Cela3b Gene Detail

Summary

• Symbol
  Cela3b
• Name
  chymotrypsin-like elastase family, member 3B
• Synonyms
  0910001F22Rik, 2310074F01Rik, Ela3, Ela3b

• Feature Type
  protein coding gene
• IDs
  MGI:1915118
  NCBI Gene: 67868
• Alliance
  gene page
• Transcription Start Sites
  1 TSS
• Candidate for QTL
  5 QTL

Location &
Maps

• Sequence Map
  Chr4:137148319-137157831 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 4, 69.90 cM
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  678 from dbSNP Build 142
• Strain Annotations
  16

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915118	protein coding gene	Chr4:137148310-137157851 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028981	protein coding gene	Chr4:140045985-140055914 (-)
A/J	MGP_AJ_G0028940	protein coding gene	Chr4:134093460-134107289 (-)
AKR/J	MGP_AKRJ_G0028892	protein coding gene	Chr4:137948185-137957839 (-)
BALB/cJ	MGP_BALBcJ_G0028964	protein coding gene	Chr4:134777316-134785888 (-)
C3H/HeJ	MGP_C3HHeJ_G0028678	protein coding gene	Chr4:138247581-138264256 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029405	protein coding gene	Chr4:144999784-145008575 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026676	protein coding gene	Chr4:127100625-127109434 (-)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0028643	protein coding gene	Chr4:149093899-149106732 (-)
DBA/2J	MGP_DBA2J_G0028792	protein coding gene	Chr4:134492147-134499665 (-)
FVB/NJ	MGP_FVBNJ_G0028759	protein coding gene	Chr4:133453893-133491907 (-)
LP/J	MGP_LPJ_G0028891	protein coding gene	Chr4:140101049-140140181 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028785	protein coding gene	Chr4:153161312-153175833 (-)
NZO/HlLtJ	no annotation
PWK/PhJ	MGP_PWKPhJ_G0027830	protein coding gene	Chr4:131313140-131321019 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027656	protein coding gene	Chr4:134199890-134208160 (-)
WSB/EiJ	MGP_WSBEiJ_G0028188	protein coding gene	Chr4:138585239-138595782 (-)

Homology

• Human Ortholog
  CELA3A, chymotrypsin like elastase 3A

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  CELA3A, chymotrypsin like elastase 3A
  
• Synonyms
  ELA3, ELA3A
• Links
  HGNC:15944

  NCBI Gene ID: 10136

  neXtProt AC: NX_P09093

  UniProt: P09093

  
  
• Chr Location
  1p36.12; chr1:22001657-22012542 (+)  GRCh38

---

• Human Ortholog
  CELA3B, chymotrypsin like elastase 3B
  
• Synonyms
  CBPP, ELA3B
• Links
  HGNC:15945

  NCBI Gene ID: 23436

  neXtProt AC: NX_P08861

  UniProt: P08861

  
  
• Chr Location
  1p36.12; chr1:21977022-21998642 (+)  GRCh38

---

• MGI Vertebrate Homology
  Cela3b stringent orthology
  2 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: CELA3A, CELA3B
• Gene Tree
  Cela3b
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotype references
  

• All Mutations and Alleles
  6
• Chemically induced (other)
  2
• Endonuclease-mediated
  1
• Gene trapped
  1
• Targeted
  2
• Genomic Mutations
  3 involving Cela3b
• Incidental Mutations
  APF
• Find Mice (IMSR)
  13 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  6
• GO References
  4

Expression

• Assay Results
  712
• Tissues
  3
• cDNA Data
  318
• Literature Summary
  7

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase cela3b

Sequences &
Gene Models

• All Sequences
  32
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS18817.1

• Ensembl
  ENSMUSG00000023433 (Evidence)
• NCBI Gene
  67868

Representative Sequences			Length	Strain/Species
genomic	67868	NCBI Gene Model | MGI Sequence Detail	9513	C57BL/6J
transcript	NM_026419	RefSeq | MGI Sequence Detail	897	ZRU/MplStud
polypeptide	Q9CQ52	UniProt | EBI | MGI Sequence Detail	269	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• EC
  3.4.21.70
• InterPro Domains
  IPR001314 Peptidase S1A, chymotrypsin family
  IPR050850 Peptidase S1 family, Elastase subfamily
  IPR009003 Peptidase S1, PA clan
  IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
  IPR001254 Serine proteases, trypsin domain
  IPR018114 Serine proteases, trypsin family, histidine active site
  IPR033116 Serine proteases, trypsin family, serine active site

Molecular
Reagents

• All nucleic 320

  cDNA 319

  Other 1

  
  

