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Tmem178 Gene Detail
Summary
  • Symbol
    Tmem178
  • Name
    transmembrane protein 178
  • Synonyms
    2810417M05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915277
    NCBI Gene: 68027
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:81252061-81309245 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 50.97 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1903 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915277
 protein coding gene Chr17:81252061-81309245 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024067
 protein coding gene Chr17:83909784-83977579 (+)
A/J MGP_AJ_G0024025
 protein coding gene Chr17:81326452-81386266 (+)
AKR/J MGP_AKRJ_G0023994
 protein coding gene Chr17:82611390-82673049 (+)
BALB/cJ MGP_BALBcJ_G0024027
 protein coding gene Chr17:81189250-81245858 (+)
C3H/HeJ MGP_C3HHeJ_G0023791
 protein coding gene Chr17:83462457-83521911 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024471
 protein coding gene Chr17:86941001-87003783 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021911
 protein coding gene Chr17:76672421-76730119 (+)
CAST/EiJ MGP_CASTEiJ_G0023270
 protein coding gene Chr17:84166391-84236793 (+)
CBA/J MGP_CBAJ_G0023765
 protein coding gene Chr17:90583471-90640642 (+)
DBA/2J MGP_DBA2J_G0023894
 protein coding gene Chr17:79807449-79865527 (+)
FVB/NJ MGP_FVBNJ_G0023860
 protein coding gene Chr17:79302669-79359049 (+)
LP/J MGP_LPJ_G0023977
 protein coding gene Chr17:84745162-84802788 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023888
 protein coding gene Chr17:90594180-90658298 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024516
 protein coding gene Chr17:83090753-83150996 (+)
PWK/PhJ MGP_PWKPhJ_G0023016
 protein coding gene Chr17:79378288-79462226 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022827
 protein coding gene Chr17:79877200-79960202 (+)
WSB/EiJ MGP_WSBEiJ_G0023338
 protein coding gene Chr17:83917179-83977441 (+)



Homology
more
  • Human Ortholog
    TMEM178A, transmembrane protein 178A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM178A, transmembrane protein 178A
  • Synonyms
    TMEM178
  • Links
    NCBI Gene ID: 130733
    neXtProt AC: NX_Q8NBL3
    UniProt: Q8NBL3

  • Chr Location
    2p22.1; chr2:39664982-39735960 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    5 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased bone mass, osteopenia, and increased osteoclast differentiation under basal and inflammatory conditions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    7
  • cDNA Data
    8
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68027 NCBI Gene Model | MGI Sequence Detail 57185 C57BL/6J ±  kb
    transcript NM_026516 RefSeq | MGI Sequence Detail 1696 Not Specified  
    polypeptide Q9CZ16 UniProt | EBI | MGI Sequence Detail 297 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 3
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 3
      Gene Ontology 2
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:350050 Khanna K, et al., Tmem178 Negatively Regulates IL-1beta Production Through Inhibition of the NLRP3 Inflammasome. Arthritis Rheumatol. 2024 Jan;76(1):107-118
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory