Loxl4 MGI Mouse Gene Detail - MGI:1914823

Symbol

Loxl4
Name

lysyl oxidase-like 4
Synonyms

4833426I20Rik

Feature Type

protein coding gene
IDs

MGI:1914823
NCBI Gene: 67573
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr19:42582421-42601252 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 36.56 cM, cytoband D1
Mapping Data

2 experiments

SNPs within 2kb

739 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914823	protein coding gene	Chr19:42580718-42601326 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025147	protein coding gene	Chr19:41932414-41951455 (-)
A/J	MGP_AJ_G0025124	protein coding gene	Chr19:39922731-39941426 (-)
AKR/J	MGP_AKRJ_G0025092	protein coding gene	Chr19:41213370-41232074 (-)
BALB/cJ	MGP_BALBcJ_G0025118	protein coding gene	Chr19:39980751-40000278 (-)
C3H/HeJ	MGP_C3HHeJ_G0024878	protein coding gene	Chr19:41368763-41387468 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025561	protein coding gene	Chr19:43006192-43031644 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022975	protein coding gene	Chr19:39275371-39294239 (-)
CAST/EiJ	MGP_CASTEiJ_G0024343	protein coding gene	Chr19:41067454-41086233 (-)
CBA/J	MGP_CBAJ_G0024858	protein coding gene	Chr19:45086460-45105156 (-)
DBA/2J	MGP_DBA2J_G0024990	protein coding gene	Chr19:39763048-39781735 (-)
FVB/NJ	MGP_FVBNJ_G0024951	protein coding gene	Chr19:39537744-39556478 (-)
LP/J	MGP_LPJ_G0025076	protein coding gene	Chr19:41916911-41935617 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024982	protein coding gene	Chr19:44703931-44722640 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025619	protein coding gene	Chr19:41278813-41297418 (-)
PWK/PhJ	MGP_PWKPhJ_G0024092	protein coding gene	Chr19:39664113-39683689 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023896	protein coding gene	Chr19:40019445-40040245 (-)
WSB/EiJ	MGP_WSBEiJ_G0024413	protein coding gene	Chr19:41418083-41436798 (-)

Human Ortholog

LOXL4, lysyl oxidase like 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LOXL4, lysyl oxidase like 4
Synonyms

LOXC
Links

HGNC:17171

NCBI Gene ID: 84171

neXtProt AC: NX_Q96JB6

UniProt: Q96JB6
Chr Location

10q24.2; chr10:98247690-98268194 (-) GRCh38

MGI Vertebrate Homology

Loxl4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LOXL4
Gene Tree

Loxl4

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

4
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele have normal lysyl oxidase enzyme activity in the heart and aorta tissues and show normal development of angiotensin II-induced thoracic and abdominal aortic aneurysms.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

812
Tissues

21
cDNA Data

15
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

52
RefSeq

8
UniProt

7
CCDS

CCDS29830.1, CCDS50441.1

Ensembl

ENSMUSG00000025185 (Evidence)
NCBI Gene

67573

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025185	Ensembl Gene Model \| MGI Sequence Detail	18832	C57BL/6J	± kb
transcript	ENSMUST00000164786	Ensembl \| MGI Sequence Detail	2617	Not Applicable
polypeptide	ENSMUSP00000125803	Ensembl \| MGI Sequence Detail	758	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000009887 lysyl oxidase homolog 4

(term hierarchy)
EC

1.4.3.13
InterPro Domains

IPR001695 Lysyl oxidase

IPR019828 Lysyl oxidase, conserved site

IPR050912 Lysyl oxidase-like protein

IPR001190 SRCR domain

IPR017448 SRCR-like domain

IPR036772 SRCR-like domain superfamily
GlyGen

Q924C6 2 sites

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All nucleic 16

cDNA 15

Primer pair 1

Microarray probesets 3

Summaries

All 36

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Loxl4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr159363	Chr19:42601205-42601220 (-)	39 bp
Tssr159362	Chr19:42588490-42588497 (-)	12,758 bp
Tssr159361	Chr19:42588388-42588398 (-)	12,859 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24