Pigm MGI Mouse Gene Detail - MGI:1914806 - phosphatidylinositol glycan anchor biosynthesis, class M

Symbol

Pigm
Name

phosphatidylinositol glycan anchor biosynthesis, class M
Synonyms

4933437L05Rik, C920011G20Rik

Feature Type

protein coding gene
IDs

MGI:1914806
NCBI Gene: 67556
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr1:172204113-172211666 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 79.73 cM
Mapping Data

3 experiments

SNPs within 2kb

260 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914806	protein coding gene	Chr1:172204098-172211666 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016787	protein coding gene	Chr1:178238757-178246291 (+)
A/J	MGP_AJ_G0016766	protein coding gene	Chr1:170944148-170951705 (+)
AKR/J	MGP_AKRJ_G0016732	protein coding gene	Chr1:176108205-176115410 (+)
BALB/cJ	MGP_BALBcJ_G0016727	protein coding gene	Chr1:171489393-171496877 (+)
C3H/HeJ	MGP_C3HHeJ_G0016551	protein coding gene	Chr1:176681559-176689044 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017189	protein coding gene	Chr1:184156448-184164001 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014895	protein coding gene	Chr1:162646570-162654157 (+)
CAST/EiJ	MGP_CASTEiJ_G0016131	protein coding gene	Chr1:176055992-176063497 (+)
CBA/J	MGP_CBAJ_G0016525	protein coding gene	Chr1:190697403-190707259 (+)
DBA/2J	MGP_DBA2J_G0016632	protein coding gene	Chr1:169879611-169887122 (+)
FVB/NJ	MGP_FVBNJ_G0016629	protein coding gene	Chr1:168135288-168142799 (+)
LP/J	MGP_LPJ_G0016703	protein coding gene	Chr1:179328906-179336401 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016656	protein coding gene	Chr1:197942108-197949665 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017225	protein coding gene	Chr1:175977435-175984922 (+)
PWK/PhJ	MGP_PWKPhJ_G0015917	protein coding gene	Chr1:169258256-169265927 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015699	protein coding gene	Chr1:174927114-174934651 (+)
WSB/EiJ	MGP_WSBEiJ_G0016193	protein coding gene	Chr1:176135872-176143368 (+)

Human Ortholog

PIGM, phosphatidylinositol glycan anchor biosynthesis class M

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PIGM, phosphatidylinositol glycan anchor biosynthesis class M
Synonyms

GPI-MT-I
Links

HGNC:18858

NCBI Gene ID: 93183

neXtProt AC: NX_Q9H3S5

UniProt: Q9H3S5
Chr Location

1q23.2; chr1:160024953-160031990 (-) GRCh38

MGI Vertebrate Homology

Pigm stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PIGM
Gene Tree

Pigm

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

2
Targeted

2
Genomic Mutations

2 involving Pigm
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available

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All GO Annotations

9
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

858
Tissues

121
cDNA Data

19
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pigm

ZFIN pigm

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All Sequences

48
RefSeq

2
UniProt

1
CCDS

CCDS15513.1

Ensembl

ENSMUSG00000050229 (Evidence)
NCBI Gene

67556

			Length	Strain/Species	Flank
genomic	ENSMUSG00000050229	Ensembl Gene Model \| MGI Sequence Detail	7554	C57BL/6J	± kb
transcript	ENSMUST00000052455	Ensembl \| MGI Sequence Detail	7554	Not Applicable
polypeptide	ENSMUSP00000052838	Ensembl \| MGI Sequence Detail	423	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000012700 GPI mannosyltransferase 1

(term hierarchy)
EC

2.4.1.-
InterPro Domains

IPR007704 GPI mannosyltransferase 1

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All nucleic 21

Genomic 2

cDNA 19

Microarray probesets 7

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MGI:2138304, MGI:2138532, MGI:2443074

Summaries

All 37

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pigm:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10193	Chr1:172204095-172204166 (+)	18 bp
Tssr10194	Chr1:172204167-172204191 (+)	66 bp
Tssr10195	Chr1:172204474-172204500 (+)	374 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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