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Mrm2 Gene Detail
Summary
  • Symbol
    Mrm2
  • Name
    mitochondrial rRNA methyltransferase 2
  • Synonyms
    2310037B18Rik, Ftsj2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915267
    NCBI Gene: 68017
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:140313429-140317653 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 78.94 cM, cytoband G1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    284 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915267
 protein coding gene Chr5:140313429-140317653 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030297
 protein coding gene Chr5:145387609-145391835 (-)
A/J MGP_AJ_G0030266
 protein coding gene Chr5:139203628-139207852 (-)
AKR/J MGP_AKRJ_G0030198
 protein coding gene Chr5:143550481-143554705 (-)
BALB/cJ MGP_BALBcJ_G0030283
 protein coding gene Chr5:140448535-140452759 (-)
C3H/HeJ MGP_C3HHeJ_G0029994
 protein coding gene Chr5:144327688-144331914 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030728
 protein coding gene Chr5:150774809-150779033 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027946
 protein coding gene Chr5:133049954-133053759 (-)
CAST/EiJ MGP_CASTEiJ_G0029399
 protein coding gene Chr5:143761143-143764776 (-)
CBA/J MGP_CBAJ_G0029964
 protein coding gene Chr5:156962813-156967039 (-)
DBA/2J MGP_DBA2J_G0030114
 protein coding gene Chr5:139016081-139020307 (-)
FVB/NJ MGP_FVBNJ_G0030069
 protein coding gene Chr5:138158889-138163113 (-)
LP/J MGP_LPJ_G0030200
 protein coding gene Chr5:146001396-146005620 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030100
 protein coding gene Chr5:159558413-159562637 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030768
 protein coding gene Chr5:143382512-143386740 (-)
PWK/PhJ MGP_PWKPhJ_G0029114
 protein coding gene Chr5:138037214-138041815 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028950
 protein coding gene Chr5:141082592-141086149 (-)
WSB/EiJ MGP_WSBEiJ_G0029473
 protein coding gene Chr5:144167731-144171334 (-)



Homology
more
  • Human Ortholog
    MRM2, mitochondrial rRNA methyltransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRM2, mitochondrial rRNA methyltransferase 2
  • Synonyms
    FJH1, FTSJ2, HEL97, MTDPS17, RRMJ2
  • Links
    NCBI Gene ID: 29960
    neXtProt AC: NX_Q9UI43
    UniProt: Q9UI43

  • Chr Location
    7p22.3; chr7:2234195-2242205 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MRM2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68017 NCBI Gene Model | MGI Sequence Detail 4225 C57BL/6J ±  kb
    transcript NM_026510 RefSeq | MGI Sequence Detail 1443 C57BL/6  
    polypeptide Q9CPY0 UniProt | EBI | MGI Sequence Detail 246 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000031650 rRNA methyltransferase 2, mitochondrial
      (term hierarchy)
    • EC
      2.1.1.-
    • InterPro Domains
      IPR015507 Ribosomal RNA large subunit methyltransferase E
      IPR050082 Ribosomal RNA large subunit methyltransferase RlmE
      IPR002877 Ribosomal RNA methyltransferase, FtsJ domain
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 25

      Microarray probesets 2
    References
    more
    • Summaries
      All 34
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:172928 Segal DM, et al., A nucleolar 2'-O-methyltransferase. Specificity and evidence for its role in the methylation of mouse 28 S precursor ribosomal RNA. J Biol Chem. 1991 Dec 25;266(36):24385-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/17/2024
    MGI 6.24     		The Jackson Laboratory