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Rgs10 Gene Detail
Summary
  • Symbol
    Rgs10
  • Name
    regulator of G-protein signalling 10
  • Synonyms
    2310010N19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915115
    NCBI Gene: 67865
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127975345-128020482 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 70.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1027 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915115
 protein coding gene Chr7:127975345-128020993 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033082
 protein coding gene Chr7:132795812-132847419 (-)
A/J MGP_AJ_G0033064
 protein coding gene Chr7:129226529-129271099 (-)
AKR/J MGP_AKRJ_G0032996
 protein coding gene Chr7:132619405-132664861 (-)
BALB/cJ MGP_BALBcJ_G0033065
 protein coding gene Chr7:128893171-128938224 (-)
C3H/HeJ MGP_C3HHeJ_G0032779
 protein coding gene Chr7:132493181-132539742 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033575
 protein coding gene Chr7:137983127-138030455 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030547
 protein coding gene Chr7:130402323-130444560 (-)
CAST/EiJ MGP_CASTEiJ_G0032109
 protein coding gene Chr7:124277999-124329964 (-)
CBA/J MGP_CBAJ_G0032752
 protein coding gene Chr7:142695582-142755082 (-)
DBA/2J MGP_DBA2J_G0032904
 protein coding gene Chr7:127210946-127255779 (-)
FVB/NJ MGP_FVBNJ_G0032857
 protein coding gene Chr7:127080198-127125091 (-)
LP/J MGP_LPJ_G0032998
 protein coding gene Chr7:134276048-134319737 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032889
 protein coding gene Chr7:143710792-143760944 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033594
 protein coding gene Chr7:131570934-131618777 (-)
PWK/PhJ MGP_PWKPhJ_G0031815
 protein coding gene Chr7:120225959-120277058 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031661
 protein coding gene Chr7:118379225-118427827 (-)
WSB/EiJ MGP_WSBEiJ_G0032220
 protein coding gene Chr7:132545318-132594674 (-)



Homology
more
  • Human Ortholog
    RGS10, regulator of G protein signaling 10
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RGS10, regulator of G protein signaling 10
  • Links
    NCBI Gene ID: 6001
    neXtProt AC: NX_O43665
    UniProt: O43665

  • Chr Location
    10q26.11; chr10:119499817-119542719 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A gene trap mutation of this gene results in impaired glucose tolerance and increased fasting glucose levels whereas a targeted knockout shows defects in osteoclast differentiation and in the skeleton.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    18
  • cDNA Data
    40
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030844 Ensembl Gene Model | MGI Sequence Detail 45138 C57BL/6J ±  kb
    transcript ENSMUST00000033133 Ensembl | MGI Sequence Detail 880 Not Applicable  
    polypeptide ENSMUSP00000033133 Ensembl | MGI Sequence Detail 181 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 40
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:331204 Almutairi F, et al., RGS10 Reduces Lethal Influenza Infection and Associated Lung Inflammation in Mice. Front Immunol. 2021;12:772288
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory