Bambi MGI Mouse Gene Detail - MGI:1915260 - BMP and activin membrane-bound inhibitor

Symbol

Bambi
Name

BMP and activin membrane-bound inhibitor
Synonyms

2610003H06Rik

Feature Type

protein coding gene
IDs

MGI:1915260
NCBI Gene: 68010
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr18:3507923-3516404 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 2.30 cM, cytoband A1
Mapping Data

2 experiments

SNPs within 2kb

232 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915260	protein coding gene	Chr18:3507011-3516404 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024120	protein coding gene	Chr18:299713-308160 (+)
A/J	MGP_AJ_G0024082	protein coding gene	Chr18:347523-355956 (+)
AKR/J	MGP_AKRJ_G0024050	protein coding gene	Chr18:350287-358721 (+)
BALB/cJ	MGP_BALBcJ_G0024082	protein coding gene	Chr18:375620-384064 (+)
C3H/HeJ	MGP_C3HHeJ_G0023847	protein coding gene	Chr18:318004-326450 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024527	protein coding gene	Chr18:390301-398748 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021966	protein coding gene	Chr18:290905-300578 (+)
CAST/EiJ	MGP_CASTEiJ_G0023326	protein coding gene	Chr18:315998-324361 (+)
CBA/J	MGP_CBAJ_G0023821	protein coding gene	Chr18:360024-368470 (+)
DBA/2J	MGP_DBA2J_G0023949	protein coding gene	Chr18:306810-315246 (+)
FVB/NJ	MGP_FVBNJ_G0023915	protein coding gene	Chr18:311726-321808 (+)
LP/J	MGP_LPJ_G0024033	protein coding gene	Chr18:356806-365253 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023943	protein coding gene	Chr18:364608-373103 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024572	protein coding gene	Chr18:319583-328018 (+)
PWK/PhJ	MGP_PWKPhJ_G0023071	protein coding gene	Chr18:349807-358358 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022882	protein coding gene	Chr18:570001-578474 (+)
WSB/EiJ	MGP_WSBEiJ_G0023392	protein coding gene	Chr18:337778-346224 (+)

Human Ortholog

BAMBI, BMP and activin membrane bound inhibitor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BAMBI, BMP and activin membrane bound inhibitor
Synonyms

NMA
Links

HGNC:30251

NCBI Gene ID: 25805

neXtProt AC: NX_Q13145

UniProt: Q13145
Chr Location

10p12.1; chr10:28677510-28682932 (+) GRCh38

MGI Vertebrate Homology

Bambi stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: BAMBI
Protein SuperFamily

BAMBI
Gene Tree

Bambi

Diseases

1 with human BAMBI associations

				Human Disease	Mouse Models
				colorectal cancer IDs colorectal cancer DOID:9256 ICD10CM:C18.9 KEGG:05210 MESH:D015179 NCI:C2956 NCI:C4978 OMIM:114500 UMLS_CUI:C0009404 UMLS_CUI:C0346629

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

12 phenotypes from 4 alleles in 4 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Targeted

5
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Female mice homozygous for a null allele weigh 9% to 10% less than wild-type female mice. Male mice are unaffected. Mice homozygous for one knock-out allele exhibit increased chemical, thermal, and mechanical nociception and decreased nerve injury-induced allodynia.

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All GO Annotations

29
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1397
Tissues

257
cDNA Data

33
Literature Summary

25

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA BAMBI

Xenbase bambi

ZFIN bambia

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All Sequences

41
RefSeq

4
UniProt

2
CCDS

CCDS29034.1

Ensembl

ENSMUSG00000024232 (Evidence)
NCBI Gene

68010

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024232	Ensembl Gene Model \| MGI Sequence Detail	8482	C57BL/6J	± kb
transcript	ENSMUST00000025075	Ensembl \| MGI Sequence Detail	5074	Not Applicable
polypeptide	ENSMUSP00000025075	Ensembl \| MGI Sequence Detail	260	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004636 BMP and activin membrane-bound inhibitor

(term hierarchy)
InterPro Domains

IPR009345 BMP and activin membrane-bound inhibitor

IPR045806 BMP and activin membrane-bound inhibitor, C-terminal domain

IPR045807 BMP and activin membrane-bound inhibitor, N-terminal domain

IPR045860 Snake toxin-like superfamily
GlyGen

Q9D0L6 1 site

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All nucleic 42

cDNA 35

Primer pair 7

Microarray probesets 2

Summaries

All 67

Developmental Gene Expression 25

Gene Ontology 4

Phenotypes 20
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Bambi:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr149895	Chr18:3507917-3507943 (+)	7 bp
Tssr149896	Chr18:3507945-3507964 (+)	32 bp
Tssr149897	Chr18:3507981-3507992 (+)	64 bp
Tssr149898	Chr18:3508002-3508014 (+)	85 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24