Cep70 MGI Mouse Gene Detail - MGI:1915371

Symbol

Cep70
Name

centrosomal protein 70
Synonyms

6720484E09Rik, C030018L16Rik

Feature Type

protein coding gene
IDs

MGI:1915371
NCBI Gene: 68121
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr9:99125420-99182457 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 51.45 cM, cytoband F1
Mapping Data

2 experiments

SNPs within 2kb

1508 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915371	protein coding gene	Chr9:99065640-99205569 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035167	protein coding gene	Chr9:100612872-100665393 (+)
A/J	MGP_AJ_G0035148	protein coding gene	Chr9:97054560-97105376 (+)
AKR/J	MGP_AKRJ_G0035080	protein coding gene	Chr9:99432489-99484357 (+)
BALB/cJ	MGP_BALBcJ_G0035141	protein coding gene	Chr9:96737236-96788693 (+)
C3H/HeJ	MGP_C3HHeJ_G0034851	protein coding gene	Chr9:99819159-99869752 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035661	protein coding gene	Chr9:103495821-103550321 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032560	protein coding gene	Chr9:94800177-94850425 (+)
CAST/EiJ	MGP_CASTEiJ_G0034162	protein coding gene	Chr9:99633724-99687503 (+)
CBA/J	MGP_CBAJ_G0034819	protein coding gene	Chr9:107032643-107083968 (+)
DBA/2J	MGP_DBA2J_G0034981	protein coding gene	Chr9:96571387-96622185 (+)
FVB/NJ	MGP_FVBNJ_G0034929	protein coding gene	Chr9:95388486-95439994 (+)
LP/J	MGP_LPJ_G0035057	protein coding gene	Chr9:100859078-100913740 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034968	protein coding gene	Chr9:108962225-109014924 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035683	protein coding gene	Chr9:99679758-99731362 (+)
PWK/PhJ	MGP_PWKPhJ_G0033869	protein coding gene	Chr9:96786452-96840037 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033704	protein coding gene	Chr9:99746458-99797543 (+)
WSB/EiJ	MGP_WSBEiJ_G0034282	protein coding gene	Chr9:99543646-99598023 (+)

Human Ortholog

CEP70, centrosomal protein 70

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CEP70, centrosomal protein 70
Synonyms

BITE
Links

HGNC:29972

NCBI Gene ID: 80321

neXtProt AC: NX_Q8NHQ1

UniProt: Q8NHQ1
Chr Location

3q22.3; chr3:138494344-138594538 (-) GRCh38

MGI Vertebrate Homology

Cep70 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CEP70
Gene Tree

Cep70

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

87
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

82
Targeted

2
Genomic Mutations

1 involving Cep70
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

84 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit male infertility, azoospermia, teratozoospermia, and abnormal acrosome morphology.

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All GO Annotations

10
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

37

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cep70

ZFIN cep70

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All Sequences

90
RefSeq

37
UniProt

5
CCDS

CCDS40738.1

Ensembl

ENSMUSG00000056267 (Evidence)
NCBI Gene

68121

			Length	Strain/Species	Flank
genomic	ENSMUSG00000056267	Ensembl Gene Model \| MGI Sequence Detail	57038	C57BL/6J	± kb
transcript	ENSMUST00000093795	Ensembl \| MGI Sequence Detail	2606	Not Applicable
polypeptide	ENSMUSP00000091312	Ensembl \| MGI Sequence Detail	616	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005355 centrosomal protein of 70 kDa

(term hierarchy)
InterPro Domains

IPR037692 Centrosomal protein of 70kDa

IPR019734 Tetratricopeptide repeat

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All nucleic 41

Genomic 2

cDNA 39

Microarray probesets 5

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MGI:1924987

Summaries

All 39

Gene Ontology 6

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:333258 Liu Q, et al., Loss of CEP70 function affects acrosome biogenesis and flagella formation during spermiogenesis. Cell Death Dis. 2021 May 12;12(5):478

TSS for Cep70:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86678	Chr9:99125474-99125527 (+)	81 bp
Tssr86679	Chr9:99125736-99125794 (+)	345 bp
Tssr86680	Chr9:99129122-99129128 (+)	3,705 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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