Dgat2 MGI Mouse Gene Detail - MGI:1915050 - diacylglycerol O-acyltransferase 2

Symbol

Dgat2
Name

diacylglycerol O-acyltransferase 2
Synonyms

0610010B06Rik

Feature Type

protein coding gene
IDs

MGI:1915050
NCBI Gene: 67800
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr7:98802870-98831920 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.01 cM, cytoband F1
Mapping Data

2 experiments

SNPs within 2kb

881 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915050	protein coding gene	Chr7:98802865-98831926 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032545	protein coding gene	Chr7:101926255-101956614 (-)
A/J	MGP_AJ_G0032519	protein coding gene	Chr7:99398252-99426945 (-)
AKR/J	MGP_AKRJ_G0032455	protein coding gene	Chr7:101758919-101789032 (-)
BALB/cJ	MGP_BALBcJ_G0032530	protein coding gene	Chr7:99087312-99116398 (-)
C3H/HeJ	MGP_C3HHeJ_G0032245	protein coding gene	Chr7:102115371-102144047 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033028	protein coding gene	Chr7:105847849-105876501 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030023	protein coding gene	Chr7:101835929-101864869 (-)
CAST/EiJ	MGP_CASTEiJ_G0031572	protein coding gene	Chr7:93651657-93681538 (-)
CBA/J	MGP_CBAJ_G0032212	protein coding gene	Chr7:109473823-109502494 (-)
DBA/2J	MGP_DBA2J_G0032364	protein coding gene	Chr7:97738424-97767109 (-)
FVB/NJ	MGP_FVBNJ_G0032321	protein coding gene	Chr7:97528648-97558139 (-)
LP/J	MGP_LPJ_G0032453	protein coding gene	Chr7:103248552-103285177 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032353	protein coding gene	Chr7:110946384-110976902 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033050	protein coding gene	Chr7:101027939-101057502 (-)
PWK/PhJ	MGP_PWKPhJ_G0031290	protein coding gene	Chr7:90825440-90854872 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031133	protein coding gene	Chr7:88325618-88355530 (-)
WSB/EiJ	MGP_WSBEiJ_G0031689	protein coding gene	Chr7:101699250-101727867 (-)

Human Ortholog

DGAT2, diacylglycerol O-acyltransferase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DGAT2, diacylglycerol O-acyltransferase 2
Synonyms

ARAT, GS1999FULL, HMFN1045
Links

HGNC:16940

NCBI Gene ID: 84649

neXtProt AC: NX_Q96PD7

UniProt: Q96PD7
Chr Location

11q13.5; chr11:75759512-75801535 (+) GRCh38

MGI Vertebrate Homology

Dgat2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DGAT2
Gene Tree

Dgat2

Diseases

1 with human DGAT2 associations

				Human Disease	Mouse Models
				metabolic dysfunction-associated steatotic liver disease IDs metabolic dysfunction-associated steatotic liver disease DOID:0080208 MESH:D065626 OMIM:613282 OMIM:613387

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

30 phenotypes from 2 alleles in 2 genetic backgrounds
3 images
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Dgat2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice die shortly after birth due to inadequate substrates for energy and impaired skin barrier function leading to dehydration.

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All GO Annotations

58
GO References

20

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

883
Tissues

120
cDNA Data

6
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dgat2

ZFIN dgat2

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All Sequences

41
RefSeq

2
UniProt

4
CCDS

CCDS21477.1

Ensembl

ENSMUSG00000030747 (Evidence)
NCBI Gene

67800

			Length	Strain/Species	Flank
genomic	67800	NCBI Gene Model \| MGI Sequence Detail	29051	C57BL/6J	± kb
transcript	NM_026384	RefSeq \| MGI Sequence Detail	2251	C57BL/6
polypeptide	Q9DCV3	UniProt \| EBI \| MGI Sequence Detail	388	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006433 diacylglycerol O-acyltransferase 2

(term hierarchy)
EC

2.3.1.20, 2.3.1.76
InterPro Domains

IPR007130 Diacylglycerol acyltransferase

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All nucleic 13

cDNA 6

Primer pair 7

Microarray probesets 3

Summaries

All 89

Developmental Gene Expression 16

Gene Ontology 20

Phenotypes 22
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:348785 Zhang D, et al., Maternal Ezh1/2 deficiency impairs the function of mitochondria in mouse oocytes and early embryos. J Cell Physiol. 2024 Mar 26;

TSS for Dgat2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr73670	Chr7:98833047-98833067 (-)	-1,137 bp
Tssr73669	Chr7:98831942-98831953 (-)	-28 bp
Tssr73668	Chr7:98831888-98831935 (-)	8 bp
Tssr73667	Chr7:98831862-98831873 (-)	52 bp
Tssr73666	Chr7:98829472-98829526 (-)	2,421 bp
Tssr73665	Chr7:98819248-98819252 (-)	12,670 bp
Tssr73664	Chr7:98819021-98819043 (-)	12,888 bp
Tssr73663	Chr7:98813868-98813899 (-)	18,036 bp
Tssr73662	Chr7:98811426-98811430 (-)	20,492 bp
Tssr73661	Chr7:98808255-98808269 (-)	23,658 bp
Tssr73660	Chr7:98806258-98806285 (-)	25,648 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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