N6amt1 MGI Mouse Gene Detail - MGI:1915018 - N-6 adenine-specific DNA methyltransferase 1 (putative)

Symbol

N6amt1
Name

N-6 adenine-specific DNA methyltransferase 1 (putative)
Synonyms

5830445C04Rik, Hemk2, Pred28

Feature Type

protein coding gene
IDs

MGI:1915018
NCBI Gene: 67768
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr16:87151073-87165537 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 49.52 cM, cytoband C3.3
Mapping Data

2 experiments

SNPs within 2kb

702 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915018	protein coding gene	Chr16:87151073-87165630 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022975	protein coding gene	Chr16:88065882-88080333 (+)
A/J	MGP_AJ_G0022943	protein coding gene	Chr16:84009841-84023040 (+)
AKR/J	MGP_AKRJ_G0022913	protein coding gene	Chr16:86554068-86567311 (+)
BALB/cJ	MGP_BALBcJ_G0022945	protein coding gene	Chr16:84526057-84548314 (+)
C3H/HeJ	MGP_C3HHeJ_G0022707	protein coding gene	Chr16:87118988-87132932 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023392	protein coding gene	Chr16:90922749-90940656 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020896	protein coding gene	Chr16:81864896-81877433 (+)
CAST/EiJ	MGP_CASTEiJ_G0022229	protein coding gene	Chr16:87501037-87516351 (+)
CBA/J	MGP_CBAJ_G0022676	protein coding gene	Chr16:94819019-94842574 (+)
DBA/2J	MGP_DBA2J_G0022810	protein coding gene	Chr16:83931536-83946367 (+)
FVB/NJ	MGP_FVBNJ_G0022785	protein coding gene	Chr16:83035383-83048323 (+)
LP/J	MGP_LPJ_G0022879	protein coding gene	Chr16:87758320-87772325 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022804	protein coding gene	Chr16:99383310-99399866 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023410	protein coding gene	Chr16:87020242-87034506 (+)
PWK/PhJ	MGP_PWKPhJ_G0021971	protein coding gene	Chr16:84035297-84048191 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021802	protein coding gene	Chr16:86553141-86568067 (+)
WSB/EiJ	MGP_WSBEiJ_G0022277	protein coding gene	Chr16:87263156-87278411 (+)

Human Ortholog

N6AMT1, N-6 adenine-specific DNA methyltransferase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

N6AMT1, N-6 adenine-specific DNA methyltransferase 1
Synonyms

C21orf127, HEMK2, KMT9, m.HsaHemK2P, MTQ2, N6AMT, PRED28, PrmC
Links

HGNC:16021

NCBI Gene ID: 29104

neXtProt AC: NX_Q9Y5N5

UniProt: Q9Y5N5
Chr Location

21q21.3; chr21:28575598-28885371 (-) GRCh38

MGI Vertebrate Homology

N6amt1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: N6AMT1
Gene Tree

N6amt1

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Gene trapped

1
Targeted

6
Genomic Mutations

3 involving N6amt1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele fail to form a primitive streak and die between E7.5 and E9.5.

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All GO Annotations

31
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

772
Tissues

65
cDNA Data

15
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase n6amt1

ZFIN n6amt1

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All Sequences

49
RefSeq

4
UniProt

3
CCDS

CCDS28289.1, CCDS49889.1

Ensembl

ENSMUSG00000044442 (Evidence)
NCBI Gene

67768

			Length	Strain/Species	Flank
genomic	67768	NCBI Gene Model \| MGI Sequence Detail	14465	C57BL/6J	± kb
transcript	NM_026366	RefSeq \| MGI Sequence Detail	1791	Not Specified
polypeptide	Q6SKR2	UniProt \| EBI \| MGI Sequence Detail	214	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010942 methyltransferase N6AMT1

(term hierarchy)
EC

2.1.1.-
InterPro Domains

IPR002052 DNA methylase, N-6 adenine-specific, conserved site

IPR004557 Eukaryotic/archaeal PrmC-related

IPR052190 Eukaryotic/Archaeal PrmC-Related Methyltransferase

IPR007848 Methyltransferase small domain

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

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All nucleic 18

cDNA 15

Primer pair 2

Other 1

Microarray probesets 6

Summaries

All 41

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:335294 Redhead Y, et al., Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes. Development. 2023 Apr 15;150(8):dev201077

TSS for N6amt1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139217	Chr16:87151092-87151137 (+)	42 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24