Rpl38 MGI Mouse Gene Detail - MGI:1914921

Symbol

Rpl38
Name

ribosomal protein L38
Synonyms

0610025G13Rik, Rbt, Ts, Tss

Feature Type

protein coding gene
IDs

MGI:1914921
NCBI Gene: 67671
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:114559350-114563157 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 79.82 cM, cytoband G1
Mapping Data

15 experiments

SNPs within 2kb

215 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914921	protein coding gene	Chr11:114558644-114563159 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019356	protein coding gene	Chr11:118591948-118596541 (+)
A/J	MGP_AJ_G0019325	protein coding gene	Chr11:113440345-113445296 (+)
AKR/J	MGP_AKRJ_G0019293	protein coding gene	Chr11:116786893-116791883 (+)
BALB/cJ	MGP_BALBcJ_G0019298	protein coding gene	Chr11:113861334-113865141 (+)
C3H/HeJ	MGP_C3HHeJ_G0019107	protein coding gene	Chr11:117141130-117145616 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019749	protein coding gene	Chr11:122146831-122150638 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017372	protein coding gene	Chr11:110507964-110511781 (+)
CAST/EiJ	MGP_CASTEiJ_G0018661	protein coding gene	Chr11:118459579-118469335 (+)
CBA/J	MGP_CBAJ_G0019077	protein coding gene	Chr11:127036423-127040403 (+)
DBA/2J	MGP_DBA2J_G0019189	protein coding gene	Chr11:112881214-112886646 (+)
FVB/NJ	MGP_FVBNJ_G0019180	protein coding gene	Chr11:112361461-112365268 (+)
LP/J	MGP_LPJ_G0019259	protein coding gene	Chr11:119003067-119007096 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019211	protein coding gene	Chr11:126194132-126197939 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019786	protein coding gene	Chr11:117464095-117467902 (+)
PWK/PhJ	MGP_PWKPhJ_G0018426	protein coding gene	Chr11:114116938-114121412 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018218	protein coding gene	Chr11:117266562-117270372 (+)
WSB/EiJ	MGP_WSBEiJ_G0018713	protein coding gene	Chr11:117423285-117429805 (+)

Human Ortholog

RPL38, ribosomal protein L38

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPL38, ribosomal protein L38
Synonyms

eL38, L38
Links

HGNC:10349

NCBI Gene ID: 6169

neXtProt AC: NX_P63173

UniProt: P63173
Chr Location

17q25.1; chr17:74203582-74210655 (+) GRCh38

MGI Vertebrate Homology

Rpl38 stringent orthology
1 human;1 mouse;5 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPL38
Gene Tree

Rpl38

Diseases

1 with Rpl38 mouse models

Human Disease

Mouse Models

otitis media

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

103 phenotypes from 3 alleles in 22 genetic backgrounds
3 phenotypes from multigenic genotypes
2 images
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

79
Chemically induced (ENU)

1
Gene trapped

73
Spontaneous

2
Targeted

3
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutations in this gene affect growth and tail formation, and result in anterior and posterior homeotic vertebral transformations along the axial skeleton along with other abnormalities depending on genetic background. Homozygotes die in the early embryonic period.

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All GO Annotations

37
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

2
cDNA Data

12
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rpl38

ZFIN rpl38

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All Sequences

61
RefSeq

10
UniProt

2
CCDS

CCDS36365.1

Ensembl

ENSMUSG00000057322 (Evidence)
NCBI Gene

67671

			Length	Strain/Species	Flank
genomic	ENSMUSG00000057322	Ensembl Gene Model \| MGI Sequence Detail	3808	C57BL/6J	± kb
transcript	ENSMUST00000082092	Ensembl \| MGI Sequence Detail	345	Not Applicable
polypeptide	ENSMUSP00000080741	Ensembl \| MGI Sequence Detail	70	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014224 large ribosomal subunit protein eL38

(term hierarchy)
PDB

6SWA, 7CPU, 7CPV, 7LS1, 7LS2
InterPro Domains

IPR002675 Large ribosomal subunit protein eL38

IPR038464 Large ribosomal subunit protein eL38 superfamily
GlyGen

Q9JJI8 1 site, 1 O-linked glycan (1 site)

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 8

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MGD-MRK-15255, MGD-MRK-37425, MGI:108385, MGI:1859966, MGI:98840

Summaries

All 57

Developmental Gene Expression 3

Diseases 1

Gene Ontology 11

Phenotypes 25
Earliest

J:13063 MORGAN WC, A new tail-short mutation in the mouse whose lethal effects are conditioned by the residual genotypes. J Hered. 1950 Aug;41(8):208-15
Latest

J:333015 Li H, et al., A male germ-cell-specific ribosome controls male fertility. Nature. 2022 Dec;612(7941):725-731

TSS for Rpl38:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105774	Chr11:114557824-114557857 (+)	-1,509 bp
Tssr105775	Chr11:114559396-114559433 (+)	65 bp
Tssr105776	Chr11:114559579-114559600 (+)	240 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24