Nmb MGI Mouse Gene Detail - MGI:1915289

Symbol

Nmb
Name

neuromedin B
Synonyms

3110023K12Rik

Feature Type

protein coding gene
IDs

MGI:1915289
NCBI Gene: 68039
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr7:80551975-80554810 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 45.71 cM, cytoband D2
Mapping Data

2 experiments

SNPs within 2kb

171 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915289	protein coding gene	Chr7:80551975-80554824 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032421	protein coding gene	Chr7:82912186-82915027 (-)
A/J	MGP_AJ_G0032400	protein coding gene	Chr7:80964536-80967373 (-)
AKR/J	MGP_AKRJ_G0032336	protein coding gene	Chr7:82732389-82735226 (-)
BALB/cJ	MGP_BALBcJ_G0032412	protein coding gene	Chr7:80634191-80637018 (-)
C3H/HeJ	MGP_C3HHeJ_G0032125	protein coding gene	Chr7:83372679-83375526 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032904	protein coding gene	Chr7:86159851-86163011 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029912	protein coding gene	Chr7:83470813-83473657 (-)
CAST/EiJ	MGP_CASTEiJ_G0031453	protein coding gene	Chr7:74276316-74279157 (-)
CBA/J	MGP_CBAJ_G0032091	protein coding gene	Chr7:89029894-89032754 (-)
DBA/2J	MGP_DBA2J_G0032246	protein coding gene	Chr7:79511596-79514423 (-)
FVB/NJ	MGP_FVBNJ_G0032201	protein coding gene	Chr7:79446095-79448920 (-)
LP/J	MGP_LPJ_G0032327	protein coding gene	Chr7:84152881-84155706 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032238	protein coding gene	Chr7:89152233-89155070 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032922	protein coding gene	Chr7:82168566-82171406 (-)
PWK/PhJ	MGP_PWKPhJ_G0031173	protein coding gene	Chr7:72716249-72719096 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031014	protein coding gene	Chr7:69186099-69188585 (-)
WSB/EiJ	MGP_WSBEiJ_G0031571	protein coding gene	Chr7:82527025-82529846 (-)

Human Ortholog

NMB, neuromedin B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NMB, neuromedin B
Links

HGNC:7842

NCBI Gene ID: 4828

neXtProt AC: NX_P08949

UniProt: P08949
Chr Location

15q25.2; chr15:84655129-84658563 (-) GRCh38

MGI Vertebrate Homology

Nmb stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NMB
Gene Tree

Nmb

Diseases

1 with human NMB associations

				Human Disease	Mouse Models
				obesity IDs obesity DOID:9970 EFO:0001073 ICD10CM:E66.9 ICD9CM:278.00 MESH:D009765 NCI:C159658 OMIM:601665 UMLS_CUI:C0028754

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

2
Targeted

6
Genomic Mutations

3 involving Nmb
Incidental Mutations

APF
Find Mice (IMSR)

9 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knockout allele exhibit attenuated scratching in response to histamine, compound 48/80 and 5-HT.

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All GO Annotations

22
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

771
Tissues

39
cDNA Data

19
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nmb

ZFIN nmba

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All Sequences

40
RefSeq

4
UniProt

2
CCDS

CCDS21400.1, CCDS80742.1

Ensembl

ENSMUSG00000025723 (Evidence)
NCBI Gene

68039

			Length	Strain/Species	Flank
genomic	68039	NCBI Gene Model \| MGI Sequence Detail	2836	C57BL/6J	± kb
transcript	NM_026523	RefSeq \| MGI Sequence Detail	692	Not Specified
polypeptide	Q9CR53	UniProt \| EBI \| MGI Sequence Detail	121	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000011279 neuromedin-B

(term hierarchy)
InterPro Domains

IPR000874 Bombesin/neuromedin-B/ranatensin peptide family

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All nucleic 19

cDNA 19

Microarray probesets 3

Summaries

All 58

Developmental Gene Expression 6

Gene Ontology 9

Phenotypes 22
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nmb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr73313	Chr7:80554808-80554829 (-)	-9 bp
Tssr73312	Chr7:80554760-80554774 (-)	43 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24