Hcfc2 MGI Mouse Gene Detail - MGI:1915183

Symbol

Hcfc2
Name

host cell factor C2
Synonyms

1700129L13Rik, fkls

Feature Type

protein coding gene
IDs

MGI:1915183
NCBI Gene: 67933
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr10:82531994-82578262 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.93 cM
Mapping Data

2 experiments

SNPs within 2kb

950 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915183	protein coding gene	Chr10:82531994-82631699 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017579	protein coding gene	Chr10:83438103-83483590 (+)
A/J	MGP_AJ_G0017559	protein coding gene	Chr10:80632231-80678114 (+)
AKR/J	MGP_AKRJ_G0017518	protein coding gene	Chr10:82880548-82925850 (+)
BALB/cJ	MGP_BALBcJ_G0017522	protein coding gene	Chr10:80901098-80947025 (+)
C3H/HeJ	MGP_C3HHeJ_G0017344	protein coding gene	Chr10:82940804-82997341 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017979	protein coding gene	Chr10:86369675-86415695 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015664	protein coding gene	Chr10:76373026-76417230 (+)
CAST/EiJ	MGP_CASTEiJ_G0016911	protein coding gene	Chr10:82857024-82905385 (+)
CBA/J	MGP_CBAJ_G0017314	protein coding gene	Chr10:89926350-89975147 (+)
DBA/2J	MGP_DBA2J_G0017420	protein coding gene	Chr10:79807061-79853058 (+)
FVB/NJ	MGP_FVBNJ_G0017414	protein coding gene	Chr10:79037038-79083520 (+)
LP/J	MGP_LPJ_G0017492	protein coding gene	Chr10:84092583-84140288 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017442	protein coding gene	Chr10:91608992-91655910 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018016	protein coding gene	Chr10:82809923-82856105 (+)
PWK/PhJ	MGP_PWKPhJ_G0016692	protein coding gene	Chr10:79683326-79730927 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016482	protein coding gene	Chr10:81498797-81551250 (+)
WSB/EiJ	MGP_WSBEiJ_G0016970	protein coding gene	Chr10:82845005-82891084 (+)

Human Ortholog

HCFC2, host cell factor C2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HCFC2, host cell factor C2
Synonyms

HCF-2, HCF2
Links

HGNC:24972

NCBI Gene ID: 29915

neXtProt AC: NX_Q9Y5Z7

UniProt: Q9Y5Z7
Chr Location

12q23.3; chr12:104064531-104106524 (+) GRCh38

MGI Vertebrate Homology

Hcfc2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HCFC2
Gene Tree

Hcfc2

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Phenotype Summary

8 phenotypes from 4 alleles in 3 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (ENU)

3
Chemically induced (other)

1
Endonuclease-mediated

2
Genomic Mutations

1 involving Hcfc2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for null or severely hypomorphic allele exhibit reduced poly(I:C)-mediated TLR3 signaling and increased mortality following viral infection.

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All GO Annotations

27
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

829
Tissues

123
cDNA Data

13
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hcfc2

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All Sequences

58
RefSeq

14
UniProt

5
CCDS

CCDS36014.1

Ensembl

ENSMUSG00000020246 (Evidence)
NCBI Gene

67933

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020246	Ensembl Gene Model \| MGI Sequence Detail	46269	C57BL/6J	± kb
transcript	ENSMUST00000020478	Ensembl \| MGI Sequence Detail	3422	Not Applicable
polypeptide	ENSMUSP00000020478	Ensembl \| MGI Sequence Detail	722	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008472 host cell factor 2

(term hierarchy)
PDB

1WFT
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR043536 Host cell factor

IPR013783 Immunoglobulin-like fold

IPR006652 Kelch repeat type 1

IPR015915 Kelch-type beta propeller
GlyGen

Q9D968 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 13

cDNA 13

Microarray probesets 6

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MGI:2143736, MGI:5445583

Summaries

All 35

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 8
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:310903 Gresakova V, et al., Dual role of Fam208a during zygotic cleavage and early embryonic development. Exp Cell Res. 2021 Sep 15;406(2):112723

TSS for Hcfc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94820	Chr10:82533188-82533196 (+)	1,198 bp
Tssr94821	Chr10:82534931-82534983 (+)	2,963 bp
Tssr94822	Chr10:82534993-82535004 (+)	3,005 bp
Tssr94823	Chr10:82535017-82535031 (+)	3,030 bp
Tssr94824	Chr10:82535043-82535052 (+)	3,054 bp
Tssr94825	Chr10:82535063-82535072 (+)	3,074 bp
Tssr94826	Chr10:82543793-82543798 (+)	11,802 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24