	Chr15:58082915-58084501 (-)
LP/J	MGP_LPJ_G0011167	pseudogene	Chr15:61459561-61460672 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0011070	pseudogene	Chr15:71129654-71130765 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0011421	pseudogene	Chr15:61207267-61208378 (-)
PWK/PhJ	MGP_PWKPhJ_G0010745	pseudogene	Chr15:59098673-59100439 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0010565	pseudogene	Chr15:60985773-60986893 (-)
WSB/EiJ	MGP_WSBEiJ_G0010918	pseudogene	Chr15:61232861-61233972 (-)

Homology

• Protein SuperFamily
  Core_histone_macro-H2A
• Gene Tree
  Macroh2a3
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  25 phenotype references
  

• All Mutations and Alleles
  7
• Chemically induced (other)
  3
• Gene trapped
  1
• Radiation induced
  2
• Transposon induced
  1
• Genomic Mutations
  6 involving Macroh2a3
• Find Mice (IMSR)
  0 strains or lines available

Expression

• Assay Results
  730
• Tissues
  15
• cDNA Data
  4
• Literature Summary
  1

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  26
• RefSeq
  1
• UniProt
  2

• Ensembl
  ENSMUSG00000101167 (Evidence)
• NCBI Gene
  67552

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000101167	Ensembl Gene Model | MGI Sequence Detail	1112	C57BL/6J
transcript	ENSMUST00000151919	Ensembl | MGI Sequence Detail	1112	Not Applicable
polypeptide	Q9D3V6	UniProt | EBI | MGI Sequence Detail	382	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• InterPro Domains
  IPR021171 Core histone macro-H2A
  IPR009072 Histone-fold
  IPR002119 Histone H2A
  IPR032454 Histone H2A, C-terminal domain
  IPR007125 Histone H2A/H2B/H3
  IPR002589 Macro domain
  IPR043472 Macro domain-like

Molecular
Reagents

• All nucleic 8

  cDNA 8

  
  

  Microarray probesets 1

Other
Accession IDs

MGI:6377089

References

• Summaries
  All 41

  Developmental Gene Expression 1

  Diseases 1

  Phenotypes 25
• Earliest
  J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
• Latest
  J:345376 Filipescu D, et al., MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping. Nat Cell Biol. 2023 Sep;25(9):1332-1345

TSS for Macroh2a3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134489	Chr15:62091295-62091301 (-)	-117 bp