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Pdcd2l Gene Detail
Summary
  • Symbol
    Pdcd2l
  • Name
    programmed cell death 2-like
  • Synonyms
    6030457N17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915329
    NCBI Gene: 68079
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:33883924-33896086 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 19.45 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    525 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915329
 protein coding gene Chr7:33883922-33896154 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032073
 protein coding gene Chr7:33441777-33454381 (-)
A/J MGP_AJ_G0032052
 protein coding gene Chr7:32617491-32631001 (-)
AKR/J MGP_AKRJ_G0031986
 protein coding gene Chr7:33395065-33407239 (-)
BALB/cJ MGP_BALBcJ_G0032060
 protein coding gene Chr7:32901433-32921630 (-)
C3H/HeJ MGP_C3HHeJ_G0031777
 protein coding gene Chr7:34280443-34293137 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032537
 protein coding gene Chr7:35156027-35170579 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029570
 protein coding gene Chr7:33357668-33370433 (-)
CAST/EiJ MGP_CASTEiJ_G0031112
 protein coding gene Chr7:25398351-25410005 (-)
CBA/J MGP_CBAJ_G0031745
 protein coding gene Chr7:36243573-36259251 (-)
DBA/2J MGP_DBA2J_G0031897
 protein coding gene Chr7:32473795-32485232 (-)
FVB/NJ MGP_FVBNJ_G0031852
 protein coding gene Chr7:32382432-32395113 (-)
LP/J MGP_LPJ_G0031974
 protein coding gene Chr7:33813551-33828426 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031890
 protein coding gene Chr7:35298225-35313215 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032552
 protein coding gene Chr7:32914512-32928406 (-)
PWK/PhJ MGP_PWKPhJ_G0030834
 protein coding gene Chr7:25783616-25796456 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030669
 protein coding gene Chr7:22478939-22499051 (-)
WSB/EiJ MGP_WSBEiJ_G0031222
 protein coding gene Chr7:33461070-33471720 (-)



Homology
more
  • Human Ortholog
    PDCD2L, programmed cell death 2 like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDCD2L, programmed cell death 2 like
  • Links
    NCBI Gene ID: 84306
    neXtProt AC: NX_Q9BRP1
    UniProt: Q9BRP1

  • Chr Location
    19q13.11; chr19:34404399-34426168 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit prenatal lethality, mostly before E12.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    53
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002635 Ensembl Gene Model | MGI Sequence Detail 12163 C57BL/6J ±  kb
transcript ENSMUST00000002710 Ensembl | MGI Sequence Detail 1295 Not Applicable  
polypeptide ENSMUSP00000002710 Ensembl | MGI Sequence Detail 364 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 53
    cDNA 53

    Microarray probesets 4
References
more
  • Summaries
    All 27
    Gene Ontology 2
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:306721 Houston BJ, et al., Programmed Cell Death 2-Like (Pdcd2l) Is Required for Mouse Embryonic Development. G3 (Bethesda). 2020 Dec 3;10(12):4449-4457
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory