Ciao3 MGI Mouse Gene Detail - MGI:1914813 - cytosolic iron-sulfur assembly component 3

Symbol

Ciao3
Name

cytosolic iron-sulfur assembly component 3
Synonyms

9030612I22Rik, Narfl

Feature Type

protein coding gene
IDs

MGI:1914813
NCBI Gene: 67563
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr17:25992750-26002306 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 12.88 cM
Mapping Data

2 experiments

SNPs within 2kb

273 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914813	protein coding gene	Chr17:25992750-26002306 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023365	protein coding gene	Chr17:24868577-24879425 (+)
A/J	MGP_AJ_G0023324	protein coding gene	Chr17:24146573-24156146 (+)
AKR/J	MGP_AKRJ_G0023290	protein coding gene	Chr17:24249789-24260198 (+)
BALB/cJ	MGP_BALBcJ_G0023329	protein coding gene	Chr17:24371560-24381780 (+)
C3H/HeJ	MGP_C3HHeJ_G0023089	protein coding gene	Chr17:24634327-24643720 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023771	protein coding gene	Chr17:25920939-25932340 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021247	protein coding gene	Chr17:21607497-21617293 (+)
CAST/EiJ	MGP_CASTEiJ_G0022591	protein coding gene	Chr17:24514829-24527837 (+)
CBA/J	MGP_CBAJ_G0023064	protein coding gene	Chr17:26830228-26839685 (+)
DBA/2J	MGP_DBA2J_G0023194	protein coding gene	Chr17:23747237-23756731 (+)
FVB/NJ	MGP_FVBNJ_G0023164	protein coding gene	Chr17:23487128-23497385 (+)
LP/J	MGP_LPJ_G0023271	protein coding gene	Chr17:25166848-25177155 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023183	protein coding gene	Chr17:26446001-26455422 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023811	protein coding gene	Chr17:24569655-24581059 (+)
PWK/PhJ	MGP_PWKPhJ_G0022340	protein coding gene	Chr17:22509006-22519730 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022158	protein coding gene	Chr17:22643524-22653081 (+)
WSB/EiJ	MGP_WSBEiJ_G0022654	protein coding gene	Chr17:24622546-24631994 (+)

Human Ortholog

CIAO3, cytosolic iron-sulfur assembly component 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CIAO3, cytosolic iron-sulfur assembly component 3
Synonyms

HPRN, IOP1, LET1L, NAR1, NARFL, PRN
Links

HGNC:14179

NCBI Gene ID: 64428

neXtProt AC: NX_Q9H6Q4

UniProt: Q9H6Q4
Chr Location

16p13.3; chr16:729760-741329 (-) GRCh38

MGI Vertebrate Homology

Ciao3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CIAO3
Gene Tree

Ciao3

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Phenotype Summary

5 phenotypes from 3 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

2
Targeted

4
Transgenic

1
Genomic Mutations

2 involving Ciao3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available

Mice homozygous for a targeted knock-out die before E10.5. Mice heterozygous for a targeted allele exhibit partial lethality between E10.5 and birth.

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

9
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ciao3

ZFIN narfl

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All Sequences

56
RefSeq

6
UniProt

3
CCDS

CCDS50034.1

Ensembl

ENSMUSG00000002280 (Evidence)
NCBI Gene

67563

			Length	Strain/Species	Flank
genomic	67563	NCBI Gene Model \| MGI Sequence Detail	9557	C57BL/6J	± kb
transcript	NM_026238	RefSeq \| MGI Sequence Detail	2555	C57BL/6
polypeptide	Q7TMW6	UniProt \| EBI \| MGI Sequence Detail	476	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010988 cytosolic iron-sulfur assembly component 3

(term hierarchy)
InterPro Domains

IPR050340 Cytosolic Fe-S Cluster Assembly Factor

IPR009016 Iron hydrogenase

IPR004108 Iron hydrogenase, large subunit, C-terminal

IPR003149 Iron hydrogenase, small subunit

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All nucleic 9

cDNA 9

Microarray probesets 4

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MGI:2146884, MGI:6286362

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Ciao3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143176	Chr17:25992743-25992752 (+)	-2 bp
Tssr143177	Chr17:25992761-25992798 (+)	30 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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