Otub2 MGI Mouse Gene Detail - MGI:1915399 - OTU domain, ubiquitin aldehyde binding 2

Symbol

Otub2
Name

OTU domain, ubiquitin aldehyde binding 2
Synonyms

2010015L18Rik, 4930586I02Rik, OTB2, OTU2

Feature Type

protein coding gene
IDs

MGI:1915399
NCBI Gene: 68149
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr12:103354941-103372609 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 52.92 cM
Mapping Data

2 experiments

SNPs within 2kb

523 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915399	protein coding gene	Chr12:103343244-103372609 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020047	protein coding gene	Chr12:105068072-105085563 (+)
A/J	MGP_AJ_G0020003	protein coding gene	Chr12:101029350-101047004 (+)
AKR/J	MGP_AKRJ_G0019979	protein coding gene	Chr12:103878792-103896457 (+)
BALB/cJ	MGP_BALBcJ_G0019989	protein coding gene	Chr12:101385280-101402945 (+)
C3H/HeJ	MGP_C3HHeJ_G0019791	protein coding gene	Chr12:104371519-104389074 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020438	protein coding gene	Chr12:108332349-108351490 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018051	protein coding gene	Chr12:98070790-98088388 (+)
CAST/EiJ	MGP_CASTEiJ_G0019337	protein coding gene	Chr12:99222746-99242662 (+)
CBA/J	MGP_CBAJ_G0019763	protein coding gene	Chr12:112358991-112378932 (+)
DBA/2J	MGP_DBA2J_G0019874	protein coding gene	Chr12:100551111-100568928 (+)
FVB/NJ	MGP_FVBNJ_G0019863	protein coding gene	Chr12:99285043-99302711 (+)
LP/J	MGP_LPJ_G0019950	protein coding gene	Chr12:104915316-104932773 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019903	protein coding gene	Chr12:115814428-115834307 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020467	protein coding gene	Chr12:103414959-103433468 (+)
PWK/PhJ	MGP_PWKPhJ_G0019100	protein coding gene	Chr12:95112353-95130739 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018896	protein coding gene	Chr12:97616249-97635554 (+)
WSB/EiJ	MGP_WSBEiJ_G0019391	protein coding gene	Chr12:104301923-104319315 (+)

Human Ortholog

OTUB2, OTU deubiquitinase, ubiquitin aldehyde binding 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OTUB2, OTU deubiquitinase, ubiquitin aldehyde binding 2
Synonyms

C14orf137, OTB2, OTU2
Links

HGNC:20351

NCBI Gene ID: 78990

neXtProt AC: NX_Q96DC9

UniProt: Q96DC9
Chr Location

14q32.12; chr14:94026340-94048930 (+) GRCh38

MGI Vertebrate Homology

Otub2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: OTUB2
Protein SuperFamily

Ubiquitin_thioesterase_Otubain
Gene Tree

Otub2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

4
Genomic Mutations

1 involving Otub2
Incidental Mutations

APF
Find Mice (IMSR)

22 strains or lines available

Mice homozygous or heterozygous for a null mutation show increased incidence of chemically induced tumors.

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All GO Annotations

13
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

16

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase otub2

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All Sequences

61
RefSeq

7
UniProt

4
CCDS

CCDS36528.1, CCDS49150.1

Ensembl

ENSMUSG00000021203 (Evidence)
NCBI Gene

68149

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021203	Ensembl Gene Model \| MGI Sequence Detail	17669	C57BL/6J	± kb
transcript	ENSMUST00000101094	Ensembl \| MGI Sequence Detail	3228	Not Applicable
polypeptide	ENSMUSP00000098655	Ensembl \| MGI Sequence Detail	323	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000012081 ubiquitin thioesterase OTUB2

(term hierarchy)
EC

3.4.19.12
InterPro Domains

IPR003323 OTU domain

IPR038765 Papain-like cysteine peptidase superfamily

IPR019400 Peptidase C65, otubain

IPR042468 Peptidase C65, otubain, subdomain 1

IPR042467 Peptidase C65, otubain, subdomain 2

IPR016615 Ubiquitin thioesterase Otubain

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All nucleic 16

cDNA 16

Microarray probesets 6

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MGI:1919646, MGI:2144803, MGI:2145047

Summaries

All 32

Gene Ontology 4

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Otub2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114807	Chr12:103354915-103354982 (+)	8 bp
Tssr114808	Chr12:103354986-103355024 (+)	64 bp
Tssr114809	Chr12:103360137-103360148 (+)	5,202 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24