Slc25a26 MGI Mouse Gene Detail - MGI:1914832 - solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26

Symbol

Slc25a26
Name

solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26
Synonyms

4930433D19Rik, 4933433F13Rik, D6Bwg0781e

Feature Type

protein coding gene
IDs

MGI:1914832
NCBI Gene: 67582
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr6:94477312-94581653 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 43.13 cM, cytoband D3
Mapping Data

4 experiments

SNPs within 2kb

3015 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914832	protein coding gene	Chr6:94477272-94581653 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031064	protein coding gene	Chr6:96261683-96371950 (+)
A/J	MGP_AJ_G0031033	protein coding gene	Chr6:92608070-92713629 (+)
AKR/J	MGP_AKRJ_G0030964	protein coding gene	Chr6:95149156-95258888 (+)
BALB/cJ	MGP_BALBcJ_G0031044	protein coding gene	Chr6:92559766-92665154 (+)
C3H/HeJ	MGP_C3HHeJ_G0030664	protein coding gene	Chr6:89154245-89264488 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031503	protein coding gene	Chr6:98685033-98792603 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028669	protein coding gene	Chr6:90563564-90665529 (+)
CAST/EiJ	MGP_CASTEiJ_G0030151	protein coding gene	Chr6:95357543-95466091 (+)
CBA/J	MGP_CBAJ_G0030730	protein coding gene	Chr6:102444724-102561264 (+)
DBA/2J	MGP_DBA2J_G0030883	protein coding gene	Chr6:91756482-91861877 (+)
FVB/NJ	MGP_FVBNJ_G0030837	protein coding gene	Chr6:90972091-91077722 (+)
LP/J	MGP_LPJ_G0030963	protein coding gene	Chr6:96242917-96351179 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030871	protein coding gene	Chr6:106399344-106512624 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031530	protein coding gene	Chr6:95026502-95128636 (+)
PWK/PhJ	MGP_PWKPhJ_G0029867	protein coding gene	Chr6:90764181-90875214 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029696	protein coding gene	Chr6:93956514-94065713 (+)
WSB/EiJ	MGP_WSBEiJ_G0030235	protein coding gene	Chr6:95493660-95600459 (+)

Human Ortholog

SLC25A26, solute carrier family 25 member 26

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC25A26, solute carrier family 25 member 26
Synonyms

COXPD28, SAMC
Links

HGNC:20661

NCBI Gene ID: 115286

neXtProt AC: NX_Q70HW3

UniProt: Q70HW3
Chr Location

3p14.1; chr3:66133610-66388116 (+) GRCh38

MGI Vertebrate Homology

Slc25a26 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC25A26
Gene Tree

Slc25a26

Diseases

1 with human SLC25A26 associations

				Human Disease	Mouse Models
				combined oxidative phosphorylation deficiency 28 IDs combined oxidative phosphorylation deficiency 28 DOID:0111470 OMIM:616794 ORDO:466784

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

1
Gene trapped

5
Spontaneous

1
Targeted

2
Transposon induced

1
Genomic Mutations

1 involving Slc25a26
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available

Embryos homozygous for a transposon insertion appear growth retarded and underdeveloped and die after E8.5 but prior to birth.

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All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

38
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc25a26

ZFIN slc25a26

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All Sequences

69
RefSeq

19
UniProt

4
CCDS

CCDS20379.1

Ensembl

ENSMUSG00000045100 (Evidence)
NCBI Gene

67582

			Length	Strain/Species	Flank
genomic	ENSMUSG00000045100	Ensembl Gene Model \| MGI Sequence Detail	104342	C57BL/6J	± kb
transcript	ENSMUST00000061118	Ensembl \| MGI Sequence Detail	1922	Not Applicable
polypeptide	ENSMUSP00000058028	Ensembl \| MGI Sequence Detail	274	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015022 mitochondrial S-adenosylmethionine carrier protein

(term hierarchy)
InterPro Domains

IPR023395 Mitochondrial carrier domain superfamily

IPR002067 Mitochondrial carrier protein

IPR018108 Mitochondrial substrate/solute carrier
GlyGen

Q5U680 1 site, 1 O-linked glycan (1 site)

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All nucleic 39

cDNA 38

Primer pair 1

Microarray probesets 5

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MGD-MRK-34162, MGI:106468, MGI:1918503, MGI:2141709

Summaries

All 40

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 12
Earliest

J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
Latest

J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)

TSS for Slc25a26:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57808	Chr6:94477294-94477334 (+)	2 bp
Tssr57809	Chr6:94477338-94477352 (+)	33 bp
Tssr57810	Chr6:94477368-94477379 (+)	62 bp
Tssr57811	Chr6:94569327-94569340 (+)	92,022 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24