Nacc2 MGI Mouse Gene Detail - MGI:1915241 - nucleus accumbens associated 2, BEN and BTB (POZ) domain containing

Symbol

Nacc2
Name

nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
Synonyms

0610020I02Rik, Btbd14a, C030048H19Rik

Feature Type

protein coding gene
IDs

MGI:1915241
NCBI Gene: 67991
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr2:25945547-26012823 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 18.29 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

1517 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915241	protein coding gene	Chr2:25945547-26013232 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025477	protein coding gene	Chr2:23997317-24067237 (-)
A/J	MGP_AJ_G0025454	protein coding gene	Chr2:23069072-23137218 (-)
AKR/J	MGP_AKRJ_G0025424	protein coding gene	Chr2:23820606-23889611 (-)
BALB/cJ	MGP_BALBcJ_G0025450	protein coding gene	Chr2:23179079-23249008 (-)
C3H/HeJ	MGP_C3HHeJ_G0025211	protein coding gene	Chr2:23764997-23853027 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025894	protein coding gene	Chr2:24765017-24842391 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023305	protein coding gene	Chr2:21950115-22021440 (-)
CAST/EiJ	MGP_CASTEiJ_G0024674	protein coding gene	Chr2:23642003-23722618 (-)
CBA/J	MGP_CBAJ_G0025189	protein coding gene	Chr2:25604695-25680371 (-)
DBA/2J	MGP_DBA2J_G0025322	protein coding gene	Chr2:22894071-22963444 (-)
FVB/NJ	MGP_FVBNJ_G0025284	protein coding gene	Chr2:22645578-22713640 (-)
LP/J	MGP_LPJ_G0025408	protein coding gene	Chr2:23931106-24004188 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025315	protein coding gene	Chr2:25772567-25843036 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025953	protein coding gene	Chr2:23783826-23855698 (-)
PWK/PhJ	MGP_PWKPhJ_G0024422	protein coding gene	Chr2:22696303-22765953 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024222	protein coding gene	Chr2:23905133-23978118 (-)
WSB/EiJ	MGP_WSBEiJ_G0024743	protein coding gene	Chr2:23880292-23953994 (-)

Human Ortholog

NACC2, NACC family member 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NACC2, NACC family member 2
Synonyms

BEND9, BTBD14, BTBD14A, BTBD31, NAC-2, RBB
Links

HGNC:23846

NCBI Gene ID: 138151

neXtProt AC: NX_Q96BF6

UniProt: Q96BF6
Chr Location

9q34.3; chr9:136006537-136095289 (-) GRCh38

MGI Vertebrate Homology

Nacc2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: NACC2
Gene Tree

Nacc2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Endonuclease-mediated

1
Gene trapped

21
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

33
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

845
Tissues

13
cDNA Data

68
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nacc2

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All Sequences

82
RefSeq

8
UniProt

3
CCDS

CCDS15796.1

Ensembl

ENSMUSG00000026932 (Evidence)
NCBI Gene

67991

			Length	Strain/Species	Flank
genomic	67991	NCBI Gene Model \| MGI Sequence Detail	67277	C57BL/6J	± kb
transcript	NM_001037098	RefSeq \| MGI Sequence Detail	6893	C57BL/6
polypeptide	Q9DCM7	UniProt \| EBI \| MGI Sequence Detail	586	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010954 nucleus accumbens-associated protein 2

(term hierarchy)
InterPro Domains

IPR018379 BEN domain

IPR000210 BTB/POZ domain

IPR011333 SKP1/BTB/POZ domain superfamily

IPR050457 Zinc finger and BTB domain-containing

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All nucleic 68

cDNA 68

Microarray probesets 6

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MGI:1915386, MGI:2138951

Summaries

All 42

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nacc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr23075	Chr2:26012781-26012850 (-)	7 bp
Tssr23074	Chr2:26012750-26012777 (-)	59 bp
Tssr23073	Chr2:25987263-25987271 (-)	25,556 bp
Tssr23072	Chr2:25982161-25982169 (-)	30,658 bp
Tssr23071	Chr2:25982060-25982071 (-)	30,757 bp
Tssr23070	Chr2:25982030-25982045 (-)	30,785 bp
Tssr23069	Chr2:25982004-25982015 (-)	30,813 bp
Tssr23068	Chr2:25981973-25982000 (-)	30,836 bp
Tssr23067	Chr2:25981945-25981971 (-)	30,865 bp
Tssr23066	Chr2:25981926-25981935 (-)	30,892 bp
Tssr23065	Chr2:25981843-25981867 (-)	30,968 bp
Tssr23064	Chr2:25981788-25981803 (-)	31,027 bp
Tssr23063	Chr2:25962688-25962689 (-)	50,134 bp
Tssr23062	Chr2:25952342-25952354 (-)	60,475 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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