Hsbp1 MGI Mouse Gene Detail - MGI:1915446 - heat shock factor binding protein 1

Symbol

Hsbp1
Name

heat shock factor binding protein 1
Synonyms

0610007A03Rik

Feature Type

protein coding gene
IDs

MGI:1915446
NCBI Gene: 68196
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr8:120071277-120075668 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 67.54 cM
Mapping Data

2 experiments

SNPs within 2kb

207 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915446	protein coding gene	Chr8:120071227-120075668 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034179	protein coding gene	Chr8:122643031-122649476 (+)
A/J	MGP_AJ_G0034159	protein coding gene	Chr8:117606660-117611051 (+)
AKR/J	MGP_AKRJ_G0034086	protein coding gene	Chr8:121026430-121030812 (+)
BALB/cJ	MGP_BALBcJ_G0034153	protein coding gene	Chr8:117816860-117821295 (+)
C3H/HeJ	MGP_C3HHeJ_G0033864	protein coding gene	Chr8:121749380-121753576 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034673	protein coding gene	Chr8:126750447-126754825 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031615	protein coding gene	Chr8:110504402-110508758 (+)
CAST/EiJ	MGP_CASTEiJ_G0033191	protein coding gene	Chr8:121684056-121690626 (+)
CBA/J	MGP_CBAJ_G0033837	protein coding gene	Chr8:131371944-131381480 (+)
DBA/2J	MGP_DBA2J_G0033993	protein coding gene	Chr8:116833390-116837776 (+)
FVB/NJ	MGP_FVBNJ_G0033936	protein coding gene	Chr8:115848542-115852933 (+)
LP/J	MGP_LPJ_G0034082	protein coding gene	Chr8:122797375-122801763 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033983	protein coding gene	Chr8:133830734-133835075 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034691	protein coding gene	Chr8:121174653-121179373 (+)
PWK/PhJ	MGP_PWKPhJ_G0032893	protein coding gene	Chr8:116586184-116590598 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032733	protein coding gene	Chr8:119865201-119870910 (+)
WSB/EiJ	MGP_WSBEiJ_G0033307	protein coding gene	Chr8:121890107-121894491 (+)

Human Ortholog

HSBP1, heat shock factor binding protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSBP1, heat shock factor binding protein 1
Synonyms

NPC-A-13
Links

HGNC:5203

NCBI Gene ID: 3281

neXtProt AC: NX_O75506

UniProt: O75506
Chr Location

16q23.3; chr16:83719311-83819737 (+) GRCh38

MGI Vertebrate Homology

Hsbp1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: HSBP1
Gene Tree

Hsbp1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Gene trapped

3
Targeted

3
Find Mice (IMSR)

8 strains or lines available

Homozygous null mice die at the perimplantation stage and embryoid bodies show disorganized germ layers and endoderm development abnormaliies.

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All GO Annotations

13
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

15
cDNA Data

242
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HSBP1

Xenbase hsbp1

ZFIN hsbp1a, hsbp1b

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All Sequences

36
RefSeq

2
UniProt

1
CCDS

CCDS40492.1

Ensembl

ENSMUSG00000031839 (Evidence)
NCBI Gene

68196

			Length	Strain/Species	Flank
genomic	68196	NCBI Gene Model \| MGI Sequence Detail	4392	C57BL/6J	± kb
transcript	NM_024219	RefSeq \| MGI Sequence Detail	1178	C57BL/6
polypeptide	Q9CQZ1	UniProt \| EBI \| MGI Sequence Detail	76	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008768 heat shock factor-binding protein 1

(term hierarchy)
InterPro Domains

IPR009643 Heat shock factor binding 1

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All nucleic 244

cDNA 243

Other 1

Microarray probesets 3

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MGI:2142406

Summaries

All 36

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:267025 Jung H, et al., Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice. Nat Neurosci. 2018 Sep;21(9):1218-1228

TSS for Hsbp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79672	Chr8:120071211-120071222 (+)	-60 bp
Tssr79673	Chr8:120071229-120071275 (+)	-25 bp
Tssr79674	Chr8:120071279-120071290 (+)	8 bp
Tssr79675	Chr8:120071456-120071470 (+)	186 bp
Tssr79676	Chr8:120071488-120071500 (+)	217 bp
Tssr79677	Chr8:120071671-120071712 (+)	415 bp
Tssr79678	Chr8:120071978-120071999 (+)	712 bp
Tssr79679	Chr8:120072164-120072174 (+)	892 bp
Tssr79680	Chr8:120072360-120072371 (+)	1,089 bp
Tssr79681	Chr8:120074863-120074928 (+)	3,619 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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