Lrriq4 MGI Mouse Gene Detail - MGI:1915557 - leucine-rich repeats and IQ motif containing 4

Symbol

Lrriq4
Name

leucine-rich repeats and IQ motif containing 4
Synonyms

4930558O21Rik

Feature Type

protein coding gene
IDs

MGI:1915557
NCBI Gene: 68307
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr3:30698656-30726580 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 14.27 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

700 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915557	protein coding gene	Chr3:30698636-30726583 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027124	protein coding gene	Chr3:28142279-28169259 (+)
A/J	MGP_AJ_G0027084	protein coding gene	Chr3:27771504-27802325 (+)
AKR/J	MGP_AKRJ_G0027053	protein coding gene	Chr3:28193698-28222302 (+)
BALB/cJ	MGP_BALBcJ_G0027096	protein coding gene	Chr3:27468259-27495995 (+)
C3H/HeJ	MGP_C3HHeJ_G0026838	protein coding gene	Chr3:28223180-28250477 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027542	protein coding gene	Chr3:29644817-29671777 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024903	protein coding gene	Chr3:25685379-25713831 (+)
CAST/EiJ	MGP_CASTEiJ_G0026292	protein coding gene	Chr3:28123607-28150478 (+)
CBA/J	MGP_CBAJ_G0026816	protein coding gene	Chr3:30382145-30412327 (+)
DBA/2J	MGP_DBA2J_G0026950	protein coding gene	Chr3:27332312-27359690 (+)
FVB/NJ	MGP_FVBNJ_G0026918	protein coding gene	Chr3:26775067-26802194 (+)
LP/J	MGP_LPJ_G0027061	protein coding gene	Chr3:28826911-28855090 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026938	protein coding gene	Chr3:32976065-33006051 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027601	protein coding gene	Chr3:27939017-27968292 (+)
PWK/PhJ	MGP_PWKPhJ_G0026025	protein coding gene	Chr3:26830520-26859048 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025837	protein coding gene	Chr3:27458589-27490885 (+)
WSB/EiJ	MGP_WSBEiJ_G0026366	protein coding gene	Chr3:28043814-28071331 (+)

Human Ortholog

LRRIQ4, leucine rich repeats and IQ motif containing 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRRIQ4, leucine rich repeats and IQ motif containing 4
Synonyms

LRRC64
Links

HGNC:34298

NCBI Gene ID: 344657

neXtProt AC: NX_A6NIV6

UniProt: A6NIV6
Chr Location

3q26.2; chr3:169812870-169837773 (+) GRCh38

MGI Vertebrate Homology

Lrriq4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LRRIQ4
Gene Tree

Lrriq4

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References

1 with disease annotations

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Phenotype Summary

7 phenotype references

All Mutations and Alleles

25
Gene trapped

21
Radiation induced

1
Targeted

3
Genomic Mutations

1 involving Lrriq4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available

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All GO Annotations

1
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

7

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lrriq4

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All Sequences

40
RefSeq

8
UniProt

2
CCDS

CCDS38406.1, CCDS71229.1

Ensembl

ENSMUSG00000027703 (Evidence)
NCBI Gene

68307

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027703	Ensembl Gene Model \| MGI Sequence Detail	27925	C57BL/6J	± kb
transcript	ENSMUST00000172350	Ensembl \| MGI Sequence Detail	1797	Not Applicable
polypeptide	ENSMUSP00000127052	Ensembl \| MGI Sequence Detail	596	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000030311 leucine-rich repeat and IQ domain-containing protein 4

(term hierarchy)
InterPro Domains

IPR000048 IQ motif, EF-hand binding site

IPR001611 Leucine-rich repeat

IPR050216 Leucine-rich repeat domain-containing protein

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

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All nucleic 7

cDNA 7

Microarray probesets 2

Summaries

All 23

Diseases 1

Gene Ontology 1

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Lrriq4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr28681	Chr3:30702072-30702083 (+)	3,422 bp
Tssr28682	Chr3:30702107-30702126 (+)	3,461 bp
Tssr28683	Chr3:30702142-30702156 (+)	3,493 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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