Denr MGI Mouse Gene Detail - MGI:1915434 - density-regulated protein

Symbol

Denr
Name

density-regulated protein
Synonyms

1500003K04Rik

Feature Type

protein coding gene
IDs

MGI:1915434
NCBI Gene: 68184
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr5:124045309-124066705 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 63.26 cM, cytoband F
Mapping Data

2 experiments

SNPs within 2kb

550 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915434	protein coding gene	Chr5:124045238-124066898 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030082	protein coding gene	Chr5:127680890-127703619 (+)
A/J	MGP_AJ_G0030047	protein coding gene	Chr5:122376435-122397448 (+)
AKR/J	MGP_AKRJ_G0029983	protein coding gene	Chr5:126313857-126336864 (+)
BALB/cJ	MGP_BALBcJ_G0030058	protein coding gene	Chr5:123705085-123726463 (+)
C3H/HeJ	MGP_C3HHeJ_G0029775	protein coding gene	Chr5:126926029-126947681 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030511	protein coding gene	Chr5:132627668-132649322 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027737	protein coding gene	Chr5:116916057-116936554 (+)
CAST/EiJ	MGP_CASTEiJ_G0029184	protein coding gene	Chr5:126035010-126061013 (+)
CBA/J	MGP_CBAJ_G0029745	protein coding gene	Chr5:137827553-137850672 (+)
DBA/2J	MGP_DBA2J_G0029895	protein coding gene	Chr5:122396842-122418739 (+)
FVB/NJ	MGP_FVBNJ_G0029851	protein coding gene	Chr5:121426508-121448379 (+)
LP/J	MGP_LPJ_G0029984	protein coding gene	Chr5:128219478-128242794 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029882	protein coding gene	Chr5:141441528-141463872 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030552	protein coding gene	Chr5:125921967-125943714 (+)
PWK/PhJ	MGP_PWKPhJ_G0028898	protein coding gene	Chr5:121207572-121229952 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028735	protein coding gene	Chr5:123586514-123613707 (+)
WSB/EiJ	MGP_WSBEiJ_G0029259	protein coding gene	Chr5:126608183-126631873 (+)

Human Ortholog

DENR, density regulated re-initiation and release factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DENR, density regulated re-initiation and release factor
Synonyms

DRP, DRP1, SMAP-3
Links

HGNC:2769

NCBI Gene ID: 8562

neXtProt AC: NX_O43583

UniProt: O43583
Chr Location

12q24.31; chr12:122752824-122771064 (+) GRCh38

MGI Vertebrate Homology

Denr stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DENR
Gene Tree

Denr

less

Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

36
Chemically induced (other)

1
Gene trapped

31
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Denr
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit abnormalities in trophoblast layer formation and trophoblast giant cell size and morphology and complete embryonic lethality during organogenesis.

less

All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

2
cDNA Data

71
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA DENR

Xenbase denr

ZFIN denr

less

All Sequences

49
RefSeq

12
UniProt

2
CCDS

CCDS39275.1

Ensembl

ENSMUSG00000023106 (Evidence)
NCBI Gene

68184

			Length	Strain/Species	Flank
genomic	68184	NCBI Gene Model \| MGI Sequence Detail	21397	C57BL/6J	± kb
transcript	NM_001417691	RefSeq \| MGI Sequence Detail	2234	C57BL/6
polypeptide	Q9CQJ6	UniProt \| EBI \| MGI Sequence Detail	198	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000006420 density-regulated protein

(term hierarchy)
InterPro Domains

IPR046447 DENR, C-terminal domain

IPR005873 DENR, eukaryotes

IPR048517 DENR, N-terminal domain

IPR050318 DENR/SUI1 Translation Initiation Factor

IPR001950 SUI1 domain

IPR036877 SUI1 domain superfamily

less

All nucleic 74

cDNA 72

Primer pair 1

Other 1

Microarray probesets 3

Summaries

All 46

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 21
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Denr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48807	Chr5:124045249-124045260 (+)	-54 bp
Tssr48808	Chr5:124045262-124045273 (+)	-41 bp
Tssr48809	Chr5:124045302-124045355 (+)	20 bp
Tssr48810	Chr5:124045357-124045378 (+)	59 bp
Tssr48811	Chr5:124045439-124045450 (+)	136 bp
Tssr48812	Chr5:124045585-124045623 (+)	295 bp
Tssr48813	Chr5:124045625-124045634 (+)	321 bp
Tssr48814	Chr5:124045635-124045650 (+)	334 bp
Tssr48815	Chr5:124045659-124045670 (+)	356 bp
Tssr48816	Chr5:124045685-124045696 (+)	382 bp
Tssr48817	Chr5:124046145-124046177 (+)	852 bp
Tssr48818	Chr5:124046241-124046251 (+)	937 bp
Tssr48819	Chr5:124047153-124047171 (+)	1,853 bp
Tssr48820	Chr5:124047187-124047196 (+)	1,883 bp
Tssr48821	Chr5:124053049-124053055 (+)	7,743 bp
Tssr48822	Chr5:124053156-124053170 (+)	7,854 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24