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Samsn1 Gene Detail
Summary
  • Symbol
    Samsn1
  • Name
    SAM domain, SH3 domain and nuclear localization signals, 1
  • Synonyms
    4930571B16Rik, Hacs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914992
    NCBI Gene: 67742
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:75655682-75706154 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 43.36 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1936 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914992
 protein coding gene Chr16:75655681-75819169 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022955
 protein coding gene Chr16:75889469-76065003 (-)
A/J MGP_AJ_G0022923
 protein coding gene Chr16:72542168-72699434 (-)
AKR/J MGP_AKRJ_G0022893
 protein coding gene Chr16:74767218-74931816 (-)
BALB/cJ MGP_BALBcJ_G0022925
 protein coding gene Chr16:72937181-73091912 (-)
C3H/HeJ MGP_C3HHeJ_G0022687
 protein coding gene Chr16:75213361-75375483 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023373
 protein coding gene Chr16:78340452-78536413 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020876
 protein coding gene Chr16:71101351-71252749 (-)
CAST/EiJ MGP_CASTEiJ_G0022210
 protein coding gene Chr16:75611389-75770068 (-)
CBA/J MGP_CBAJ_G0022657
 protein coding gene Chr16:81686680-81872663 (-)
DBA/2J MGP_DBA2J_G0022790
 protein coding gene Chr16:72376577-72556736 (-)
FVB/NJ MGP_FVBNJ_G0022765
 protein coding gene Chr16:71773364-71926689 (-)
LP/J MGP_LPJ_G0022860
 protein coding gene Chr16:75675608-75840419 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022783
 protein coding gene Chr16:84788492-84988230 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023390
 protein coding gene Chr16:75092364-75260080 (-)
PWK/PhJ MGP_PWKPhJ_G0021952
 protein coding gene Chr16:72637878-72791844 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021782
 protein coding gene Chr16:74715635-74872553 (-)
WSB/EiJ MGP_WSBEiJ_G0022257
 protein coding gene Chr16:75270561-75443433 (-)



Homology
more
  • Human Ortholog
    SAMSN1, SAM domain, SH3 domain and nuclear localization signals 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SAMSN1, SAM domain, SH3 domain and nuclear localization signals 1
  • Synonyms
    HACS1, NASH1, SASH2, SH3D6B, SLy2
  • Links
    NCBI Gene ID: 64092
    neXtProt AC: NX_Q9NSI8
    UniProt: Q9NSI8

  • Chr Location
    21q11.2; chr21:14485228-14659417 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit enhanced adaptive immunity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    789
  • Tissues
    83
  • cDNA Data
    65
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67742 NCBI Gene Model | MGI Sequence Detail 50473 C57BL/6J ±  kb
    transcript NM_023380 RefSeq | MGI Sequence Detail 1845 C57BL/6  
    polypeptide P57725 UniProt | EBI | MGI Sequence Detail 372 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 67
      Primer pair 2
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:335294 Redhead Y, et al., Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes. Development. 2023 Apr 15;150(8):dev201077
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory