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Anp32b Gene Detail
Summary
  • Symbol
    Anp32b
  • Name
    acidic nuclear phosphoprotein 32 family member B
  • Synonyms
    2410015B15Rik, PAL31, PHAPI2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914878
    NCBI Gene: 67628
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:46450926-46472657 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 24.79 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    527 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914878
 protein coding gene Chr4:46450902-46472657 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028258
 protein coding gene Chr4:44766242-44791353 (+)
A/J MGP_AJ_G0028217
 protein coding gene Chr4:43123142-43145787 (+)
AKR/J MGP_AKRJ_G0028167
 protein coding gene Chr4:44177432-44199123 (+)
BALB/cJ MGP_BALBcJ_G0028237
 protein coding gene Chr4:43228233-43250323 (+)
C3H/HeJ MGP_C3HHeJ_G0027958
 protein coding gene Chr4:44788380-44810117 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028678
 protein coding gene Chr4:46420388-46444345 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025987
 protein coding gene Chr4:40503723-40525203 (+)
CAST/EiJ MGP_CASTEiJ_G0027397
 protein coding gene Chr4:44339400-44362741 (+)
CBA/J MGP_CBAJ_G0027924
 protein coding gene Chr4:47898934-47925016 (+)
DBA/2J MGP_DBA2J_G0028074
 protein coding gene Chr4:43015848-43037234 (+)
FVB/NJ MGP_FVBNJ_G0028041
 protein coding gene Chr4:42264968-42286805 (+)
LP/J MGP_LPJ_G0028173
 protein coding gene Chr4:44816652-44841297 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028065
 protein coding gene Chr4:50977325-50998948 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028713
 protein coding gene Chr4:44397959-44419440 (+)
PWK/PhJ MGP_PWKPhJ_G0027122
 protein coding gene Chr4:43119625-43141823 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026950
 protein coding gene Chr4:43899786-43921590 (+)
WSB/EiJ MGP_WSBEiJ_G0027475
 protein coding gene Chr4:44309632-44331901 (+)



Homology
more
  • Human Ortholog
    ANP32B, acidic nuclear phosphoprotein 32 family member B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANP32B, acidic nuclear phosphoprotein 32 family member B
  • Synonyms
    APRIL, PHAPI2, SSP29
  • Links
    NCBI Gene ID: 10541
    neXtProt AC: NX_Q92688
    UniProt: Q92688

  • Chr Location
    9q22.33; chr9:97983341-98015943 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 1 allele in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit background-sensitive partial perinatal lethality with failure to initiate breathing, craniofacial defects, enlarged brain ventricle, expanded inner ear cavities, plate closure defects, decreased body weight, premature aging, and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    54
  • cDNA Data
    168
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67628 NCBI Gene Model | MGI Sequence Detail 21732 C57BL/6J ±  kb
    transcript NM_130889 RefSeq | MGI Sequence Detail 1702 C57BL/6  
    polypeptide Q9EST5 UniProt | EBI | MGI Sequence Detail 272 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004066 acidic leucine-rich nuclear phosphoprotein 32 family member B
      (term hierarchy)
    • InterPro Domains
      IPR045081 Acidic leucine-rich nuclear phosphoprotein 32
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003603 U2A'/phosphoprotein 32 family A, C-terminal
    • GlyGen
      Q9EST5 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 173
      Genomic 1
      cDNA 169
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1926203
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:64959 Misawa K, et al., A method to identify cDNAs based on localization of green fluorescent protein fusion products. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3062-6
    • Latest
      J:342644 Tscherner AK, et al., Relationship of quantitative reverse transcription polymerase chain reaction (RT-PCR) to RNA Sequencing (RNAseq) transcriptome identifies mouse preimplantation embryo reference genes. Biol Reprod. 2023 Nov 15;109(5):601-617
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory