Slc25a22 MGI Mouse Gene Detail - MGI:1915517 - solute carrier family 25 (mitochondrial carrier, glutamate), member 22

Symbol

Slc25a22
Name

solute carrier family 25 (mitochondrial carrier, glutamate), member 22
Synonyms

1300006L01Rik

Feature Type

protein coding gene
IDs

MGI:1915517
NCBI Gene: 68267
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr7:141009662-141017787 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 86.78 cM
Mapping Data

2 experiments

SNPs within 2kb

181 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915517	protein coding gene	Chr7:141009657-141017805 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033229	protein coding gene	Chr7:146618388-146626536 (-)
A/J	MGP_AJ_G0033211	protein coding gene	Chr7:142423653-142431801 (-)
AKR/J	MGP_AKRJ_G0033143	protein coding gene	Chr7:146373824-146381972 (-)
BALB/cJ	MGP_BALBcJ_G0033212	protein coding gene	Chr7:142168840-142176988 (-)
C3H/HeJ	MGP_C3HHeJ_G0032926	protein coding gene	Chr7:146114031-146122179 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033723	protein coding gene	Chr7:151969748-151977896 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030696	protein coding gene	Chr7:143635797-143643897 (-)
CAST/EiJ	MGP_CASTEiJ_G0032256	protein coding gene	Chr7:138426020-138434163 (-)
CBA/J	MGP_CBAJ_G0032898	protein coding gene	Chr7:157134085-157142231 (-)
DBA/2J	MGP_DBA2J_G0033050	protein coding gene	Chr7:140372054-140380202 (-)
FVB/NJ	MGP_FVBNJ_G0033003	protein coding gene	Chr7:140286421-140294805 (-)
LP/J	MGP_LPJ_G0033145	protein coding gene	Chr7:148114421-148122569 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033036	protein coding gene	Chr7:157764944-157773092 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033743	protein coding gene	Chr7:145332352-145340500 (-)
PWK/PhJ	MGP_PWKPhJ_G0031960	protein coding gene	Chr7:133656229-133664371 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031807	protein coding gene	Chr7:132169266-132177405 (-)
WSB/EiJ	MGP_WSBEiJ_G0032367	protein coding gene	Chr7:146282895-146291078 (-)

Human Ortholog

SLC25A22, solute carrier family 25 member 22

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC25A22, solute carrier family 25 member 22
Synonyms

DEE3, EIEE3, GC-1, GC1, NET44
Links

HGNC:19954

NCBI Gene ID: 79751

neXtProt AC: NX_Q9H936

UniProt: Q9H936
Chr Location

11p15.5; chr11:790475-798281 (-) GRCh38

MGI Vertebrate Homology

Slc25a22 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SLC25A22
Gene Tree

Slc25a22

Diseases

1 with human SLC25A22 associations

				Human Disease	Mouse Models
				developmental and epileptic encephalopathy 3 IDs developmental and epileptic encephalopathy 3 DOID:0080440 OMIM:609304

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

12 phenotype references

All Mutations and Alleles

14
Endonuclease-mediated

3
Gene trapped

7
Radiation induced

1
Targeted

3
Genomic Mutations

1 involving Slc25a22
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available

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All GO Annotations

22
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

874
Tissues

111
cDNA Data

108
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc25a22

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All Sequences

108
RefSeq

14
UniProt

15
CCDS

CCDS22013.1

Ensembl

ENSMUSG00000019082 (Evidence)
NCBI Gene

68267

			Length	Strain/Species	Flank
genomic	68267	NCBI Gene Model \| MGI Sequence Detail	8126	C57BL/6J	± kb
transcript	NM_001360724	RefSeq \| MGI Sequence Detail	2807	C57BL/6
polypeptide	Q9D6M3	UniProt \| EBI \| MGI Sequence Detail	323	Not Applicable

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UniProt

15 Sequences
Protein Ontology

PR:000015018 mitochondrial glutamate carrier 1

(term hierarchy)
InterPro Domains

IPR023395 Mitochondrial carrier domain superfamily

IPR002067 Mitochondrial carrier protein

IPR051028 Mitochondrial Solute Carrier

IPR018108 Mitochondrial substrate/solute carrier
GlyGen

Q9D6M3 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 108

cDNA 108

Microarray probesets 3

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MGI:2141864

Summaries

All 47

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 12
Earliest

J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Slc25a22:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr75657	Chr7:141017742-141017766 (-)	33 bp
Tssr75656	Chr7:141017709-141017718 (-)	73 bp
Tssr75655	Chr7:141017500-141017563 (-)	255 bp
Tssr75654	Chr7:141015240-141015288 (-)	2,523 bp
Tssr75653	Chr7:141014445-141014518 (-)	3,305 bp
Tssr75652	Chr7:141014383-141014399 (-)	3,396 bp
Tssr75651	Chr7:141014192-141014212 (-)	3,585 bp
Tssr75650	Chr7:141014142-141014153 (-)	3,639 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24