Derl1 MGI Mouse Gene Detail - MGI:1915069 - Der1-like domain family, member 1

Symbol

Derl1
Name

Der1-like domain family, member 1
Synonyms

1110021N07Rik, Derlin-1

Feature Type

protein coding gene
IDs

MGI:1915069
NCBI Gene: 67819
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr15:57732898-57755814 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 24.06 cM, cytoband D2
Mapping Data

3 experiments

SNPs within 2kb

658 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915069	protein coding gene	Chr15:57732898-57755844 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021862	protein coding gene	Chr15:57021286-57044800 (-)
A/J	MGP_AJ_G0021822	protein coding gene	Chr15:54782395-54805537 (-)
AKR/J	MGP_AKRJ_G0021803	protein coding gene	Chr15:56276358-56299323 (-)
BALB/cJ	MGP_BALBcJ_G0021829	protein coding gene	Chr15:55012090-55032964 (-)
C3H/HeJ	MGP_C3HHeJ_G0021603	protein coding gene	Chr15:56424782-56447070 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022268	protein coding gene	Chr15:59243588-59269426 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019805	protein coding gene	Chr15:51876722-51899708 (-)
CAST/EiJ	MGP_CASTEiJ_G0021120	protein coding gene	Chr15:57049355-57071267 (-)
CBA/J	MGP_CBAJ_G0021572	protein coding gene	Chr15:61302733-61326042 (-)
DBA/2J	MGP_DBA2J_G0021696	protein coding gene	Chr15:54707131-54729183 (-)
FVB/NJ	MGP_FVBNJ_G0021674	protein coding gene	Chr15:53760506-53781363 (-)
LP/J	MGP_LPJ_G0021766	protein coding gene	Chr15:56869065-56889887 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021698	protein coding gene	Chr15:66391048-66411599 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022291	protein coding gene	Chr15:56714417-56738541 (-)
PWK/PhJ	MGP_PWKPhJ_G0020865	protein coding gene	Chr15:54710032-54731265 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020702	protein coding gene	Chr15:56480127-56503125 (-)
WSB/EiJ	MGP_WSBEiJ_G0021175	protein coding gene	Chr15:56688560-56711971 (-)

Human Ortholog

DERL1, derlin 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DERL1, derlin 1
Synonyms

DER-1, DER1, derlin-1
Links

HGNC:28454

NCBI Gene ID: 79139

neXtProt AC: NX_Q9BUN8

UniProt: Q9BUN8
Chr Location

8q24.13; chr8:123013170-123042302 (-) GRCh38

MGI Vertebrate Homology

Derl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DERL1
Gene Tree

Derl1

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
1 images
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

3
Endonuclease-mediated

1
Gene trapped

2
Radiation induced

1
Targeted

2
Genomic Mutations

4 involving Derl1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

12 strains or lines available

Mice homozygous for a knock-out allele exhibit lethality during embryogenesis.

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All GO Annotations

48
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

8
cDNA Data

18
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase derl1

ZFIN derl1

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All Sequences

68
RefSeq

2
UniProt

2
CCDS

CCDS27484.1

Ensembl

ENSMUSG00000022365 (Evidence)
NCBI Gene

67819

			Length	Strain/Species	Flank
genomic	67819	NCBI Gene Model \| MGI Sequence Detail	22917	C57BL/6J	± kb
transcript	NM_024207	RefSeq \| MGI Sequence Detail	3145	C57BL/6
polypeptide	Q99J56	UniProt \| EBI \| MGI Sequence Detail	251	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006422 derlin-1

(term hierarchy)
InterPro Domains

IPR007599 Derlin

IPR035952 Rhomboid-like superfamily

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All nucleic 19

cDNA 18

Primer pair 1

Microarray probesets 6

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MGI:2145956, MGI:2146235

Summaries

All 54

Developmental Gene Expression 3

Diseases 1

Gene Ontology 10

Phenotypes 16
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:311891 Sugiyama T, et al., ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function. iScience. 2021 Jul 23;24(7):102758

TSS for Derl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134372	Chr15:57755754-57755879 (-)	-3 bp
Tssr134371	Chr15:57755732-57755743 (-)	76 bp
Tssr134370	Chr15:57755708-57755719 (-)	100 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24