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Iftap Gene Detail
Summary
  • Symbol
    Iftap
  • Name
    intraflagellar transport associated protein
  • Synonyms
    B230118H07Rik, NWC
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915420
    NCBI Gene: 68170
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:101391124-101459376 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 53.83 cM, cytoband E2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1702 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915420
 protein coding gene Chr2:101391124-101479877 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026188
 protein coding gene Chr2:103430340-103520197 (-)
A/J MGP_AJ_G0026149
 protein coding gene Chr2:99156760-99247961 (-)
AKR/J MGP_AKRJ_G0026130
 protein coding gene Chr2:101856653-101950512 (-)
BALB/cJ MGP_BALBcJ_G0026158
 protein coding gene Chr2:99464576-99552092 (-)
C3H/HeJ MGP_C3HHeJ_G0025909
 protein coding gene Chr2:102224267-102317135 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026609
 protein coding gene Chr2:106931983-107025419 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024000
 protein coding gene Chr2:94863476-94953466 (-)
CAST/EiJ MGP_CASTEiJ_G0025374
 protein coding gene Chr2:102640353-102734295 (-)
CBA/J MGP_CBAJ_G0025887
 protein coding gene Chr2:110611862-110715648 (-)
DBA/2J MGP_DBA2J_G0026023
 protein coding gene Chr2:98743486-98831651 (-)
FVB/NJ MGP_FVBNJ_G0025986
 protein coding gene Chr2:97746582-97833677 (-)
LP/J MGP_LPJ_G0026127
 protein coding gene Chr2:103590299-103679891 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026012
 protein coding gene Chr2:114601570-114694055 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026663
 protein coding gene Chr2:102077805-102167866 (-)
PWK/PhJ MGP_PWKPhJ_G0025109
 protein coding gene Chr2:98212794-98307033 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024910
 protein coding gene Chr2:101278801-101377312 (-)
WSB/EiJ MGP_WSBEiJ_G0025441
 protein coding gene Chr2:102772053-102867685 (-)



Homology
more
  • Human Ortholog
    IFTAP, intraflagellar transport associated protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFTAP, intraflagellar transport associated protein
  • Synonyms
    C11orf74, HEPIS, NWC
  • Links
    NCBI Gene ID: 119710
    neXtProt AC: NX_Q86VG3
    UniProt: Q86VG3

  • Chr Location
    11p12; chr11:36594369-36675695 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are overtly normal and fertile under standard laboratory conditions. Under non-standard mating conditions, males show reduced sperm competitiveness, sperm head abnormalities, and reduced sperm ability to fertilize cumulus-intact eggs in vitro.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    8
  • cDNA Data
    57
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68170 NCBI Gene Model | MGI Sequence Detail 68253 C57BL/6J ±  kb
    transcript NM_001362688 RefSeq | MGI Sequence Detail 2407 C57BL/6  
    polypeptide Q9CQI4 UniProt | EBI | MGI Sequence Detail 244 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      cDNA 59

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:6390552
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory