Retreg3 MGI Mouse Gene Detail - MGI:1915248 - reticulophagy regulator family member 3

Symbol

Retreg3
Name

reticulophagy regulator family member 3
Synonyms

1300010M03Rik, 4933404C01Rik, Fam134c

Feature Type

protein coding gene
IDs

MGI:1915248
NCBI Gene: 67998
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:100987148-101010719 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 64.20 cM
Mapping Data

2 experiments

SNPs within 2kb

484 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915248	protein coding gene	Chr11:100987148-101010720 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019181	protein coding gene	Chr11:103907144-103934312 (-)
A/J	MGP_AJ_G0019149	protein coding gene	Chr11:99553600-99578286 (-)
AKR/J	MGP_AKRJ_G0019118	protein coding gene	Chr11:102650633-102675203 (-)
BALB/cJ	MGP_BALBcJ_G0019123	protein coding gene	Chr11:100048108-100071448 (-)
C3H/HeJ	MGP_C3HHeJ_G0018932	protein coding gene	Chr11:102820555-102844070 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019572	protein coding gene	Chr11:107122263-107157494 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017198	protein coding gene	Chr11:96971983-96996635 (-)
CAST/EiJ	MGP_CASTEiJ_G0018486	protein coding gene	Chr11:103808870-103834086 (-)
CBA/J	MGP_CBAJ_G0018901	protein coding gene	Chr11:111586100-111616352 (-)
DBA/2J	MGP_DBA2J_G0019013	protein coding gene	Chr11:99088613-99111936 (-)
FVB/NJ	MGP_FVBNJ_G0019003	protein coding gene	Chr11:98631958-98655425 (-)
LP/J	MGP_LPJ_G0019082	protein coding gene	Chr11:104457003-104481453 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019034	protein coding gene	Chr11:111154640-111179439 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019610	protein coding gene	Chr11:102970175-102993585 (-)
PWK/PhJ	MGP_PWKPhJ_G0018249	protein coding gene	Chr11:100139451-100163290 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018041	protein coding gene	Chr11:102705284-102733343 (-)
WSB/EiJ	MGP_WSBEiJ_G0018535	protein coding gene	Chr11:102968543-102996114 (-)

Human Ortholog

RETREG3, reticulophagy regulator family member 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RETREG3, reticulophagy regulator family member 3
Synonyms

FAM134C
Links

HGNC:27258

NCBI Gene ID: 162427

neXtProt AC: NX_Q86VR2

UniProt: Q86VR2
Chr Location

17q21.2; chr17:42579508-42610623 (-) GRCh38

MGI Vertebrate Homology

Retreg3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RETREG3
Gene Tree

Retreg3

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Gene trapped

1
Targeted

6
Genomic Mutations

1 involving Retreg3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

16
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

34
cDNA Data

15
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase retreg3

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All Sequences

64
RefSeq

10
UniProt

1
CCDS

CCDS25449.1, CCDS25450.1

Ensembl

ENSMUSG00000017802 (Evidence)
NCBI Gene

67998

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017802	Ensembl Gene Model \| MGI Sequence Detail	23572	C57BL/6J	± kb
transcript	ENSMUST00000017946	Ensembl \| MGI Sequence Detail	3165	Not Applicable
polypeptide	ENSMUSP00000017946	Ensembl \| MGI Sequence Detail	466	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000029462 reticulophagy regulator 3

(term hierarchy)
InterPro Domains

IPR043384 Reticulophagy receptor 1/3
GlyGen

Q9CQV4 1 site, 1 N-linked glycan (1 site)

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All nucleic 15

cDNA 15

Microarray probesets 7

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MGI:1921678, MGI:2144219, MGI:5897462

Summaries

All 45

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 17
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:354136 Iavarone F, et al., Fam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo. EMBO Rep. 2024 Jul 22;

TSS for Retreg3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110914	Chr11:101010715-101010726 (-)	-2 bp
Tssr110913	Chr11:101010682-101010705 (-)	25 bp
Tssr110912	Chr11:101010640-101010675 (-)	61 bp
Tssr110911	Chr11:101010612-101010630 (-)	98 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24