Aldh3b1 MGI Mouse Gene Detail - MGI:1914939 - aldehyde dehydrogenase 3 family, member B1

Symbol

Aldh3b1
Name

aldehyde dehydrogenase 3 family, member B1
Synonyms

1700001N19Rik, ALDH4, ALDH7

Feature Type

protein coding gene
IDs

MGI:1914939
NCBI Gene: 67689
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr19:3963491-3979808 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 3.63 cM
Mapping Data

1 experiment

SNPs within 2kb

389 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914939	protein coding gene	Chr19:3963491-3980898 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024633	protein coding gene	Chr19:721965-738233 (-)
A/J	MGP_AJ_G0024600	protein coding gene	Chr19:689018-705285 (-)
AKR/J	MGP_AKRJ_G0024571	protein coding gene	Chr19:698386-715050 (-)
BALB/cJ	MGP_BALBcJ_G0024598	protein coding gene	Chr19:699191-715458 (-)
C3H/HeJ	MGP_C3HHeJ_G0024367	protein coding gene	Chr19:699611-716816 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025046	protein coding gene	Chr19:724076-743153 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022475	protein coding gene	Chr19:654796-671080 (-)
CAST/EiJ	MGP_CASTEiJ_G0023839	protein coding gene	Chr19:713613-730723 (-)
CBA/J	MGP_CBAJ_G0024337	protein coding gene	Chr19:790400-809351 (-)
DBA/2J	MGP_DBA2J_G0024466	protein coding gene	Chr19:666731-683001 (-)
FVB/NJ	MGP_FVBNJ_G0024433	protein coding gene	Chr19:676259-693068 (-)
LP/J	MGP_LPJ_G0024552	protein coding gene	Chr19:714792-731062 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024463	protein coding gene	Chr19:756769-773035 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025094	protein coding gene	Chr19:704574-721674 (-)
PWK/PhJ	MGP_PWKPhJ_G0023585	protein coding gene	Chr19:691048-712889 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023392	protein coding gene	Chr19:711898-727762 (-)
WSB/EiJ	MGP_WSBEiJ_G0023902	protein coding gene	Chr19:695523-713780 (-)

Human Ortholog

ALDH3B1, aldehyde dehydrogenase 3 family member B1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ALDH3B1, aldehyde dehydrogenase 3 family member B1
Synonyms

ALDH4, ALDH7
Links

HGNC:410

NCBI Gene ID: 221

neXtProt AC: NX_P43353

UniProt: P43353
Chr Location

11q13.2; chr11:68008547-68029282 (+) GRCh38

MGI Vertebrate Homology

Aldh3b1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ALDH3B1
Protein SuperFamily

ALDH
Gene Tree

Aldh3b1

less

Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

2
Gene trapped

4
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

22
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

28
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ALDH3B2

Xenbase aldh3b1

ZFIN aldh3b1

less

All Sequences

45
RefSeq

4
UniProt

4
CCDS

CCDS29403.1

Ensembl

ENSMUSG00000024885 (Evidence)
NCBI Gene

67689

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024885	Ensembl Gene Model \| MGI Sequence Detail	16318	C57BL/6J	± kb
transcript	ENSMUST00000051803	Ensembl \| MGI Sequence Detail	1924	Not Applicable
polypeptide	ENSMUSP00000056276	Ensembl \| MGI Sequence Detail	468	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000031186 aldehyde dehydrogenase family 3 member B1

(term hierarchy)
EC

1.2.1.28, 1.2.1.5, 1.2.1.7
InterPro Domains

IPR016163 Aldehyde dehydrogenase, C-terminal

IPR016160 Aldehyde dehydrogenase, cysteine active site

IPR015590 Aldehyde dehydrogenase domain

IPR029510 Aldehyde dehydrogenase, glutamic acid active site

IPR012394 Aldehyde dehydrogenase NAD(P)-dependent

IPR016162 Aldehyde dehydrogenase, N-terminal

IPR016161 Aldehyde/histidinol dehydrogenase

less

All nucleic 28

cDNA 28

Microarray probesets 3

Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Aldh3b1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157428	Chr19:3980802-3980814 (-)	-1,000 bp
Tssr157427	Chr19:3979767-3979783 (-)	33 bp
Tssr157426	Chr19:3979723-3979765 (-)	64 bp
Tssr157425	Chr19:3968677-3968711 (-)	11,114 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24