Ncapd2 MGI Mouse Gene Detail - MGI:1915548 - non-SMC condensin I complex, subunit D2

Symbol

Ncapd2
Name

non-SMC condensin I complex, subunit D2
Synonyms

2810406C15Rik, 2810465G24Rik, CAP-D2, CNAP1, mKIAA0159

Feature Type

protein coding gene
IDs

MGI:1915548
NCBI Gene: 68298
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr6:125144970-125168664 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 59.32 cM, cytoband F2
Mapping Data

3 experiments

SNPs within 2kb

785 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915548	protein coding gene	Chr6:125144970-125169062 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031289	protein coding gene	Chr6:128500804-128526469 (-)
A/J	MGP_AJ_G0031259	protein coding gene	Chr6:123652962-123676793 (-)
AKR/J	MGP_AKRJ_G0031187	protein coding gene	Chr6:127028600-127053741 (-)
BALB/cJ	MGP_BALBcJ_G0031267	protein coding gene	Chr6:123251220-123275256 (-)
C3H/HeJ	MGP_C3HHeJ_G0030990	protein coding gene	Chr6:127102133-127125631 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031723	protein coding gene	Chr6:131882299-131907810 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028872	protein coding gene	Chr6:120858948-120882512 (-)
CAST/EiJ	MGP_CASTEiJ_G0030371	protein coding gene	Chr6:127303359-127327192 (-)
CBA/J	MGP_CBAJ_G0030951	protein coding gene	Chr6:136940659-136966926 (-)
DBA/2J	MGP_DBA2J_G0031107	protein coding gene	Chr6:122584475-122608839 (-)
FVB/NJ	MGP_FVBNJ_G0031057	protein coding gene	Chr6:121498016-121521606 (-)
LP/J	MGP_LPJ_G0031187	protein coding gene	Chr6:128665029-128689802 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031095	protein coding gene	Chr6:140971356-140998548 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031758	protein coding gene	Chr6:126931087-126955233 (-)
PWK/PhJ	MGP_PWKPhJ_G0030086	protein coding gene	Chr6:120827089-120851353 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029915	protein coding gene	Chr6:125007464-125031246 (-)
WSB/EiJ	MGP_WSBEiJ_G0030456	protein coding gene	Chr6:127300614-127326638 (-)

Human Ortholog

NCAPD2, non-SMC condensin I complex subunit D2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NCAPD2, non-SMC condensin I complex subunit D2
Synonyms

CAP-D2, CNAP1, hCAP-D2, MCPH21
Links

HGNC:24305

NCBI Gene ID: 9918

neXtProt AC: NX_Q15021

UniProt: Q15021
Chr Location

12p13.31; chr12:6493356-6531955 (+) GRCh38

MGI Vertebrate Homology

Ncapd2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NCAPD2
Protein SuperFamily

Condensin_D2
Gene Tree

Ncapd2

Diseases

1 with human NCAPD2 associations

				Human Disease	Mouse Models
				primary autosomal recessive microcephaly IDs primary autosomal recessive microcephaly DOID:0070296 OMIM:PS251200 ORDO:2512

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

4
Gene trapped

13
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

64 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice heterozygous for a null allele exhibit decreased susceptibility to AOM/DSS-induced colorectal cancer and colitis.

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All GO Annotations

26
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

723
Tissues

13
cDNA Data

373
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ncapd2

ZFIN ncapd2

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All Sequences

68
RefSeq

9
UniProt

4
CCDS

CCDS39636.1

Ensembl

ENSMUSG00000038252 (Evidence)
NCBI Gene

68298

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038252	Ensembl Gene Model \| MGI Sequence Detail	23695	C57BL/6J	± kb
transcript	ENSMUST00000043848	Ensembl \| MGI Sequence Detail	4629	Not Applicable
polypeptide	ENSMUSP00000042260	Ensembl \| MGI Sequence Detail	1392	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000011020 condensin complex subunit 1

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR032682 Condensin complex subunit 1, C-terminal

IPR024324 Condensin complex subunit 1, N-terminal

IPR007673 Condensin subunit 1

IPR026971 Condensin subunit 1/Condensin-2 complex subunit D3

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All nucleic 375

cDNA 374

Primer pair 1

Microarray probesets 4

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MGI:1920064

Summaries

All 50

Developmental Gene Expression 5

Gene Ontology 11

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ncapd2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr63259	Chr6:125169059-125169080 (-)	-406 bp
Tssr2016	Chr6:125168637-125168641 (-)	25 bp
Tssr63258	Chr6:125168584-125168626 (-)	59 bp
Tssr63257	Chr6:125168498-125168583 (-)	123 bp
Tssr63256	Chr6:125168461-125168474 (-)	196 bp
Tssr63253	Chr6:125149018-125149027 (-)	19,641 bp
Tssr63252	Chr6:125147750-125147787 (-)	20,895 bp
Tssr63251	Chr6:125145949-125145963 (-)	22,708 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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