Mettl9 MGI Mouse Gene Detail - MGI:1914862

Symbol

Mettl9
Name

methyltransferase like 9
Synonyms

0610012D09Rik, Drev

Feature Type

protein coding gene
IDs

MGI:1914862
NCBI Gene: 59052
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr7:120633668-120677552 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 65.07 cM
Mapping Data

2 experiments

SNPs within 2kb

868 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914862	protein coding gene	Chr7:120631717-120677552 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032939	protein coding gene	Chr7:125053723-125096980 (+)
A/J	MGP_AJ_G0032922	protein coding gene	Chr7:121790018-121832521 (+)
AKR/J	MGP_AKRJ_G0032854	protein coding gene	Chr7:124914661-124957050 (+)
BALB/cJ	MGP_BALBcJ_G0032927	protein coding gene	Chr7:121507527-121550227 (+)
C3H/HeJ	MGP_C3HHeJ_G0032637	protein coding gene	Chr7:124830652-124873018 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033433	protein coding gene	Chr7:130000166-130042659 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030405	protein coding gene	Chr7:123161980-123203994 (+)
CAST/EiJ	MGP_CASTEiJ_G0031965	protein coding gene	Chr7:116593067-116635593 (+)
CBA/J	MGP_CBAJ_G0032610	protein coding gene	Chr7:134329368-134374470 (+)
DBA/2J	MGP_DBA2J_G0032762	protein coding gene	Chr7:119823432-119865821 (+)
FVB/NJ	MGP_FVBNJ_G0032715	protein coding gene	Chr7:119682297-119724686 (+)
LP/J	MGP_LPJ_G0032856	protein coding gene	Chr7:126494830-126537281 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032747	protein coding gene	Chr7:135794436-135837698 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033453	protein coding gene	Chr7:123908378-123951357 (+)
PWK/PhJ	MGP_PWKPhJ_G0031673	protein coding gene	Chr7:112752463-112795074 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031519	protein coding gene	Chr7:110669369-110711649 (+)
WSB/EiJ	MGP_WSBEiJ_G0032078	protein coding gene	Chr7:124834117-124876506 (+)

Human Ortholog

METTL9, methyltransferase 9, His-X-His N1(pi)-histidine

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

METTL9, methyltransferase 9, His-X-His N1(pi)-histidine
Synonyms

CGI-81, DREV, DREV1, hMETTL9, PAP1
Links

HGNC:24586

NCBI Gene ID: 51108

neXtProt AC: NX_Q9H1A3

UniProt: Q9H1A3
Chr Location

16p12.2; chr16:21597208-21657471 (+) GRCh38

MGI Vertebrate Homology

Mettl9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: METTL9
Gene Tree

Mettl9

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

4
Gene trapped

4
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

17 strains or lines available

Mice exhibit reduced 1MH methylation without any abnormal phenotype.

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All GO Annotations

6
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

5
cDNA Data

9
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mettl9

ZFIN mettl9

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All Sequences

117
RefSeq

42
UniProt

3
CCDS

CCDS21800.1

Ensembl

ENSMUSG00000030876 (Evidence)
NCBI Gene

59052

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030876	Ensembl Gene Model \| MGI Sequence Detail	43885	C57BL/6J	± kb
transcript	ENSMUST00000033163	Ensembl \| MGI Sequence Detail	1823	Not Applicable
polypeptide	ENSMUSP00000033163	Ensembl \| MGI Sequence Detail	318	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010355 protein-L-histidine N-pros-methyltransferase

(term hierarchy)
EC

2.1.1.-
InterPro Domains

IPR007884 Protein-L-histidine N-pros-methyltransferase

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
GlyGen

Q9EPL4 1 site, 1 N-linked glycan (1 site)

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All nucleic 10

cDNA 10

Microarray probesets 5

Summaries

All 34

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 7
Earliest

J:67662 Bates EE, et al., The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function. Immunogenetics. 2000 Nov;52(1-2):112-20
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Mettl9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68813	Chr7:120633639-120633644 (+)	-26 bp
Tssr68814	Chr7:120633743-120633752 (+)	80 bp
Tssr68815	Chr7:120633765-120633803 (+)	116 bp
Tssr68816	Chr7:120633804-120633941 (+)	205 bp
Tssr68817	Chr7:120633962-120633988 (+)	307 bp
Tssr68818	Chr7:120634005-120634016 (+)	343 bp
Tssr68819	Chr7:120634783-120634789 (+)	1,118 bp
Tssr68820	Chr7:120634842-120634883 (+)	1,195 bp
Tssr68821	Chr7:120635889-120635896 (+)	2,225 bp
Tssr68822	Chr7:120645228-120645241 (+)	11,567 bp
Tssr68824	Chr7:120664339-120664359 (+)	30,681 bp
Tssr68825	Chr7:120673856-120673871 (+)	40,196 bp
Tssr68826	Chr7:120673874-120673885 (+)	40,212 bp
Tssr68827	Chr7:120673889-120673896 (+)	40,225 bp
Tssr68828	Chr7:120673908-120673936 (+)	40,254 bp
Tssr68829	Chr7:120673945-120673956 (+)	40,283 bp
Tssr68830	Chr7:120674518-120674552 (+)	40,867 bp
Tssr68831	Chr7:120675035-120675046 (+)	41,373 bp
Tssr68832	Chr7:120675064-120675081 (+)	41,405 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24