About   Help   FAQ
Rprm Gene Detail
Summary
  • Symbol
    Rprm
  • Name
    reprimo, TP53 dependent G2 arrest mediator candidate
  • Synonyms
    2410012A13Rik, Reprimo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915124
    NCBI Gene: 67874
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr2:53974105-53975564 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 30.69 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915124
 protein coding gene Chr2:53974105-53975564 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025740
 protein coding gene Chr2:53488668-53490127 (-)
A/J MGP_AJ_G0025716
 protein coding gene Chr2:51407552-51409011 (-)
AKR/J MGP_AKRJ_G0025686
 protein coding gene Chr2:52874639-52876098 (-)
BALB/cJ MGP_BALBcJ_G0025711
 protein coding gene Chr2:51510519-51511978 (-)
C3H/HeJ MGP_C3HHeJ_G0025472
 protein coding gene Chr2:52911373-52912832 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026157
 protein coding gene Chr2:55069919-55071378 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023563
 protein coding gene Chr2:49266464-49267928 (-)
CAST/EiJ MGP_CASTEiJ_G0024937
 protein coding gene Chr2:52983934-52985394 (-)
CBA/J MGP_CBAJ_G0025452
 protein coding gene Chr2:57130117-57131576 (-)
DBA/2J MGP_DBA2J_G0025583
 protein coding gene Chr2:51035304-51036763 (-)
FVB/NJ MGP_FVBNJ_G0025545
 protein coding gene Chr2:50699755-50701214 (-)
LP/J MGP_LPJ_G0025671
 protein coding gene Chr2:53339290-53340749 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025576
 protein coding gene Chr2:58171217-58172676 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026215
 protein coding gene Chr2:52827016-52828475 (-)
PWK/PhJ MGP_PWKPhJ_G0024678
 protein coding gene Chr2:50892917-50894376 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024484
 protein coding gene Chr2:52991673-52993132 (-)
WSB/EiJ MGP_WSBEiJ_G0025004
 protein coding gene Chr2:53098999-53100458 (-)



Homology
more
  • Human Ortholog
    RPRM, reprimo, TP53 dependent G2 arrest mediator homolog
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPRM, reprimo, TP53 dependent G2 arrest mediator homolog
  • Synonyms
    REPRIMO
  • Links
    NCBI Gene ID: 56475
    neXtProt AC: NX_Q9NS64
    UniProt: Q9NS64

  • Chr Location
    2q23.3; chr2:153477338-153478762 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    962
  • Tissues
    49
  • cDNA Data
    28
  • Literature Summary
    14
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67874 NCBI Gene Model | MGI Sequence Detail 1460 C57BL/6J ±  kb
transcript NM_023396 RefSeq | MGI Sequence Detail 1460 C57BL/6  
polypeptide Q9JJ72 UniProt | EBI | MGI Sequence Detail 109 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    cDNA 28
    Primer pair 2
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 46
    Developmental Gene Expression 14
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:73429 Ohki R, et al., Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase. J Biol Chem. 2000 Jul 28;275(30):22627-30
  • Latest
    J:352165 Lin Y, et al., Denticleless E3 ubiquitin protein ligase (DTL) maintains the proliferation and differentiation of epidermis and hair follicles during skin development. Dev Dyn. 2024 Jul;253(7):635-647
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory