About   Help   FAQ
Gtf2e2 Gene Detail
Summary
  • Symbol
    Gtf2e2
  • Name
    general transcription factor II E, polypeptide 2 (beta subunit)
  • Synonyms
    34kDa, C330006J08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915403
    NCBI Gene: 68153
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:34221942-34267201 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 20.79 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1005 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915403
 protein coding gene Chr8:34221861-34267201 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033527
 protein coding gene Chr8:32190097-32243566 (+)
A/J MGP_AJ_G0033507
 protein coding gene Chr8:30961293-31006735 (+)
AKR/J MGP_AKRJ_G0033431
 protein coding gene Chr8:31927996-31977502 (+)
BALB/cJ MGP_BALBcJ_G0033503
 protein coding gene Chr8:31082655-31127940 (+)
C3H/HeJ MGP_C3HHeJ_G0033215
 protein coding gene Chr8:32252517-32300409 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034019
 protein coding gene Chr8:33431017-33479182 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030968
 protein coding gene Chr8:27964354-28011220 (+)
CAST/EiJ MGP_CASTEiJ_G0032542
 protein coding gene Chr8:31693013-31742402 (+)
CBA/J MGP_CBAJ_G0033193
 protein coding gene Chr8:34736845-34792298 (+)
DBA/2J MGP_DBA2J_G0033346
 protein coding gene Chr8:30939639-30984712 (+)
FVB/NJ MGP_FVBNJ_G0033291
 protein coding gene Chr8:30603310-30648715 (+)
LP/J MGP_LPJ_G0033436
 protein coding gene Chr8:32156354-32207322 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033333
 protein coding gene Chr8:34271408-34321858 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034038
 protein coding gene Chr8:32018400-32066392 (+)
PWK/PhJ MGP_PWKPhJ_G0032254
 protein coding gene Chr8:30456049-30501622 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032085
 protein coding gene Chr8:31283857-31331531 (+)
WSB/EiJ MGP_WSBEiJ_G0032658
 protein coding gene Chr8:32150401-32201370 (+)



Homology
more
  • Human Ortholog
    GTF2E2, general transcription factor IIE subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GTF2E2, general transcription factor IIE subunit 2
  • Synonyms
    FE, TF2E2, TFIIE-B, TTD6
  • Links
    NCBI Gene ID: 2961
    neXtProt AC: NX_P29084
    UniProt: P29084

  • Chr Location
    8p12; chr8:30578318-30658236 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GTF2E2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    786
  • Tissues
    22
  • cDNA Data
    15
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68153 NCBI Gene Model | MGI Sequence Detail 45260 C57BL/6J ±  kb
    transcript NM_001167922 RefSeq | MGI Sequence Detail 1664 C57BL/6  
    polypeptide Q9D902 UniProt | EBI | MGI Sequence Detail 292 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000029777 transcription initiation factor IIE subunit beta
      (term hierarchy)
    • InterPro Domains
      IPR040501 TFA2, Winged helix domain 2
      IPR003166 Transcription factor TFIIE beta subunit, DNA-binding domain
      IPR016656 Transcription initiation factor TFIIE, beta subunit
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142560
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:61657 De Graeve F, et al., A murine ATFa-associated factor with transcriptional repressing activity. Oncogene. 2000 Mar 30;19(14):1807-19
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory