Fam111a MGI Mouse Gene Detail - MGI:1915508 - family with sequence similarity 111, member A

Symbol

Fam111a
Name

family with sequence similarity 111, member A
Synonyms

4632417K18Rik

Feature Type

protein coding gene
IDs

MGI:1915508
NCBI Gene: 107373
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr19:12550874-12567133 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 8.72 cM, cytoband B
Mapping Data

3 experiments

SNPs within 2kb

461 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915508	protein coding gene	Chr19:12523104-12567133 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024907	protein coding gene	Chr19:10041510-10063044 (+)
A/J	MGP_AJ_G0024883	protein coding gene	Chr19:9404130-9422123 (+)
AKR/J	MGP_AKRJ_G0024855	protein coding gene	Chr19:9873561-9896957 (+)
BALB/cJ	MGP_BALBcJ_G0024882	protein coding gene	Chr19:9405972-9424168 (+)
C3H/HeJ	MGP_C3HHeJ_G0024646	protein coding gene	Chr19:9759608-9782389 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025331	protein coding gene	Chr19:10590812-10613945 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022757	protein coding gene	Chr19:10029600-10050714 (+)
CAST/EiJ	MGP_CASTEiJ_G0024115	protein coding gene	Chr19:9327038-9346282 (+)
CBA/J	MGP_CBAJ_G0024620	protein coding gene	Chr19:10670386-10693822 (+)
DBA/2J	MGP_DBA2J_G0024752	protein coding gene	Chr19:9456488-9478099 (+)
FVB/NJ	MGP_FVBNJ_G0024715	protein coding gene	Chr19:9468374-9486357 (+)
LP/J	MGP_LPJ_G0024835	protein coding gene	Chr19:10118985-10141327 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024742	protein coding gene	Chr19:10451500-10469510 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025379	protein coding gene	Chr19:9852783-9874312 (+)
PWK/PhJ	MGP_PWKPhJ_G0023864	protein coding gene	Chr19:8909896-8927986 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023668	protein coding gene	Chr19:8988521-9025771 (+)
WSB/EiJ	MGP_WSBEiJ_G0024183	protein coding gene	Chr19:9709112-9731761 (+)

Human Ortholog

FAM111A, FAM111 trypsin like peptidase A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM111A, FAM111 trypsin like peptidase A
Synonyms

GCLEB, KCS2
Links

HGNC:24725

NCBI Gene ID: 63901

neXtProt AC: NX_Q96PZ2

UniProt: Q96PZ2
Chr Location

11q12.1; chr11:59142748-59155039 (+) GRCh38

MGI Vertebrate Homology

Fam111a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FAM111A
Gene Tree

Fam111a

Diseases

1 with human FAM111A associations

				Human Disease	Mouse Models
				Kenny-Caffey syndrome type 2 IDs Kenny-Caffey syndrome type 2 DOID:0080723 OMIM:127000 ORDO:93325

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
9 phenotype references

All Mutations and Alleles

14
Endonuclease-mediated

2
Gene trapped

9
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available

Mice homozygous for a null allele exhibit normal electrolyte homeostasis and bone phenotype.

less

All GO Annotations

27
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

807
Tissues

10
cDNA Data

71
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

46
RefSeq

4
UniProt

3
CCDS

CCDS29632.1, CCDS84424.1

Ensembl

ENSMUSG00000024691 (Evidence)
NCBI Gene

107373

			Length	Strain/Species	Flank
genomic	107373	NCBI Gene Model \| MGI Sequence Detail	16260	C57BL/6J	± kb
transcript	NM_026640	RefSeq \| MGI Sequence Detail	3199	C57BL/6
polypeptide	Q9D2L9	UniProt \| EBI \| MGI Sequence Detail	613	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000030417 serine protease FAM111A

(term hierarchy)
EC

3.4.21.-
InterPro Domains

IPR009003 Peptidase S1, PA clan

IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold

less

All nucleic 71

cDNA 71

Microarray probesets 6

less

MGI:2147729

Summaries

All 34

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326490 Ilenwabor BP, et al., FAM111A is dispensable for electrolyte homeostasis in mice. Sci Rep. 2022 Jun 17;12(1):10211

TSS for Fam111a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155337	Chr19:12550872-12550906 (+)	15 bp
Tssr155338	Chr19:12551761-12551766 (+)	890 bp
Tssr155339	Chr19:12563228-12563232 (+)	12,356 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24