Dennd10 MGI Mouse Gene Detail - MGI:1915144

Symbol

Dennd10
Name

DENN domain containing 10
Synonyms

1810055E12Rik, Fam45a

Feature Type

protein coding gene
IDs

MGI:1915144
NCBI Gene: 67894
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr19:60800023-60824665 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 56.52 cM, cytoband D3
Mapping Data

2 experiments

SNPs within 2kb

685 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915144	protein coding gene	Chr19:60800023-60824673 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025296	protein coding gene	Chr19:61418032-61446320 (+)
A/J	MGP_AJ_G0025272	protein coding gene	Chr19:58416581-58441855 (+)
AKR/J	MGP_AKRJ_G0025241	protein coding gene	Chr19:60238259-60266584 (+)
BALB/cJ	MGP_BALBcJ_G0025267	protein coding gene	Chr19:58501410-58525581 (+)
C3H/HeJ	MGP_C3HHeJ_G0025027	protein coding gene	Chr19:60480602-60511732 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025710	protein coding gene	Chr19:62871633-62899792 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023122	protein coding gene	Chr19:57247429-57267850 (+)
CAST/EiJ	MGP_CASTEiJ_G0024492	protein coding gene	Chr19:60588803-60612240 (+)
CBA/J	MGP_CBAJ_G0025007	protein coding gene	Chr19:65937263-65962420 (+)
DBA/2J	MGP_DBA2J_G0025139	protein coding gene	Chr19:58205035-58229354 (+)
FVB/NJ	MGP_FVBNJ_G0025100	protein coding gene	Chr19:57868329-57893926 (+)
LP/J	MGP_LPJ_G0025225	protein coding gene	Chr19:61251310-61275677 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025133	protein coding gene	Chr19:65127528-65151063 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025768	protein coding gene	Chr19:60484576-60508100 (+)
PWK/PhJ	MGP_PWKPhJ_G0024240	protein coding gene	Chr19:58143974-58169482 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024043	protein coding gene	Chr19:59131487-59156672 (+)
WSB/EiJ	MGP_WSBEiJ_G0024562	protein coding gene	Chr19:60591111-60616211 (+)

Human Ortholog

DENND10, DENN domain containing 10

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DENND10, DENN domain containing 10
Synonyms

FAM45A
Links

HGNC:31793

NCBI Gene ID: 404636

neXtProt AC: NX_Q8TCE6

UniProt: Q8TCE6
Chr Location

10q26.11; chr10:119104086-119137984 (+) GRCh38

Human Ortholog

DENND10P1, DENND10 pseudogene 1
Synonyms

FAM45B, FAM45BP, HT011
Links

HGNC:30886

NCBI Gene ID: 55855
Chr Location

Xq26.1; chrX:130494941-130497448 (+) GRCh38

MGI Vertebrate Homology

Dennd10 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DENND10, DENND10P1
Gene Tree

Dennd10

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Gene trapped

1
Targeted

2
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

14
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

45

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

58
RefSeq

10
UniProt

4
CCDS

CCDS29942.1, CCDS84460.1

Ensembl

ENSMUSG00000024993 (Evidence)
NCBI Gene

67894

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024993	Ensembl Gene Model \| MGI Sequence Detail	24643	C57BL/6J	± kb
transcript	ENSMUST00000025957	Ensembl \| MGI Sequence Detail	2307	Not Applicable
polypeptide	ENSMUSP00000025957	Ensembl \| MGI Sequence Detail	357	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000029473 DENN domain-containing protein 10

(term hierarchy)
InterPro Domains

IPR042431 DENN domain-containing protein 10

IPR037516 Tripartite DENN domain

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All nucleic 45

cDNA 45

Microarray probesets 3

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MGI:6393840

Summaries

All 30

Gene Ontology 4

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dennd10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157365	Chr19:60800012-60800057 (+)	12 bp
Tssr157366	Chr19:60800274-60800317 (+)	273 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24