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Atad1 Gene Detail
Summary
  • Symbol
    Atad1
  • Name
    ATPase family, AAA domain containing 1
  • Synonyms
    4921525H23Rik, Thorase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915229
    NCBI Gene: 67979
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:32649958-32717187 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 27.55 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1995 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915229
 protein coding gene Chr19:32649038-32717187 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025042
 protein coding gene Chr19:31313860-31359381 (-)
A/J MGP_AJ_G0025019
 protein coding gene Chr19:29756208-29797179 (-)
AKR/J MGP_AKRJ_G0024987
 protein coding gene Chr19:30798350-30839607 (-)
BALB/cJ MGP_BALBcJ_G0025018
 protein coding gene Chr19:29818561-29860562 (-)
C3H/HeJ MGP_C3HHeJ_G0024774
 protein coding gene Chr19:30794930-30836987 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025459
 protein coding gene Chr19:32196941-32237939 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022878
 protein coding gene Chr19:29664785-29703000 (-)
CAST/EiJ MGP_CASTEiJ_G0024245
 protein coding gene Chr19:30702073-30745703 (-)
CBA/J MGP_CBAJ_G0024752
 protein coding gene Chr19:33692718-33739085 (-)
DBA/2J MGP_DBA2J_G0024884
 protein coding gene Chr19:29681264-29723234 (-)
FVB/NJ MGP_FVBNJ_G0024846
 protein coding gene Chr19:29511707-29549694 (-)
LP/J MGP_LPJ_G0024969
 protein coding gene Chr19:31327948-31370797 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024873
 protein coding gene Chr19:33546427-33588601 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025514
 protein coding gene Chr19:30858116-30901009 (-)
PWK/PhJ MGP_PWKPhJ_G0023993
 protein coding gene Chr19:29379147-29426101 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023797
 protein coding gene Chr19:30151366-30272350 (-)
WSB/EiJ MGP_WSBEiJ_G0024311
 protein coding gene Chr19:30885519-30929832 (-)



Homology
more
  • Human Ortholog
    ATAD1, ATPase family AAA domain containing 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATAD1, ATPase family AAA domain containing 1
  • Synonyms
    AFDC1, FNP001, hATAD1, HKPX4, Msp1, THORASE
  • Links
    NCBI Gene ID: 84896
    neXtProt AC: NX_Q8NBU5
    UniProt: Q8NBU5

  • Chr Location
    10q23.31; chr10:87751512-87841361 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ATAD1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased body size, seizure, absent LTD, enhanced LTP, enhanced AMPA-mediated currents, and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    780
  • Tissues
    12
  • cDNA Data
    16
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67979 NCBI Gene Model | MGI Sequence Detail 67230 C57BL/6J ±  kb
    transcript NM_026487 RefSeq | MGI Sequence Detail 2813 C57BL/6  
    polypeptide Q9D5T0 UniProt | EBI | MGI Sequence Detail 361 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000029293 outer mitochondrial transmembrane helix translocase
      (term hierarchy)
    • EC
      7.4.2.-
    • InterPro Domains
      IPR041569 AAA ATPase, AAA+ lid domain
      IPR003593 AAA+ ATPase domain
      IPR003960 ATPase, AAA-type, conserved site
      IPR003959 ATPase, AAA-type, core
      IPR051701 Mitochondrial Outer Membrane Translocase MSP1 Subfamily
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      Q9D5T0 2 sites, 3 N-linked glycans (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2147704
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:340030 Li C, et al., Genetic Deletion of Thorase Causes Purkinje Cell Loss and Impaired Motor Coordination Behavior. Cells. 2023 Aug 10;12(16)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory