Srsf6 MGI Mouse Gene Detail - MGI:1915246 - serine and arginine-rich splicing factor 6

Symbol

Srsf6
Name

serine and arginine-rich splicing factor 6
Synonyms

1210001E11Rik, Sfrs6

Feature Type

protein coding gene
IDs

MGI:1915246
NCBI Gene: 67996
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr2:162773448-162779041 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 83.87 cM
Mapping Data

3 experiments

SNPs within 2kb

134 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915246	protein coding gene	Chr2:162773428-162779041 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026813	protein coding gene	Chr2:168209371-168214963 (+)
A/J	MGP_AJ_G0026779	protein coding gene	Chr2:161465419-161471012 (+)
AKR/J	MGP_AKRJ_G0026750	protein coding gene	Chr2:166221985-166230541 (+)
BALB/cJ	MGP_BALBcJ_G0026788	protein coding gene	Chr2:161784663-161790256 (+)
C3H/HeJ	MGP_C3HHeJ_G0026530	protein coding gene	Chr2:166571570-166578477 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027236	protein coding gene	Chr2:173159180-173164774 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024606	protein coding gene	Chr2:154759664-154765028 (+)
CAST/EiJ	MGP_CASTEiJ_G0025991	protein coding gene	Chr2:166931298-166936893 (+)
CBA/J	MGP_CBAJ_G0026507	protein coding gene	Chr2:179408259-179418641 (+)
DBA/2J	MGP_DBA2J_G0026645	protein coding gene	Chr2:160634991-160641200 (+)
FVB/NJ	MGP_FVBNJ_G0026611	protein coding gene	Chr2:159004375-159009882 (+)
LP/J	MGP_LPJ_G0026748	protein coding gene	Chr2:168358719-168364311 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026633	protein coding gene	Chr2:183103777-183109371 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027292	protein coding gene	Chr2:166104694-166110288 (+)
PWK/PhJ	MGP_PWKPhJ_G0025725	protein coding gene	Chr2:160177206-160183018 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025528	protein coding gene	Chr2:164976791-164984160 (+)
WSB/EiJ	MGP_WSBEiJ_G0026061	protein coding gene	Chr2:166975376-166980968 (+)

Human Ortholog

SRSF6, serine and arginine rich splicing factor 6

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SRSF6, serine and arginine rich splicing factor 6
Synonyms

B52, HEL-S-91, SFRS6, SRP55
Links

HGNC:10788

NCBI Gene ID: 6431

neXtProt AC: NX_Q13247

UniProt: Q13247
Chr Location

20q13.11; chr20:43457893-43466046 (+) GRCh38

MGI Vertebrate Homology

Srsf6 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SRSF6
Gene Tree

Srsf6

Diseases

2 with human SRSF6 associations

				Human Disease	Mouse Models
				proliferative diabetic retinopathy IDs proliferative diabetic retinopathy DOID:13207 ICD9CM:362.02 NCI:C84457 UMLS_CUI:C0154830
				spermatogenic failure 3 IDs spermatogenic failure 3 DOID:0070168 OMIM:606766

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

3
Gene trapped

5
Targeted

1
Incidental Mutations

APF
Find Mice (IMSR)

33 strains or lines available

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All GO Annotations

29
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

782
Tissues

30
cDNA Data

17
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase srsf6

ZFIN srsf6a, srsf6b

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All Sequences

66
RefSeq

2
UniProt

3
CCDS

CCDS17002.1

Ensembl

ENSMUSG00000016921 (Evidence)
NCBI Gene

67996

			Length	Strain/Species	Flank
genomic	ENSMUSG00000016921	Ensembl Gene Model \| MGI Sequence Detail	5594	C57BL/6J	± kb
transcript	ENSMUST00000130411	Ensembl \| MGI Sequence Detail	3527	Not Applicable
polypeptide	ENSMUSP00000119065	Ensembl \| MGI Sequence Detail	339	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014763 serine/arginine-rich splicing factor 6

(term hierarchy)
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR050374 RRT5/SRSF/Splicing Factor SR

IPR034511 SRSF6, RNA recognition motif 1
GlyGen

Q3TWW8 1 site, 1 O-linked glycan (1 site)

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All nucleic 20

Genomic 2

cDNA 17

Primer pair 1

Microarray probesets 9

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MGI:2138887, MGI:2147715, MGI:2152843

Summaries

All 47

Developmental Gene Expression 6

Gene Ontology 7

Phenotypes 10
Earliest

J:66467 Pazzaglia S, et al., Somatic cell hybrids for high-density mapping of chromosome 2 breakpoints in radiation-induced myeloid leukemia cell lines from inbred mice. Mol Carcinog. 2000 Mar;27(3):219-28
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Srsf6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21420	Chr2:162773440-162773456 (+)	0 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24