  Microarray probesets 5

Other
Accession IDs

MGI:1923522, MGI:2140315

References

• Summaries
  All 39

  Developmental Gene Expression 7

  Gene Ontology 4

  Phenotypes 8
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:337474 Cobo I, et al., NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation. Nat Commun. 2023 Jun 23;14(1):3761

TSS for Cela3b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr44125	Chr4:137157828-137157836 (-)	-1 bp

Cela3b is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Bglq4	Chr4, 33.96 cM		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Tafat (80 cM) on mouse Chromosome 4 as identified by ExQuest are Ela2, Ela3b, and Dvl1 (82 cM). Chr 10 locus Ela2 exhibits 55-fold decreased expression in the pancreas of Tally Ho animals compared to C57BL/6J. For QTL Bwq1 (6.3 cM), potential candidate gene Decr1 was identified. For QTLs Triglq1 (6.5 cM) and Bglq4 (6.5 cM), potential candidate genes Ttpa, Bhmt(Chr 13), Baat(22.7 cM), and Aldob (22.3 cM) were identified. For QTLs Nidd1 (48 cM) and Dob1 (50 cM), potential candidate genes Lepr (46.7 cM), Dio1 (48.7 cM), Scp2 (52 cM), Faah (56.5 cM), and Usp1 were identified.
Dob1	Chr4, syntenic	Chr4:101574601-123127211	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Tafat (80 cM) on mouse Chromosome 4 as identified by ExQuest are Ela2, Ela3b, and Dvl1 (82 cM). Chr 10 locus Ela2 exhibits 55-fold decreased expression in the pancreas of Tally Ho animals compared to C57BL/6J. For QTL Bwq1 (6.3 cM), potential candidate gene Decr1 was identified. For QTLs Triglq1 (6.5 cM) and Bglq4 (6.5 cM), potential candidate genes Ttpa, Bhmt(Chr 13), Baat(22.7 cM), and Aldob (22.3 cM) were identified. For QTLs Nidd1 (48 cM) and Dob1 (50 cM), potential candidate genes Lepr (46.7 cM), Dio1 (48.7 cM), Scp2 (52 cM), Faah (56.5 cM), and Usp1 were identified.
Nidd1	Chr4, syntenic		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Tafat (80 cM) on mouse Chromosome 4 as identified by ExQuest are Ela2, Ela3b, and Dvl1 (82 cM). Chr 10 locus Ela2 exhibits 55-fold decreased expression in the pancreas of Tally Ho animals compared to C57BL/6J. For QTL Bwq1 (6.3 cM), potential candidate gene Decr1 was identified. For QTLs Triglq1 (6.5 cM) and Bglq4 (6.5 cM), potential candidate genes Ttpa, Bhmt(Chr 13), Baat(22.7 cM), and Aldob (22.3 cM) were identified. For QTLs Nidd1 (48 cM) and Dob1 (50 cM), potential candidate genes Lepr (46.7 cM), Dio1 (48.7 cM), Scp2 (52 cM), Faah (56.5 cM), and Usp1 were identified.
Tafat	Chr4, 74.75 cM	Chr4:141621281-141621387	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Tafat (80 cM) on mouse Chromosome 4 as identified by ExQuest are Ela2, Ela3b, and Dvl1 (82 cM). Chr 10 locus Ela2 exhibits 55-fold decreased expression in the pancreas of Tally Ho animals compared to C57BL/6J. For QTL Bwq1 (6.3 cM), potential candidate gene Decr1 was identified. For QTLs Triglq1 (6.5 cM) and Bglq4 (6.5 cM), potential candidate genes Ttpa, Bhmt(Chr 13), Baat(22.7 cM), and Aldob (22.3 cM) were identified. For QTLs Nidd1 (48 cM) and Dob1 (50 cM), potential candidate genes Lepr (46.7 cM), Dio1 (48.7 cM), Scp2 (52 cM), Faah (56.5 cM), and Usp1 were identified.
Triglq1	Chr4, 10.61 cM	Chr4:25683240-25683429	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Tafat (80 cM) on mouse Chromosome 4 as identified by ExQuest are Ela2, Ela3b, and Dvl1 (82 cM). Chr 10 locus Ela2 exhibits 55-fold decreased expression in the pancreas of Tally Ho animals compared to C57BL/6J. For QTL Bwq1 (6.3 cM), potential candidate gene Decr1 was identified. For QTLs Triglq1 (6.5 cM) and Bglq4 (6.5 cM), potential candidate genes Ttpa, Bhmt(Chr 13), Baat(22.7 cM), and Aldob (22.3 cM) were identified. For QTLs Nidd1 (48 cM) and Dob1 (50 cM), potential candidate genes Lepr (46.7 cM), Dio1 (48.7 cM), Scp2 (52 cM), Faah (56.5 cM), and Usp1 were identified.

*cM position of peak correlated region/marker