H2bc4 MGI Mouse Gene Detail - MGI:1915274

Symbol

H2bc4
Name

H2B clustered histone 4
Synonyms

2610022J01Rik, H2bfs, Hist1h2bc

Feature Type

protein coding gene
IDs

MGI:1915274
NCBI Gene: 68024
Member of

Hist1 cluster
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr13:23868182-23876805 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 9.87 cM, cytoband A2-A3
Mapping Data

3 experiments

SNPs within 2kb

394 from dbSNP Build 142
Strain Annotations

10

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915274	protein coding gene	Chr13:23868182-23876891 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020355	protein coding gene	Chr13:21117647-21126410 (+)
A/J	no annotation
AKR/J	MGP_AKRJ_G0020287	protein coding gene	Chr13:20984691-20993394 (+)
BALB/cJ	no annotation
C3H/HeJ	MGP_C3HHeJ_G0020108	protein coding gene	Chr13:21052554-21061870 (+)
C57BL/6NJ	no annotation
CAROLI/EiJ	MGP_CAROLIEiJ_G0018327	protein coding gene	Chr13:19517517-19525629 (+)
CAST/EiJ	MGP_CASTEiJ_G0019625	protein coding gene	Chr13:20735912-20744338 (+)
CBA/J	no annotation
DBA/2J	MGP_DBA2J_G0020187	protein coding gene	Chr13:20263033-20271536 (+)
FVB/NJ	no annotation
LP/J	MGP_LPJ_G0020259	protein coding gene	Chr13:21428779-21438430 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020199	protein coding gene	Chr13:23043964-23054716 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020781	protein coding gene	Chr13:20833742-20842809 (+)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

H2BC10, H2B clustered histone 10

Vertebrate Orthologs

12

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

H2BC10, H2B clustered histone 10
Synonyms

H2BC4, H2BC6, H2BC7, H2BC8, H2BFK, H2B/k, HIST1H2BI
Links

HGNC:4756

NCBI Gene ID: 8346

neXtProt AC: NX_P62807

UniProt: P62807
Chr Location

6p22.2; chr6:26272931-26273412 (+) GRCh38

Human Ortholog

H2BC5, H2B clustered histone 5
Synonyms

dJ221C16.6, H2B.1B, H2B/a, H2B/b, H2BFA, H2BFB, H2BFG, H2BFH, H2BFK, H2BFL, H2B/g, H2B/h, H2B/k, H2B/l, HIRIP2, HIST1H2BC, HIST1H2BD, HIST1H2BE, HIST1H2BF, HIST1H2BG, HIST1H2BI
Links

HGNC:4747

NCBI Gene ID: 3017

neXtProt AC: NX_P58876, NX_P62807

UniProt: P58876
Chr Location

6p22.2; chr6:26158121-26171349 (+) GRCh38

Human Ortholog

H2BC6, H2B clustered histone 6
Synonyms

dJ221C16.8, H2BC10, H2BC4, H2BC7, H2BC8, H2BFH, H2B.h, H2B/h, HIST1H2BE
Links

HGNC:4753

NCBI Gene ID: 8344

neXtProt AC: NX_P62807

UniProt: P62807
Chr Location

6p22.2; chr6:26172059-26184655 (+) GRCh38

Human Ortholog

H2BC8, H2B clustered histone 8
Synonyms

dJ221C16.8, H2B.1A, H2B/a, H2BC10, H2BC4, H2BC6, H2BC7, H2BFA, HIST1H2BG
Links

HGNC:4746

NCBI Gene ID: 8339

neXtProt AC: NX_P62807

UniProt: P62807
Chr Location

6p22.2; chr6:26216200-26216688 (-) GRCh38

MGI Vertebrate Homology

H2bc4 stringent orthology
4 human;1 mouse;7 rat;1 zebrafish
HCOP

vertebrate homology predictions: H2BC10, H2BC5, H2BC6, H2BC8
Gene Tree

H2bc4

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

39
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

36
Radiation induced

1
Genomic Mutations

2 involving H2bc4
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

934
Tissues

154
cDNA Data

134
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

32
RefSeq

5
CCDS

CCDS26357.1

Ensembl

ENSMUSG00000018102 (Evidence)
NCBI Gene

68024

			Length	Strain/Species	Flank
genomic	68024	NCBI Gene Model \| MGI Sequence Detail	8624	C57BL/6J	± kb
transcript	NM_023422	RefSeq \| MGI Sequence Detail	728	C57BL/6
polypeptide	NP_075911	RefSeq \| MGI Sequence Detail	126	C57BL/6

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All nucleic 138

Genomic 1

cDNA 134

Primer pair 2

Other 1

Microarray probesets 2

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MGI:2145542, MGI:6324972

Summaries

All 45

Developmental Gene Expression 7

Gene Ontology 1

Phenotypes 15
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for H2bc4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118846	Chr13:23868175-23868191 (+)	1 bp
Tssr118847	Chr13:23869778-23869792 (+)	1,603 bp
Tssr118848	Chr13:23876074-23876101 (+)	7,906 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24