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Dcxr Gene Detail
Summary
  • Symbol
    Dcxr
  • Name
    dicarbonyl L-xylulose reductase
  • Synonyms
    0610038K04Rik, 1810027P18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915130
    NCBI Gene: 67880
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120616225-120618107 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 84.47 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    121 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915130
 protein coding gene Chr11:120615372-120618110 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019525
 protein coding gene Chr11:125210307-125214054 (-)
A/J MGP_AJ_G0019493
 protein coding gene Chr11:119635712-119637375 (-)
AKR/J MGP_AKRJ_G0019463
 protein coding gene Chr11:123252939-123256265 (-)
BALB/cJ MGP_BALBcJ_G0019468
 protein coding gene Chr11:119995269-119997617 (-)
C3H/HeJ MGP_C3HHeJ_G0019274
 protein coding gene Chr11:123583052-123586032 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019916
 protein coding gene Chr11:128996108-128998021 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017542
 protein coding gene Chr11:116626319-116628188 (-)
CAST/EiJ MGP_CASTEiJ_G0018828
 protein coding gene Chr11:125082189-125084081 (-)
CBA/J MGP_CBAJ_G0019245
 protein coding gene Chr11:134032098-134033961 (-)
DBA/2J MGP_DBA2J_G0019357
 protein coding gene Chr11:119003775-119006252 (-)
FVB/NJ MGP_FVBNJ_G0019349
 protein coding gene Chr11:118718282-118720148 (-)
LP/J MGP_LPJ_G0019429
 protein coding gene Chr11:125511820-125513684 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019382
 protein coding gene Chr11:132869404-132873833 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019956
 protein coding gene Chr11:123921965-123923872 (-)
PWK/PhJ MGP_PWKPhJ_G0018594
 protein coding gene Chr11:120448544-120450442 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018386
 protein coding gene Chr11:123691564-123693427 (-)
WSB/EiJ MGP_WSBEiJ_G0018880
 protein coding gene Chr11:123920674-123922550 (-)



Homology
more
  • Human Ortholog
    DCXR, dicarbonyl and L-xylulose reductase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DCXR, dicarbonyl and L-xylulose reductase
  • Synonyms
    DCR, HCR2, HCRII, KIDCR, P34H, PNTSU, SDR20C1, XR
  • Links
    NCBI Gene ID: 51181
    neXtProt AC: NX_Q7Z4W1
    UniProt: Q7Z4W1

  • Chr Location
    17q25.3; chr17:82035136-82037709 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DCXR associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    858
  • Tissues
    118
  • cDNA Data
    73
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039450 Ensembl Gene Model | MGI Sequence Detail 1883 C57BL/6J ±  kb
transcript ENSMUST00000026144 Ensembl | MGI Sequence Detail 892 Not Applicable  
polypeptide ENSMUSP00000026144 Ensembl | MGI Sequence Detail 244 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006336 L-xylulose reductase
    (term hierarchy)
  • EC
    1.1.1.10
  • InterPro Domains
    IPR051737 L-xylulose reductase/Carbonyl reductase
    IPR036291 NAD(P)-binding domain superfamily
    IPR020904 Short-chain dehydrogenase/reductase, conserved site
    IPR002347 Short-chain dehydrogenase/reductase SDR
  • GlyGen
    Q91X52 4 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 73
    cDNA 73

    Microarray probesets 4
Other
Accession IDs
less
MGI:1917589
References
more
  • Summaries
    All 44
    Developmental Gene Expression 3
    Gene Ontology 10
    Phenotypes 7
  • Earliest
    J:323240 Tulsiani DR, et al., Studies on dehydrogenases of the glucuronate-xylulose cycle in the livers of diabetic mice and rats. Diabetes. 1979 Sep;28(9):793-8
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory