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Ddx47 Gene Detail
Summary
  • Symbol
    Ddx47
  • Name
    DEAD box helicase 47
  • Synonyms
    4930588A18Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915005
    NCBI Gene: 67755
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:134988575-135000739 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 65.77 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    515 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915005
 protein coding gene Chr6:134988575-135000739 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031412
 protein coding gene Chr6:139327097-139340798 (+)
A/J MGP_AJ_G0031388
 protein coding gene Chr6:133843943-133856049 (+)
AKR/J MGP_AKRJ_G0031315
 protein coding gene Chr6:137904262-137920297 (+)
BALB/cJ MGP_BALBcJ_G0031394
 protein coding gene Chr6:133660482-133673022 (+)
C3H/HeJ MGP_C3HHeJ_G0031116
 protein coding gene Chr6:137951199-137963183 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031854
 protein coding gene Chr6:143103351-143116822 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028986
 protein coding gene Chr6:132988850-133000755 (+)
CAST/EiJ MGP_CASTEiJ_G0030485
 protein coding gene Chr6:137374502-137387733 (+)
CBA/J MGP_CBAJ_G0031075
 protein coding gene Chr6:148444538-148459322 (+)
DBA/2J MGP_DBA2J_G0031233
 protein coding gene Chr6:132695666-132707571 (+)
FVB/NJ MGP_FVBNJ_G0031183
 protein coding gene Chr6:131608053-131619871 (+)
LP/J MGP_LPJ_G0031317
 protein coding gene Chr6:139423080-139436618 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031223
 protein coding gene Chr6:152485548-152497496 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031887
 protein coding gene Chr6:137648979-137661132 (+)
PWK/PhJ MGP_PWKPhJ_G0030210
 protein coding gene Chr6:131187624-131199783 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030034
 protein coding gene Chr6:135831460-135842993 (+)
WSB/EiJ MGP_WSBEiJ_G0030576
 protein coding gene Chr6:138289888-138304980 (+)



Homology
more
  • Human Ortholog
    DDX47, DEAD-box helicase 47
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDX47, DEAD-box helicase 47
  • Synonyms
    E4-DBP, HQ0256, MSTP162, RRP3
  • Links
    NCBI Gene ID: 51202
    neXtProt AC: NX_Q9H0S4
    UniProt: Q9H0S4

  • Chr Location
    12p13.1; chr12:12813316-12829981 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro outgrowth assays show that blastocysts hatch from the zona pellucida but form irregular outgrowths.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    21
  • cDNA Data
    136
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67755 NCBI Gene Model | MGI Sequence Detail 12165 C57BL/6J ±  kb
transcript NM_026360 RefSeq | MGI Sequence Detail 1764 C57BL/6  
polypeptide Q9CWX9 UniProt | EBI | MGI Sequence Detail 455 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 136
    cDNA 136

    Microarray probesets 5
Other
Accession IDs
less
MGI:2141744
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory