Gsto2 MGI Mouse Gene Detail - MGI:1915464 - glutathione S-transferase omega 2

Symbol

Gsto2
Name

glutathione S-transferase omega 2
Synonyms

1700020F09Rik, 4930425C18Rik

Feature Type

protein coding gene
IDs

MGI:1915464
NCBI Gene: 68214
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr19:47853973-47874763 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 40.41 cM, cytoband D2
Mapping Data

2 experiments

SNPs within 2kb

752 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915464	protein coding gene	Chr19:47853879-47874763 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025236	protein coding gene	Chr19:47727868-47748815 (+)
A/J	MGP_AJ_G0025212	protein coding gene	Chr19:45325278-45345997 (+)
AKR/J	MGP_AKRJ_G0025181	protein coding gene	Chr19:46793968-46814740 (+)
BALB/cJ	MGP_BALBcJ_G0025207	protein coding gene	Chr19:45381493-45402238 (+)
C3H/HeJ	MGP_C3HHeJ_G0024967	protein coding gene	Chr19:46970560-46991330 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025650	protein coding gene	Chr19:48843967-48867697 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023063	protein coding gene	Chr19:44531434-44551203 (+)
CAST/EiJ	MGP_CASTEiJ_G0024432	protein coding gene	Chr19:46788574-46811173 (+)
CBA/J	MGP_CBAJ_G0024947	protein coding gene	Chr19:51323200-51344059 (+)
DBA/2J	MGP_DBA2J_G0025079	protein coding gene	Chr19:45143543-45164323 (+)
FVB/NJ	MGP_FVBNJ_G0025040	protein coding gene	Chr19:44915227-44936319 (+)
LP/J	MGP_LPJ_G0025165	protein coding gene	Chr19:47609597-47633066 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025071	protein coding gene	Chr19:50553172-50571561 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025708	protein coding gene	Chr19:46920805-46941561 (+)
PWK/PhJ	MGP_PWKPhJ_G0024181	protein coding gene	Chr19:45098272-45119408 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023984	protein coding gene	Chr19:45576560-45597221 (+)
WSB/EiJ	MGP_WSBEiJ_G0024502	protein coding gene	Chr19:47069265-47090877 (+)

Human Ortholog

GSTO2, glutathione S-transferase omega 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GSTO2, glutathione S-transferase omega 2
Synonyms

bA127L20.1, GSTO 2-2
Links

HGNC:23064

NCBI Gene ID: 119391

neXtProt AC: NX_Q9H4Y5

UniProt: Q9H4Y5
Chr Location

10q25.1; chr10:104268873-104304950 (+) GRCh38

MGI Vertebrate Homology

Gsto2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GSTO2
Gene Tree

Gsto2

Diseases

3 with human GSTO2 associations

				Human Disease	Mouse Models
				Alzheimer's disease IDs Alzheimer's disease DOID:10652 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 UMLS_CUI:C0002395
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				Parkinson's disease IDs Parkinson's disease DOID:14330 ICD10CM:G20 ICD9CM:332 ICD9CM:332.0 KEGG:05012 MESH:D010300 NCI:C26845 OMIM:PS168600 ORDO:2828 UMLS_CUI:C0030567

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Targeted

3
Incidental Mutations

APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

22
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

20
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gsto2

ZFIN gsto2

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All Sequences

60
RefSeq

12
UniProt

7
CCDS

CCDS29894.1

Ensembl

ENSMUSG00000025069 (Evidence)
NCBI Gene

68214

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025069	Ensembl Gene Model \| MGI Sequence Detail	20791	C57BL/6J	± kb
transcript	ENSMUST00000120645	Ensembl \| MGI Sequence Detail	1277	Not Applicable
polypeptide	ENSMUSP00000113409	Ensembl \| MGI Sequence Detail	248	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000008304 glutathione S-transferase omega-2

(term hierarchy)
EC

1.20.4.2, 1.8.5.1, 2.5.1.18
InterPro Domains

IPR036282 Glutathione S-transferase, C-terminal domain superfamily

IPR010987 Glutathione S-transferase, C-terminal-like

IPR004045 Glutathione S-transferase, N-terminal

IPR005442 Glutathione S-transferase, omega-class

IPR050983 Glutathione S-transferase Omega/HSP26

IPR040079 Glutathione transferase family

IPR036249 Thioredoxin-like superfamily

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All nucleic 21

cDNA 20

Primer pair 1

Microarray probesets 2

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MGI:1925405

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gsto2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156902	Chr19:47852730-47852745 (+)	-1,235 bp
Tssr156903	Chr19:47852755-47852764 (+)	-1,213 bp
Tssr156904	Chr19:47852784-47852789 (+)	-1,186 bp
Tssr156905	Chr19:47852827-47852842 (+)	-1,138 bp
Tssr156906	Chr19:47852860-47852869 (+)	-1,108 bp
Tssr156907	Chr19:47852879-47852927 (+)	-1,070 bp
Tssr156908	Chr19:47852947-47852956 (+)	-1,021 bp
Tssr156909	Chr19:47852973-47852980 (+)	-996 bp
Tssr156910	Chr19:47853002-47853025 (+)	-959 bp
Tssr156911	Chr19:47853055-47853077 (+)	-907 bp
Tssr156912	Chr19:47853079-47853095 (+)	-886 bp
Tssr156913	Chr19:47853147-47853156 (+)	-821 bp
Tssr156914	Chr19:47853955-47853968 (+)	-11 bp
Tssr156915	Chr19:47853982-47853987 (+)	12 bp
Tssr156916	Chr19:47854012-47854020 (+)	43 bp
Tssr156917	Chr19:47854216-47854247 (+)	259 bp
Tssr156918	Chr19:47854254-47854274 (+)	291 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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