Kirrel3 MGI Mouse Gene Detail - MGI:1914953 - kirre like nephrin family adhesion molecule 3

Symbol

Kirrel3
Name

kirre like nephrin family adhesion molecule 3
Synonyms

1500010O20Rik, 2900036G11Rik, mKIAA1867, Neph2

Feature Type

protein coding gene
IDs

MGI:1914953
NCBI Gene: 67703
Alliance

genome feature page
Transcription Start Sites

9 TSS

Sequence Map

Chr9:34397190-34948012 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 18.97 cM
Mapping Data

1 experiment

SNPs within 2kb

15167 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914953	protein coding gene	Chr9:34396850-34952103 (+)
129S1/SvImJ	ENSMUSGG00200054578	protein coding gene	Chr9:31824665-31949669 (+)
A/J	ENSMUSGG00195055032	protein coding gene	Chr9:31616055-31741088 (+)
AKR/J	ENSMUSGG00220054430	protein coding gene	Chr9:31651272-31776721 (+)
BALB/cJ	ENSMUSGG00180055146	protein coding gene	Chr9:31744384-31869404 (+)
C3H/HeJ	ENSMUSGG00175054696	protein coding gene	Chr9:31745625-31870633 (+)
C57BL/6NJ	ENSMUSGG00215055337	protein coding gene	Chr9:31721501-31846446 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031947	protein coding gene	Chr9:30142533-30698104 (+)
CAST/EiJ	ENSTCUGG00005053937	protein coding gene	Chr9:31716398-31842505 (+)
CBA/J	ENSMUSGG00210054484	protein coding gene	Chr9:31745962-31877803 (+)
DBA/2J	ENSMUSGG00185057554	protein coding gene	Chr9:31791472-31916739 (+)
FVB/NJ	ENSMUSGG00205054200	protein coding gene	Chr9:32111149-32236164 (+)
JF1/MsJ	ENSUMUGG00000058155	protein coding gene	Chr9:31989259-32112928 (+)
LP/J	ENSMUSG00230026137	protein coding gene	Chr9:31796377-32351884 (+)
NOD/ShiLtJ	ENSMUSGG00190055027	protein coding gene	Chr9:31869296-31994231 (+)
NZO/HlLtJ	ENSMUSGG00225055305	protein coding gene	Chr9:32192173-32315791 (+)
PWK/PhJ	ENSLUMGG00010053905	protein coding gene	Chr9:31871205-31994720 (+)
SPRET/EiJ	ENSMSPG00010027250	protein coding gene	Chr9:32295363-32422416 (+)
WSB/EiJ	ENSIUOGG00005054016	protein coding gene	Chr9:31317284-31442742 (+)

Human Ortholog

KIRREL3, kirre like nephrin family adhesion molecule 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIRREL3, kirre like nephrin family adhesion molecule 3
Synonyms

KIRRE, MRD4, NEPH2, PRO4502
Links

HGNC:23204

NCBI Gene ID: 84623

UniProt: Q8IZU9
Chr Location

11q24.2; chr11:126423358-127003460 (-) GRCh38

MGI Vertebrate Homology

Kirrel3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KIRREL3
Gene Tree

Kirrel3

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
5 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

3
Gene trapped

1
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired accessory olfactory bulb formation with reduced coalescence of vomeronasal sensory neuron axons in the posterior accessory olfactory bulb, loss of male-male aggression and abnormal male sexual response to a male intruder mouse.

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All GO Annotations

32
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

821
Tissues

172
cDNA Data

14
Literature Summary

19

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kirrel3

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All Sequences

135
RefSeq

60
UniProt

8
CCDS

CCDS40574.1, CCDS57667.1, CCDS80973.1

Ensembl

ENSMUSG00000032036 (Evidence)
NCBI Gene

67703

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032036	Ensembl Gene Model \| MGI Sequence Detail	550823	C57BL/6J	± kb
transcript	ENSMUST00000187182	Ensembl \| MGI Sequence Detail	3532	Not Applicable
polypeptide	ENSMUSP00000140219	Ensembl \| MGI Sequence Detail	777	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000009343 kin of IRRE-like protein 3

(term hierarchy)
PDB

7LU6
InterPro Domains

IPR013162 CD80-like, immunoglobulin C2-set

IPR051275 Cellular adhesion and signaling domain-containing protein

IPR003599 Immunoglobulin domain subtype

IPR013098 Immunoglobulin I-set

IPR013151 Immunoglobulin-like beta-sandwich domain

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003598 Immunoglobulin subtype 2
GlyGen

Q8BR86 4 sites, 3 N-linked glycans (2 sites)

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All nucleic 20

cDNA 15

Primer pair 1

Other 4

Antibodies 2

Microarray probesets 4

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MGI:1920101

Summaries

All 68

Developmental Gene Expression 19

Gene Ontology 11

Phenotypes 21
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:388803 Mathias NA, et al., Loss of the endoplasmic reticulum protein canopy 1 disrupts the function and circuit organization of V2R-expressing vomeronasal sensory neurons. Development. 2026 Jun 15;153(12):dev205386

TSS for Kirrel3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84316	Chr9:34400017-34400041 (+)	2,839 bp
Tssr84317	Chr9:34400083-34400103 (+)	2,903 bp
Tssr84318	Chr9:34400117-34400131 (+)	2,934 bp
Tssr84319	Chr9:34457614-34457617 (+)	60,426 bp
Tssr84320	Chr9:34547599-34547604 (+)	150,412 bp
Tssr84321	Chr9:34558859-34558867 (+)	161,673 bp
Tssr84322	Chr9:34598090-34598095 (+)	200,903 bp
Tssr84323	Chr9:34709098-34709102 (+)	311,910 bp
Tssr2821	Chr9:34911737-34911742 (+)	514,550 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24