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Eqtn Gene Detail
Summary
  • Symbol
    Eqtn
  • Name
    equatorin, sperm acrosome associated
  • Synonyms
    1700028B15Rik, 4930579C15Rik, Afaf, equatorin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915003
    NCBI Gene: 67753
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:94795504-94817080 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 43.34 cM, cytoband C5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    505 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915003
 protein coding gene Chr4:94763930-94818189 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028454
 protein coding gene Chr4:94956330-94972528 (-)
A/J MGP_AJ_G0028417
 protein coding gene Chr4:91632303-91647217 (-)
AKR/J MGP_AKRJ_G0028364
 protein coding gene Chr4:93826345-93841972 (-)
BALB/cJ MGP_BALBcJ_G0028435
 protein coding gene Chr4:91876875-91891397 (-)
C3H/HeJ MGP_C3HHeJ_G0028148
 protein coding gene Chr4:94646028-94660731 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028874
 protein coding gene Chr4:98605709-98626766 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026168
 protein coding gene Chr4:87140579-87154354 (-)
CAST/EiJ MGP_CASTEiJ_G0027588
 protein coding gene Chr4:92507504-92523508 (-)
CBA/J MGP_CBAJ_G0028117
 protein coding gene Chr4:101599126-101617835 (-)
DBA/2J MGP_DBA2J_G0028267
 protein coding gene Chr4:91420328-91439940 (-)
FVB/NJ MGP_FVBNJ_G0028234
 protein coding gene Chr4:90287224-90308974 (-)
LP/J MGP_LPJ_G0028367
 protein coding gene Chr4:95275281-95290837 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028262
 protein coding gene Chr4:107367069-107389104 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028912
 protein coding gene Chr4:94107144-94127210 (-)
PWK/PhJ MGP_PWKPhJ_G0027313
 protein coding gene Chr4:89570426-89585337 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027134
 protein coding gene Chr4:91522934-91537839 (-)
WSB/EiJ MGP_WSBEiJ_G0027666
 protein coding gene Chr4:94257548-94272570 (-)



Homology
more
  • Human Ortholog
    EQTN, equatorin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EQTN, equatorin
  • Synonyms
    AFAF, C9orf11, SPACA8
  • Links
    NCBI Gene ID: 54586
    neXtProt AC: NX_Q9NQ60
    UniProt: Q9NQ60

  • Chr Location
    9p21.2; chr9:27284654-27297150 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced male fertility, oligozoospermia, and severely decreased fertilization and induced acrosome reaction rates.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028575 Ensembl Gene Model | MGI Sequence Detail 21577 C57BL/6J ±  kb
    transcript ENSMUST00000030309 Ensembl | MGI Sequence Detail 1074 Not Applicable  
    polypeptide ENSMUSP00000030309 Ensembl | MGI Sequence Detail 337 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 1
      cDNA 7

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1916718, MGI:2140689
    References
    more
    • Summaries
      All 34
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:177032 Toshimori K, et al., An MN9 antigenic molecule, equatorin, is required for successful sperm-oocyte fusion in mice. Biol Reprod. 1998 Jul;59(1):22-9
    • Latest
      J:285739 Ito C, et al., Deletion of Eqtn in mice reduces male fertility and sperm-egg adhesion. Reproduction. 2018 Dec;156(6):579-590
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory