Rnf125 MGI Mouse Gene Detail - MGI:1914914

Symbol

Rnf125
Name

ring finger protein 125
Synonyms

4930553F04Rik

Feature Type

protein coding gene
IDs

MGI:1914914
NCBI Gene: 67664
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr18:21077682-21116919 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 11.67 cM, cytoband A2
Mapping Data

2 experiments

SNPs within 2kb

1321 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914914	protein coding gene	Chr18:21077672-21120416 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024185	protein coding gene	Chr18:18562807-18594416 (+)
A/J	MGP_AJ_G0024149	protein coding gene	Chr18:18085579-18111398 (+)
AKR/J	MGP_AKRJ_G0024118	protein coding gene	Chr18:18636728-18664647 (+)
BALB/cJ	MGP_BALBcJ_G0024149	protein coding gene	Chr18:18146354-18167531 (+)
C3H/HeJ	MGP_C3HHeJ_G0023917	protein coding gene	Chr18:18577922-18602802 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024591	protein coding gene	Chr18:19459087-19483994 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022033	protein coding gene	Chr18:17197880-17220105 (+)
CAST/EiJ	MGP_CASTEiJ_G0023390	protein coding gene	Chr18:18338057-18389727 (+)
CBA/J	MGP_CBAJ_G0023885	protein coding gene	Chr18:19918457-19975879 (+)
DBA/2J	MGP_DBA2J_G0024017	protein coding gene	Chr18:17796099-17817657 (+)
FVB/NJ	MGP_FVBNJ_G0023983	protein coding gene	Chr18:17573267-17594700 (+)
LP/J	MGP_LPJ_G0024098	protein coding gene	Chr18:18729968-18753526 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024011	protein coding gene	Chr18:20841283-20871061 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024639	protein coding gene	Chr18:18396039-18421069 (+)
PWK/PhJ	MGP_PWKPhJ_G0023135	protein coding gene	Chr18:17879235-17919904 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022944	protein coding gene	Chr18:18604366-18633427 (+)
WSB/EiJ	MGP_WSBEiJ_G0023455	protein coding gene	Chr18:18323058-18347823 (+)

Human Ortholog

RNF125, ring finger protein 125

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNF125, ring finger protein 125
Synonyms

TNORS, TRAC-1, TRAC1
Links

HGNC:21150

NCBI Gene ID: 54941

neXtProt AC: NX_Q96EQ8

UniProt: Q96EQ8
Chr Location

18q12.1; chr18:32018825-32088144 (+) GRCh38

MGI Vertebrate Homology

Rnf125 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RNF125
Gene Tree

Rnf125

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

47
Endonuclease-mediated

1
Gene trapped

43
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

55 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

29
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

742
Tissues

2
cDNA Data

10
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rnf125

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All Sequences

42
RefSeq

4
UniProt

2
CCDS

CCDS29088.1, CCDS89199.1

Ensembl

ENSMUSG00000033107 (Evidence)
NCBI Gene

67664

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033107	Ensembl Gene Model \| MGI Sequence Detail	39238	C57BL/6J	± kb
transcript	ENSMUST00000234316	Ensembl \| MGI Sequence Detail	1406	Not Applicable
polypeptide	ENSMUSP00000157304	Ensembl \| MGI Sequence Detail	233	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014077 E3 ubiquitin-protein ligase RNF125

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR008598 Drought induced 19 protein type, zinc-binding domain

IPR051438 RNF E3 ubiquitin-protein ligase

IPR034734 Zinc finger C2HC RNF-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

IPR027370 Zinc finger, RING-type, eukaryotic

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All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 4

Summaries

All 39

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rnf125:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150198	Chr18:21077664-21077682 (+)	-9 bp
Tssr150199	Chr18:21094299-21094306 (+)	16,621 bp
Tssr150200	Chr18:21094313-21094324 (+)	16,637 bp
Tssr150201	Chr18:21094333-21094347 (+)	16,658 bp
Tssr150202	Chr18:21094359-21094407 (+)	16,701 bp
Tssr150203	Chr18:21094413-21094438 (+)	16,744 bp
Tssr150204	Chr18:21094480-21094524 (+)	16,820 bp
Tssr150205	Chr18:21094537-21094568 (+)	16,871 bp
Tssr150206	Chr18:21094624-21094646 (+)	16,953 bp
Tssr150207	Chr18:21094651-21094694 (+)	16,991 bp
Tssr150208	Chr18:21094802-21094811 (+)	17,125 bp
Tssr150209	Chr18:21095506-21095522 (+)	17,832 bp
Tssr150210	Chr18:21095738-21095743 (+)	18,059 bp
Tssr150211	Chr18:21095863-21095875 (+)	18,187 bp
Tssr150212	Chr18:21095926-21095933 (+)	18,248 bp
Tssr150213	Chr18:21095945-21095958 (+)	18,270 bp
Tssr150214	Chr18:21096181-21096185 (+)	18,501 bp
Tssr150215	Chr18:21104709-21104719 (+)	27,032 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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