Serpina12 MGI Mouse Gene Detail - MGI:1915304 - serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12

Symbol

Serpina12
Name

serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
Synonyms

vaspin

Feature Type

protein coding gene
IDs

MGI:1915304
NCBI Gene: 68054
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr12:103995028-104010702 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 53.05 cM, cytoband F1
Mapping Data

2 experiments

SNPs within 2kb

577 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915304	protein coding gene	Chr12:103995028-104010702 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020065	protein coding gene	Chr12:105781978-105797989 (-)
A/J	MGP_AJ_G0020019	protein coding gene	Chr12:101790931-101806595 (-)
AKR/J	MGP_AKRJ_G0019997	protein coding gene	Chr12:104628771-104644830 (-)
BALB/cJ	MGP_BALBcJ_G0020005	protein coding gene	Chr12:102083876-102099869 (-)
C3H/HeJ	MGP_C3HHeJ_G0019809	protein coding gene	Chr12:105155707-105171363 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020452	protein coding gene	Chr12:109096519-109112179 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018068	protein coding gene	Chr12:98462735-98480172 (-)
CAST/EiJ	MGP_CASTEiJ_G0019349	protein coding gene	Chr12:99887042-99902751 (-)
CBA/J	MGP_CBAJ_G0019776	protein coding gene	Chr12:113112473-113128468 (-)
DBA/2J	MGP_DBA2J_G0019892	protein coding gene	Chr12:101206586-101223095 (-)
FVB/NJ	MGP_FVBNJ_G0019878	protein coding gene	Chr12:100014743-100030447 (-)
LP/J	MGP_LPJ_G0019967	protein coding gene	Chr12:105621340-105637349 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019916	protein coding gene	Chr12:116576183-116593408 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020480	protein coding gene	Chr12:104135604-104151264 (-)
PWK/PhJ	MGP_PWKPhJ_G0019113	protein coding gene	Chr12:95769393-95785171 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018913	protein coding gene	Chr12:98333657-98349950 (-)
WSB/EiJ	MGP_WSBEiJ_G0019408	protein coding gene	Chr12:104984884-105000545 (-)

Human Ortholog

SERPINA12, serpin family A member 12

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SERPINA12, serpin family A member 12
Synonyms

OL-64
Links

HGNC:18359

NCBI Gene ID: 145264

neXtProt AC: NX_Q8IW75

UniProt: Q8IW75
Chr Location

14q32.13; chr14:94487274-94517844 (-) GRCh38

MGI Vertebrate Homology

Serpina12 stringent orthology
1 human;1 mouse;1 rat;5 zebrafish
HCOP

vertebrate homology predictions: SERPINA12
Gene Tree

Serpina12

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Phenotype Summary

20 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

4
Transgenic

3
Genomic Mutations

1 involving Serpina12
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice hmomozygous for a knock-out allele exhibit increased body weight, epididymal fat pad weight, liver weight, fat cell size, serum total and small density LDL cholesterol, serum leptin, liver triglyceride and insulin resistance when fed a high fat, high sucrose diet.

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All GO Annotations

15
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

2
cDNA Data

12
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS26145.1

Ensembl

ENSMUSG00000041567 (Evidence)
NCBI Gene

68054

			Length	Strain/Species	Flank
genomic	68054	NCBI Gene Model \| MGI Sequence Detail	15675	C57BL/6J	± kb
transcript	NM_026535	RefSeq \| MGI Sequence Detail	3690	C57BL/6
polypeptide	Q7TMF5	UniProt \| EBI \| MGI Sequence Detail	413	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014681 serpin A12

(term hierarchy)
InterPro Domains

IPR023795 Serpin, conserved site

IPR023796 Serpin domain

IPR000215 Serpin family

IPR036186 Serpin superfamily

IPR042178 Serpin superfamily, domain 1

IPR042185 Serpin superfamily, domain 2
GlyGen

Q7TMF5 2 sites

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 4

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Serpina12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr117569	Chr12:104010690-104010706 (-)	4 bp
Tssr117568	Chr12:104010634-104010649 (-)	60 bp
Tssr117567	Chr12:104010609-104010625 (-)	85 bp
Tssr117566	Chr12:104010547-104010558 (-)	149 bp
Tssr117565	Chr12:104002090-104002111 (-)	8,601 bp
Tssr117564	Chr12:104002069-104002079 (-)	8,628 bp
Tssr117563	Chr12:103999129-103999152 (-)	11,561 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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