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Plgrkt Gene Detail
Summary
  • Symbol
    Plgrkt
  • Name
    plasminogen receptor, C-terminal lysine transmembrane protein
  • Synonyms
    1110007H22Rik, 5033414D02Rik, Plg-RKT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915009
    NCBI Gene: 67759
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:29326004-29339340 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 23.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    496 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915009
 protein coding gene Chr19:29325999-29344790 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025021
 protein coding gene Chr19:27801383-27821714 (-)
A/J MGP_AJ_G0024998
 protein coding gene Chr19:26400711-26420188 (-)
AKR/J MGP_AKRJ_G0024966
 protein coding gene Chr19:27358337-27378638 (-)
BALB/cJ MGP_BALBcJ_G0024997
 protein coding gene Chr19:26450458-26469628 (-)
C3H/HeJ MGP_C3HHeJ_G0024753
 protein coding gene Chr19:27334094-27355045 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025438
 protein coding gene Chr19:28575066-28595228 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022857
 protein coding gene Chr19:26373005-26392062 (-)
CAST/EiJ MGP_CASTEiJ_G0024223
 protein coding gene Chr19:27160327-27183921 (-)
CBA/J MGP_CBAJ_G0024731
 protein coding gene Chr19:29924780-29943555 (-)
DBA/2J MGP_DBA2J_G0024863
 protein coding gene Chr19:26359302-26378062 (-)
FVB/NJ MGP_FVBNJ_G0024825
 protein coding gene Chr19:26215849-26235017 (-)
LP/J MGP_LPJ_G0024948
 protein coding gene Chr19:27804193-27824632 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024852
 protein coding gene Chr19:29866477-29884951 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025493
 protein coding gene Chr19:27378123-27396863 (-)
PWK/PhJ MGP_PWKPhJ_G0023971
 protein coding gene Chr19:26032546-26051528 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023775
 protein coding gene Chr19:26649659-26671727 (-)
WSB/EiJ MGP_WSBEiJ_G0024290
 protein coding gene Chr19:27426857-27445616 (-)



Homology
more
  • Human Ortholog
    PLGRKT, plasminogen receptor with a C-terminal lysine
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLGRKT, plasminogen receptor with a C-terminal lysine
  • Synonyms
    AD025, C9orf46, MDS030, Plg-R(KT), PLG-RKT
  • Links
    NCBI Gene ID: 55848
    neXtProt AC: NX_Q9HBL7
    UniProt: Q9HBL7

  • Chr Location
    9p24.1; chr9:5357971-5438377 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced female body weight, reduced milk production leading to pup lethality, dermatitis, and reduced leukocyte recruitment. Heterozygotes exhibit an intermediate dermatitis phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    1
  • cDNA Data
    48
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67759 NCBI Gene Model | MGI Sequence Detail 13337 C57BL/6J ±  kb
    transcript NM_026362 RefSeq | MGI Sequence Detail 843 C57BL/6  
    polypeptide Q9D3P8 UniProt | EBI | MGI Sequence Detail 147 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      cDNA 48

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1921089, MGI:2147620
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:348802 Miles LA, et al., Overexpression of Plg-R(KT) protects against adipose dysfunction and dysregulation of glucose homeostasis in diet-induced obese mice. Adipocyte. 2023 Dec;12(1):2252729
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory