Spire1 MGI Mouse Gene Detail - MGI:1915416 - spire type actin nucleation factor 1

Symbol

Spire1
Name

spire type actin nucleation factor 1
Synonyms

6030430B19Rik, Spir-1

Feature Type

protein coding gene
IDs

MGI:1915416
NCBI Gene: 68166
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr18:67621279-67743860 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 39.99 cM
Mapping Data

2 experiments

SNPs within 2kb

3884 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915416	protein coding gene	Chr18:67621279-67745880 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024526	protein coding gene	Chr18:67779293-67916068 (-)
A/J	MGP_AJ_G0024493	protein coding gene	Chr18:64821965-64948430 (-)
AKR/J	MGP_AKRJ_G0024463	protein coding gene	Chr18:66722905-66855095 (-)
BALB/cJ	MGP_BALBcJ_G0024492	protein coding gene	Chr18:64991653-65115705 (-)
C3H/HeJ	MGP_C3HHeJ_G0024260	protein coding gene	Chr18:66874811-67007569 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024939	protein coding gene	Chr18:69567181-69696508 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022370	protein coding gene	Chr18:64194313-64322144 (-)
CAST/EiJ	MGP_CASTEiJ_G0023733	protein coding gene	Chr18:66875346-67004542 (-)
CBA/J	MGP_CBAJ_G0024230	protein coding gene	Chr18:71972009-72110451 (-)
DBA/2J	MGP_DBA2J_G0024360	protein coding gene	Chr18:64474895-64597936 (-)
FVB/NJ	MGP_FVBNJ_G0024326	protein coding gene	Chr18:63846386-63969341 (-)
LP/J	MGP_LPJ_G0024444	protein coding gene	Chr18:67642748-67775895 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024355	protein coding gene	Chr18:73241131-73378300 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024986	protein coding gene	Chr18:66890287-67017537 (-)
PWK/PhJ	MGP_PWKPhJ_G0023476	protein coding gene	Chr18:64748992-64879177 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023281	protein coding gene	Chr18:67051468-67182808 (-)
WSB/EiJ	MGP_WSBEiJ_G0023797	protein coding gene	Chr18:66797835-66928311 (-)

Human Ortholog

SPIRE1, spire type actin nucleation factor 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPIRE1, spire type actin nucleation factor 1
Synonyms

Spir-1
Links

HGNC:30622

NCBI Gene ID: 56907

neXtProt AC: NX_Q08AE8

UniProt: Q08AE8
Chr Location

18p11.21; chr18:12446512-12662091 (-) GRCh38

MGI Vertebrate Homology

Spire1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SPIRE1
Gene Tree

Spire1

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Phenotype Summary

10 phenotypes from 1 allele in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

28
Endonuclease-mediated

2
Gene trapped

24
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

55 strains or lines available

Mice homozygous for a knock-out allele are viable and fertile with normal brain anatomy and intact visual and motor functions in both sexes, but show a male-specific increase in contextual and cued fear memory.

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All GO Annotations

37
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

766
Tissues

38
cDNA Data

121
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase spire1

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All Sequences

95
RefSeq

25
UniProt

6
CCDS

CCDS29323.1, CCDS37849.1

Ensembl

ENSMUSG00000024533 (Evidence)
NCBI Gene

68166

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024533	Ensembl Gene Model \| MGI Sequence Detail	122582	C57BL/6J	± kb
transcript	ENSMUST00000115050	Ensembl \| MGI Sequence Detail	5405	Not Applicable
polypeptide	ENSMUSP00000110702	Ensembl \| MGI Sequence Detail	743	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000015546 protein spire homolog 1

(term hierarchy)
InterPro Domains

IPR011019 KIND domain

IPR029901 Protein Spire

IPR029905 Protein Spire homolog 1, FYVE-related domain

IPR011011 Zinc finger, FYVE/PHD-type

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All nucleic 123

cDNA 121

Primer pair 2

Microarray probesets 6

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MGI:2147220, MGI:2147317, MGI:2147372

Summaries

All 41

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 7
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:304537 Scheffler K, et al., Two mechanisms drive pronuclear migration in mouse zygotes. Nat Commun. 2021 Feb 5;12(1):841

TSS for Spire1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr153782	Chr18:67743928-67743985 (-)	-97 bp
Tssr153781	Chr18:67743892-67743922 (-)	-47 bp
Tssr153780	Chr18:67743872-67743878 (-)	-15 bp
Tssr5361	Chr18:67743854-67743870 (-)	-2 bp
Tssr153779	Chr18:67743831-67743840 (-)	24 bp
Tssr153778	Chr18:67743803-67743804 (-)	56 bp
Tssr153777	Chr18:67734484-67734491 (-)	9,372 bp
Tssr153776	Chr18:67688379-67688385 (-)	55,478 bp
Tssr153775	Chr18:67682314-67682339 (-)	61,533 bp
Tssr153774	Chr18:67641656-67641659 (-)	102,202 bp
Tssr153773	Chr18:67635667-67635671 (-)	108,191 bp
Tssr153772	Chr18:67622486-67622491 (-)	121,371 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24