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Tbc1d23 Gene Detail
Summary
  • Symbol
    Tbc1d23
  • Name
    TBC1 domain family, member 23
  • Synonyms
    4930451A13Rik, D030022P07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914831
    NCBI Gene: 67581
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:56989225-57051867 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 34.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1806 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914831
 protein coding gene Chr16:56989225-57051891 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022896
 protein coding gene Chr16:56320062-56378978 (-)
A/J MGP_AJ_G0022863
 protein coding gene Chr16:53905828-53961131 (-)
AKR/J MGP_AKRJ_G0022835
 protein coding gene Chr16:55609143-55665094 (-)
BALB/cJ MGP_BALBcJ_G0022863
 protein coding gene Chr16:54009445-54065039 (-)
C3H/HeJ MGP_C3HHeJ_G0022626
 protein coding gene Chr16:55799428-55860127 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023311
 protein coding gene Chr16:57883346-57945736 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020822
 protein coding gene Chr16:53557409-53611675 (-)
CAST/EiJ MGP_CASTEiJ_G0022153
 protein coding gene Chr16:56185297-56244291 (-)
CBA/J MGP_CBAJ_G0022599
 protein coding gene Chr16:60228247-60290801 (-)
DBA/2J MGP_DBA2J_G0022731
 protein coding gene Chr16:53643215-53700350 (-)
FVB/NJ MGP_FVBNJ_G0022706
 protein coding gene Chr16:53402825-53465882 (-)
LP/J MGP_LPJ_G0022798
 protein coding gene Chr16:56143496-56198866 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022724
 protein coding gene Chr16:60571630-60630004 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023326
 protein coding gene Chr16:55753390-55810454 (-)
PWK/PhJ MGP_PWKPhJ_G0021892
 protein coding gene Chr16:53953733-54010431 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021722
 protein coding gene Chr16:55532444-55591351 (-)
WSB/EiJ MGP_WSBEiJ_G0022197
 protein coding gene Chr16:55798280-55858648 (-)



Homology
more
  • Human Ortholog
    TBC1D23, TBC1 domain family member 23
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBC1D23, TBC1 domain family member 23
  • Synonyms
    NS4ATP1, PCH11
  • Links
    NCBI Gene ID: 55773
    neXtProt AC: NX_Q9NUY8
    UniProt: Q9NUY8

  • Chr Location
    3q12.1-q12.2; chr3:100260992-100325251 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TBC1D23 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit increased serum cytokine production and inflammatory cells in the peritoneum following i.p. lipopolysaccharide injection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    106
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022749 Ensembl Gene Model | MGI Sequence Detail 62643 C57BL/6J ±  kb
    transcript ENSMUST00000226586 Ensembl | MGI Sequence Detail 3112 Not Applicable  
    polypeptide ENSMUSP00000154535 Ensembl | MGI Sequence Detail 699 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      cDNA 109
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2146539, MGI:2146578, MGI:2146579, MGI:2146737, MGI:2444361
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory